Estimation of maternal serum albumin at term to determine its correlation with birth weight of babies


  • Syma Akter Araihazar Upazilla Health Complex, Narayangonj, Bangladesh
  • Erina Tabassum Department of Obstetrics and Gynecology, Keranigonj Upazilla Health Complex, Dhaka, Bangladesh
  • Sharmin Akter Luna Department of Paediatrics, Evercare Hospital, Dhaka, Bangladesh
  • Salma Khatun Department of Obstetrics and Gynecology, Colonel Maleque Medical College Hospital, Manikganj, Bangladesh
  • Mitra Biswas Department of Obstetrics and Gynecology, Proactive Medical College and Hospital, Narayangonj, Bangladesh
  • Beauty Begum Department of Obstetrics and Gynecology, Nachole Upazilla Health Complex, Chapainawabganj, Bangladesh



Animal protein, Maternal albumin, Low birth weight, Ante-natal care


Background: Serum albumin is a vital laboratory indicator of nutrition status. Fetal weight depends upon the nutritional status of mothers. Indeed, the serum albumin status at term may help to assume the fetal weight. We do have not enough research-based data regarding this issue. The aim of this study was to estimate maternal serum albumin at term and to observe its correlation with the birth weight of babies.

Methods: This cross-sectional analytical study was done at department of gynaecology and obstetrics, Sir Salimullah medical college and Mitford hospital, Dhaka, Bangladesh from July 2019 to June 2020. A total of 96 mother-baby pairs were selected using purposive sampling method. Women with single full-term pregnancy based on fundal height on Naegele’s rule irrespective of any mode of delivery was included in this study. Mothers with normal albumin levels (3.6-5.2 gm/dl) were defined as group A and mothers with low albumin levels (<3.6 gm/dl) in group B. Statistical analyses of the results were obtained by using window-based computer software devised with SPSS-22.

Results: In analyzing the maternal serum albumin level, we observed that majority of the participants were with normal albumin levels which were 81% and the rest 19% of patients were low albumin levels. In this study, it was observed that more than half (56.4%) of babies were male in group A and 9 (50.0%) in group B. The majority (94.9%) of babies’ birth weights were ≥2.5 kg in group A and 4 (22.0%) in group B. The difference of birth weight was statistically significant (p<0.05) between the two groups. Maternal serum albumin was significantly associated with birth weight of babies in multivariate analysis. But negatively correlated with newborn birth weight which is statistically significant.   

Conclusions: Maternal albumin was observed to be directly proportional to the birth weight of babies.


World Health Organization. Global Nutrition Targets 2025: Low birth weight policy brief (No. WHO/NMH/NHD/14.5). World Health Organization. 2014. Available at: Accessed on 3 March 2023.

World Health Organization. UNICEF-WHO low birth weight estimates: levels and trends 2000-2015 (No. WHO/NMH/NHD/19.21). World Health Organization. 2019. Available at: https://www.unicef. org/reports/UNICEF-WHO-low-birthweight-estimates-2019. Accessed on 3 March 2023.

Ghojazadeh M, Velayati A, Mallah F, Azami-Aghdash S, Mirnia K, Piri R et al. Contributing death factors in very low-birth-weight infants by path method analysis. Nig Med J. 2014;55(5):389.

De Bernabe JV, Soriano T, Albaladejo R, Juarranz M, Calle ME, Martı́nez D et al. Risk factors for low birth weight: a review. Eur J Obstetr Gynecol Reproduct Biol. 2004;116(1):3-15.

Girma S, Fikadu T, Agdew E, Haftu D, Gedamu G, Dewana Z et al. Factors associated with low birthweight among newborns delivered at public health facilities of Nekemte town, West Ethiopia: a case control study. BMC Pregnancy Childbirth. 2019;19(1):220.

Begum P, Hassan MK, Saha AK, Akter T, Afrin M. Risk Factors of Low Birth Weight Baby: A Review. Faridpur Med College J. 2017;12(1):40-46.

Swarnalatha N, Bhuvaneswari P. An epidemiological study of low birth weight in a tertiary care hospital, Tirupati, Andhra Pradesh. Int J Curr Res Rev. 2023;5(16):54.

Lynch J, Kaplan G. Socio-economic position. In: Social epidemiology. Berkman LF, Kawachi I (eds). Oxford University Press. 2000;13-35.

Stephenson T, Symonds ME. Maternal nutrition as a determinant of birth weight. Arch Dis Child Fetal Neonatal. 2002;86:4-6.

Krishna K, Moniqa A, Wahid A. Umblical cord blood nutrients among low birth weight and normal birth weight babies in primary health care set up in Lucknow India. General Biological Scientific Opinion. 2013;1(1):300-3.

Michael E. Dietary protein, serum albumin and health. 2007. Available at: Accessed on 12 March, 2023.

Mishra V, Dai X, Smith KR, Mika L. Maternal exposure to biomass smoke and reduced birth weight in Zimbabwe. Ann Epidemiol. 2004;14(10):740-7.

Morris I, McCallion N, El-Khuffash A, Molloy EJ. Serum albumin and mortality in very low birth weight infants. Arch Dis Child Feta Neonatal Ed. 2008;93(4):F310-12.

Chaudhry, Rasheed E, Chaudhry ZR, Chaudhry SR. Correlation of Maternal Albumin Levels with Neonatal Birth Weight. J Islamic Int Med College. 2017;12(2):97-100.

World Medical Association. World Medical Association Declaration of Helsinki. Ethical principles for medical research involving human subjects. Bulletin of the World Health Organization. 2001;79(‎4):373-4. World Health Organization. Available at: 10665/268312. Accessed on 12 March, 2023.

Paul V, Von dem Bussche A. Enforcement and fines under the GDPR. The EU General Data Protection Regulation (GDPR). Springer, Cham. 2017;201-17.

Yang C, Liu Z, Tian M, Xu P, Li B, Yang Q, Yang Y. Relationship between serum albumin levels and infections in newborn late preterm infants. Med Sci Monitor. 2016;22:92.

Khan JR, Islam MM, Awan N, Muurlink O. Analysis of low birth weight and its co-variants in Bangladesh based on a sub-sample from nationally representative survey. BMC Pediatr. 2018;18(1):100.

Shah PS. Knowledge Synthesis Group on Determinants of LBW/PT births. Parity and low birth weight and preterm birth: a systematic review and meta‐analyses. Acta Obstetricia et Gynecolog Scand. 2010;89(7):862-75.

Ahmadu BU, Ayodele AAE, Ngadda H, Jungudu U, Mustapha KS. Correlation of maternal albumin and birth weight of babies in a Nigerian Teaching Hospital. Int J Public Health Epidemiol. 2012;1:10-13.

Baba U, Adebayo A, Haruna N, Usman J, Kyari S. Correlation of maternal albumin and birth weight of babies in a Nigerian Teaching Hospital. Int J Publ Health Epidemiol. 2012;1:10-13.

Carlos A, Marilia B. Low birth weight: causes and consequences. Diabetol Metabol Syndrome. 2013;5(1):49-50.

Hamidu JL, Salami HA, Ekanem AU, Hamman L. Prevalence of protein-energy malnutrition in Maiduguri, Nigeria. Afr J Biomed Res. 2003;6(3):123-7.






Original Research Articles