Role of carboprost in prevention of postpartum hemorrhage

Akanksha Lamba, Godawari Joshi, Madhulika Gupta


Background: Postpartum hemorrhage (PPH) is one of the most common causes of maternal death throughout the world. Pregnancy and childbirth involves significant health risks, even to women with no preexisting health problem. The objective of this study was to analyze the role of carboprost in prevention of PPH.

Methods: This prospective observational study was conducted in the department of obstetrics and gynaecology of Dr. Sushila Tiwari Memorial Hospital, Haldwani, Uttarakhand, India. A total number of 100 cases delivering in the labour room that fulfilled the selection criteria were included. Carboprost 250 microgram (1 ml) was administered intramuscularly to each of the case just after the delivery of the anterior shoulder of baby. Duration of third stage, amount of blood loss, incidence of PPH and side effect profile was studied.

Results: Carboprost reduces the duration and amount of blood loss in the third stage of labour but is associated with a number of unpleasant side effects.

Conclusions: Active management of third stage of labour is recommended in all cases. Carboprost is highly efficacious in reducing the incidence of PPH.


Carboprost, PPH, BRASSE-V-Drape

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Maternal Mortality. Available at URL: Accessed on 01 June, 2016.

Cunningham FG, Gant NF, Leveno KJ (eds). Obstetrical haemorrhage. Williams Obstetrics 23rd edn. USA, McGraw Hill. 2009:757-803.

Hofmeyr GJ, Gulmezoglu AM. New development in the management of postpartum hemorrhage. In: Bonner J. Re-cent Advances in Obstetrics and Gynaecology. 21st edn. London. Churchill Livingstone. 2000:56-66.

Katzung BG. The ergot alkaloids. Basic and clinical pharmacology, Katzung, 6th Edn. USA, Aplleton and Hange; 1995:251-275.

Singh N, Singh U. Methylergometrine and carboprost tromethamine prophy-laxis for postpartum haemorrhage. J Obstet Gynecol India. 2005;55(4):325-8.

Bhide P, Bhide S, Daftary S. Management of third stage of labour. J Obstet Gyne-aecol Ind. 1994;43:734-7.

Yuen PH, Chan NST, Yim SF, Chang AMZ. A randomized double blind comparison of syntometrine and syntocinon in the management of the third, stage of labour. Br J Obstet Gynaecol. 1995;102:377-80.

Chua S, Chew SL, Yeoh CL, Roy AC, Ho LM, Selamat N, et al. A randomized controlled study of prostaglandin 15-methyl F2 alpha compared with syntometrine for prophylactic use in the third stage of labour. Aust N Z J Obstet Gynaecol. 1995;35(4):413-6.

Reddy R, Shenoy JS. Active management of third stage of labour: a comparative study in high risk patients for atonic PPH. J Obstet Gynecol India. 2001;51:44-7.

Bhattacharya P, Devi PK, Jain S. Prophylactic use of 15 (S) 15 methyl PGE2α by intramuscular route for control of postpartum bleeding: a comparative trial with methylergometrine. Acta Obstet Gynecol Scand Suppl. 1988;145:13-5.

Anjaneyulu R, Devi PK, Jain S. Prophylactic use of 15 (5) methyl PGF2α by IM route: a controlled clinical trial. Acta Obstet Gynecol Scand Suppl. 1988;145:9-11.

Purushottam J, Roopa P. Prophylactic intramuscular PGF2α versus intra-venous methyl ergometrine for prevention of atonic PPH in high risk women. J Obstet Gynecol India. 2008;58(5):417-20.

Lamont RF, Morgan DJ, Logue M, Gordon H. A prospective randomised trial to compare the efficacy and safety of hemabate and syntometrine for the prevention of primary postpartum haemorrhage. Prostaglandins Other Lipid Mediat. 2001;66(3):203-10.