The evaluation between vitamin D level and pelvic organ prolapse in post-menopausal women

Zhuma Rani Paul; Nurun Nahar Khanam; Shyamal Chandra Barai; Mst. Nargis Parvin; Plabony Talukder; Masrura Siddiqua; Nurun Nahar; Nigar Sultana; Nasima Rahman; Georgia Haque Dona; Samanta Jahan; Homyera Koly

doi:10.18203/2320-1770.ijrcog20231520

Authors

Zhuma Rani Paul Department of Obstetrics and Gynaecology, 250 Beded General Hospital, Gopalganj, Bangladesh
Nurun Nahar Khanam Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Shyamal Chandra Barai Department of Surgery, 250 Beded General Hospital, Gopalganj, Bangladesh
Mst. Nargis Parvin Department of Immunology, National Institute of Kidney Diseases & Urology, Dhaka, Bangladesh
Plabony Talukder Department of Surgery, Munshiganj Sadar Hospital, Munshiganj, Bangladesh
Masrura Siddiqua Junior Consultant, Sonargoan Upazila Health Complex, Narayanganj, Bangladesh
Nurun Nahar Junior Consultant (Gynae), Kamrangirchar 31 Bed Hospital, Dhaka, Bangladesh
Nigar Sultana Registar (Gynae), Dhaka Medical College Hospital, Dhaka, Bangladesh
Nasima Rahman CL SPL Obst & Gynae, Combined Military Hospital, Dhaka, Bangladesh
Georgia Haque Dona Medical officer, Dhaka Medical College Hospital, Dhaka, Bangladesh
Samanta Jahan RMO, Mamms Institute of Fistula and Womens Health, Dhaka, Bangladesh
Homyera Koly MBBS. MS (Obs and Gynae), Indoor Medical Officer, Sher-E-Bangla Medical College, Barisal, Bangladesh

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20231520

Keywords:

Vitamin D, Skeletal integrity, Pelvic organ prolapse, Postmenopausal women

Abstract

Background: Vitamin D is important for skeletal integrity and optimal muscle function. The high incidence and prevalence of vitamin D deficiency and pelvic organ prolapse have been found in postmenopausal women, raising the question of whether the entities are related. The aim of the study was to evaluation between vitamin D level and pelvic organ prolapse in post-menopausal women.

Methods: This case control study has been designed and conducted in the Department of Obstetrics and Gynecology, BSMMU to investigate the level of vitamin D in patients with and without pelvic organ prolapse to explore the association of vitamin D with pelvic organ prolapse. After taking informed written consent the serum vitamin D level of all participants was measured by CMIA technology with flexible assay protocols at Biochemistry and Molecular Biology department of the same institute. Statistical analysis of the results was obtained by using window-based computer software devised with Statistical Packages for Social Sciences (SPSS-24).

Results: The study population was divided into two groups, a case group (n=74) consisting of patients with pelvic organ prolapse and a control group (n=74) comprising of women without pelvic organ prolapse. A total 148 participants of 52 years or older attending the out or inpatient department were enrolled in the study. Mean±SD level of Vitamin D in the case group was 13.96±5.18 ng/ml and in the control, group was 21.08±5.77 ng/ml respectively. The difference was statistically significant (p<0.05). Moreover, the vitamin D levels were inversely proportionate with the severity of pelvic organ prolapse.

Conclusions: Vitamin D deficiency may be an important systemic factor associated with pelvic organ prolapse. Measuring vitamin D levels in postmenopausal women and replenishing deficiencies may also be important for the pelvic floor.

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