Study of histopathological findings of endometrial biopsy in women with abnormal uterine bleeding
Keywords:Abnormal uterine bleeding, Biopsy, Endometrium
Background: Abnormal uterine bleeding is one of the most common problems presenting in OPD to the gynecologist regardless of the age of the women. The main aim was to study the frequency of different histopathological findings of endometrial sample in patients with abnormal uterine bleeding.
Methods: This study was conducted on 82 patients from December 2021 to November 2022 in the department of obstetrics and gynecology. Patients with AUB due to gestational cause like missed abortion, incomplete abortion, retained products of conception and with uterine fibroid were excluded from study.
Results: Abnormal uterine bleeding (AUB) presented mostly in the 41-50 years of age. The commonest histopathological pattern in abnormal uterine bleeding was normal physiological changes of menstrual cycles secretory phase (29%). Endometrial hyperplasia was the most common endometrial pathology observed in 11% patients.
Conclusions: Endometrial evaluation in abnormal uterine bleeding helps in early detection of pre-neoplastic conditions and malignancy to provide early treatment and avoid further complications.
Al-Neaimy WM, Ahmed MT, Al-Jawadi SI. Histopathological Interpretation of Abnormal uterine bleeding after the age of 40 year. Iraqi Postgrad Med J. 2010;9(3):274-82.
Munro GM, Critchley ODH, Fraser SI. The FIGO systems for nomenclature and classification of causes of abnormal uterine bleeding in the reproductive years: who needs them? AJOG. 2012;207(4):259-65.
Management of acute abnormal uterine bleeding in nonpregnant reproductive-aged women. Committee Opinion No. 557. American College of Obstetricians and Gynecologists. Obstet Gynecol. 2013;121:891-6.
Mishra D, Sultan S. FIGO’s PALM-COEIN classification of abnormal uterine bleeding: a clinico-histopathological correlation in Indian setting. J Obstet Gynaecol India. 2017;67:119-25.
Blaustein A. Pathology of the female genital tract. New York: Springer-Verlag; 1994;2:279-31.
Doraiswami S, Johnson T, Rao S, Rajkumar A, Vijayaraghavan J, Panicker VK. Study of endometrial pathology in abnormal uterine bleeding. J Obstet Gynaecol India. 2011;61:426-30.
Sharma R, Mishra P, Kumar N, Srivastava P. Histomorphological spectrum of endometrial lesion in women presenting with abnormal uterine bleeding: a 3-year study at a tertiary care center. Trop J Pathol Microbiol. 2018;4:525-31.
Desai K, Patole K, Kathaley M. Endometrial evaluation by histopathology in abnormal uterine bleeding in perimenopausal and postmenopausal patients. MVP J Med Sci. 2014:75-9.
Jairajpuri ZS, Rana S, Jetley S. Atypical uterine bleeding- Histopathological audit of endometrium- a study of 638 cases. Al Ameen J Med Sci. 2013;6(1):21-8.
Sajitha K, Padma SK, Shettty KJ, Kishan Prasad HL, Permi HS, Hegde P. Study of histopathological patterns of endometrium in abnormal uterine bleeding. CHRISMED J Health Res. 2014;1:76-81.
Mukhopadhyay I, Rao PS, Nataraj S, Biswas M. An analysis of endometrial bleeding patterns in perimenopausal women. Int J Reprod Contracept Obstet Gynecol. 2017;6:2776-83.
Cornitescu FI, Tănase F, Simionescu C, Iliescu D. Clinical, histopathological and therapeutic considerations in non-neoplastic abnormal uterine bleeding in menopause transition. Rom J Morphol Embryol. 2011;52:759-65.
Devi J, Aziz N. Study of histopathological pattern of endometrium in abnormal uterine bleeding in the age group 40-60 years- a study of 500 cases. Int J Med Sci Clin Invent. 2014;1(10):579-85.