Hyperuricemia and maternal outcome in pregnancy induced hypertension: prospective study in a tertiary care center in Mumbai, India
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20231228Keywords:
PIH, IUFD, HELLP, LSCSAbstract
Background: Pregnancy induced hypertension, preeclampsia, eclampsia are serious complications of pregnancy. They are the leading causes of morbidity and mortality in the world and one of the leading causes for perinatal mortality also. It is the systemic disease affecting all vital organs including the fetus. Estimation of biochemical markers can give us the indication of the severity and prediction of the outcome. Serum uric acid is the end product of purine metabolism, amongst others like creatinine, LDH, transaminases.
Methods: It was a type of prospective descriptive study. The present study was conducted in department of obstetrics and gynecology, Tertiary care hospital, Mumbai, Maharashtra, India.
Results: Pregnancy induced hypertension was most common in age group of 20-25 years, most common complication was preterm delivery which accounts for 43% of maternal complications. 60% of the cases with IUFD had serum uric acid level 8-8.9 mg/dl, 3% of the patients had HELLP syndrome.
Conclusions: We found severity of complication associated with raise in serum uric acid levels.
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References
Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol. 2003;102(1):181-92.
James PR, Nelson-Piercy C. Management of hypertension before, during, and after pregnancy. Heart. 2004;90(12):1499-504.
National Institute of Health and Clinical excellence. Hypertension in pregnancy: The management of hypertensive disorders during pregnancy. CG no. 107. London, UK: National Institute of Health and Clinical excellence; 2010.
Hellaman LM, Pritchard J. Williams obstetrics. 25th edition. McGraw Hill Medical; 2018.
James PR, Nelson-Piercy C. Management of hypertension before, during, and after pregnancy. Heart. 2004;90(12):1499-504.
Khan KS, Wojdyla D, Say L, Gülmezoglu AM, Van Look PF. WHO analysis of causes of maternal death: a systematic review. Lancet. 2006;367(9516):1066-74.
Cunningham FG, Lenovo K, Bloom S, Spong C, Dashe J, Hoffman B, et al. Hypertensive disorders. In: Williams Obstetrics. 25th edn. McGraw Hill Medicals; 2018:710-711.
Bangal VB, Giri PA, Mahajan AS. Maternal and foetal outcome in pregnancy induced hypertension: a study from rural tertiary care teaching hospital in India. Int J Biomed Res. 2011;2(12):595‐9.
Khosravi S, Dabiran S, Lotfi M, Asnavandy M. Study of the prevalence of hypertension and complications of hypertensive disorders in pregnancy. Open J Prevent Med. 2014;4:860-7.
Jayaraman L, Khichi SK, Singh A, Goel S, Karkala J, Goyal P, et al. Pattern of feto-maternal outcome and complications in pregnancy induced hypertension from a tertiary level health care teaching institution of Tamil Nadu, India. Int J Res Med Sci. 2016;4:1402-6.
Lim KH, Friedman SA, Ecker JL, Lu K, Kilpatrick SJ. The clinical utility of serum uric acid measurements in hypertensive diseases of pregnancy. Am J Obstet Gynecol. 1998;178:67-71.
Krishna TS, Krishnamma M, Rajeswari DR, Rao V, Naidu JN. Alterations of serum uric acid concetrations in preeclampsia. Int J Appl Bio Pharm Tech. 2015;6(2):165-7.
Thanna RC, Choudhary R, Pathak S, Vamne A, Nigoskaret S. Level of serum acid in preeclampsia. Int J Clin Biochem. 2015;2(2):120-2.
Yalamati P, Bhongir AV, Betha K, Verma R, Dandge S. Relationship of serum uric acid, serum creatinine and serum cystatin C with maternal and fetal outcomes in rural Indian pregnant women. Int J Reprod Contracept Obstet Gynecol. 2015;4(5):1505-10.
Hawkins TL, Roberts LM, Brown MA. Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy: a retrospective cohort study. BJOG. 2012;119(4):484-92.