Successful delivery in a case of sickle cell disease with bilateral avascular necrosis: a case report


  • Susmita Mukherjee Department of Obstetrics and Gynecology, Susmita Mukherjee Fertility and Laparoscopy Centre, Indore, Madhya Pradesh, India
  • Amit Bhalla Department of Medical Affairs, Uniza Healthcare LLP, Ahmedabad, Gujarat, India



Sickle cell disease, Bilateral avascular necrosis, Hydroxyurea, Pregnancy in sickle cell disease


Sickle cell disease is an inherited hemoglobinopathy. The patients with sickle cell disease had a small life years, before the advancement of medical science and development of newer drugs. These have improved the life expectancy among the sickle cell disease patients. Females are reaching reproductive age and are expectant of becoming mothers. But pregnancy in a sickle cell disease carries major fetal and maternal complications. Managing the pregnancy from conception to delivery is a difficult task and needs a team effort. Here we presented a case report of a female who got pregnant without any planning and was already on hydroxyurea. On top of that she was not willing to get her pregnancy terminated.


Sorrentino F, Maffei L, Caprari P, Cassetta R, Dell'Anna D, Materazzi S, et al. Pregnancy in thalassemia and sickle cell disease: the experience of an italian thalassemia center. Front Mol Biosci. 2020;7:16.

Chakravarti A, Li CC, Buetow KH. Estimation of the marker gene frequency and linkage disequilibrium from conditional marker data. Am J Hum Genet. 1984;36(1):177-86.

Davies SC, Brozovi M. The presentation, management and prophylaxis of sickle cell disease. Blood Rev. 1989;3(1):29-44.

John Hopkin’s Medicine. Fact sheet: Sickle cell disease. Available at: Accessed on 20 May 2023.

Naik RP, Lanzkron S. Baby on board: what you need to know about pregnancy in the hemoglobinopathies. Am Soc Hematol. 2012;2012:208-14.

Villers MS, Jamison MG, De Castro LM, James AH. Morbidity associated with sickle cell disease in pregnancy. Am J Obstet Gynecol. 2008;199(2):125.

El-Shafei AM, Sandhu AK, Dhaliwal JK. Maternal mortality in Bahrain with special reference to sickle cell disease. Aust N Z J Obstet Gynaecol. 1988;28(1):41-4.

Howard RJ, Tuck SM, Pearson TC. Pregnancy in sickle cell disease in the UK: results of a multicentre survey of the effect of prophylactic blood transfusion on maternal and fetal outcome. Brit J Obstetr Gynaecol. 1995;102(12):947-51.

Elenga N, Adeline A, Balcaen J, Vaz T, Calvez M, Terraz A, et al. Pregnancy in sickle cell disease is a very high-risk situation: an observational study. Obstet Gynecol Int. 2016;2016:9069054.






Case Reports