A comparative study of serum lipid profile in preeclampsia and normotensive pregnancy in third trimester and their fetomaternal outcome

Pooja Kumari; Madhubala Chouhan; Balveer Jakhar; Garima Sharma

doi:10.18203/2320-1770.ijrcog20231790

Authors

Pooja Kumari Department of Obstetrics and Gynecology, RNT Medical College, Udaipur, Rajasthan, India
Madhubala Chouhan Department of Obstetrics and Gynecology, RNT Medical College, Udaipur, Rajasthan, India
Balveer Jakhar Department of Obstetrics and Gynecology, RNT Medical College, Udaipur, Rajasthan, India
Garima Sharma Department of Obstetrics and Gynecology, RNT Medical College, Udaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20231790

Keywords:

HDL, LDL, Total cholesterol

Abstract

Background: Preeclampsia is a common medical complication in pregnancy in developing countries. It is one of the most common causes that lead to maternal and fetal morbidity and mortality. Incidence of preeclampsia in world is 3-5%.¹ In India preeclampsia complicates 5-15% of pregnancies. As a result of these changes serial alteration in lipid profile, mainly increase in serum triglycerides, cholesterol occurs in pregnant women.

Methods: After IEC clearance and taking informed written consent from the patients, present study was conducted at the Department of Obstetrics and Gynaecology in PDZH, RNT Medical College, Udaipur from December 2020 to June 2022.

Results: Study result based on 100 pregnant women with pre-eclampsia (BP >140/90 mm of Hg) as cases and 100 normotensive pregnant women (BP <140/90 mm of Hg) as controls. Cases had significantly higher total cholesterol (219.21±63.13 vs. 176.24±31.33, P<.0001), significantly higher triglycerides (mg/dL) (208.35±79.32 vs. 166.41±29.6, P<.0001), significantly higher LDL (mg/dL) (133.7±39.81 vs. 103.96±18.38, P<.0001), and significantly lower HDL (mg/dL) (43.29±7.09 vs. 50.18±8.15, P<.0001) in comparison to control.

Conclusions: Women with pre-eclampsia had significantly higher serum Cholesterol, LDL, TG and significantly lower HDL in comparison to healthy pregnant women. There was a significant increase in the serum Cholesterol, LDL, TG in patients from mild to severe pre-eclampsia.

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References

Sengodan SS, Sreeprathi N. Prevalence of hypertensive disorders of pregnancy and its maternal outcome in a tertiary care hospital, Salem, Tamil Nadu, India. Int J Reprod Contracept Obstet Gynecol. 2020;9(1):236-9.

Say L, Chou D, Gemmill A, Moller AB, Daniels J, Temmerman M, et al. Global causes of maternal death: a WHO systematic analysis. Lancet Glob Health. 2014; (6):323-33.

Butwick AJ, Druzin ML, Shaw GM, Guo N. Evaluation of US state–level variation in hypertensive disorders of pregnancy. JAMA Netw Open. 2020;3(10):e2018741.

Armaly Z, Jadaon JE, Jabbour A, Abassi ZA. Preeclampsia: Novel mechanisms and potential therapeutic approaches. Front Physiol. 2018;9:973.

Uzan J, Carbonnel M, Piconne O, Asmar R, Ayoubi JM. Pre-eclampsia: pathophysiology, diagnosis, and management. Vasc Health Risk Manag. 2011;7:467-74.

Berry C, Atta MG. Hypertensive disorders in pregnancy. World J Nephrol. 2016;5(5):418-28.

Umesawa M, Kobashi G. Epidemiology of hypertensive disorders in pregnancy: prevalence, risk factors, predictors and prognosis. Hypert Res. 2017;40:213-20.

Bamfo JE, Kametas NA, Chambers JB, Nicolaides KH. Maternal cardiac function in normotensive and pre-eclamptic intrauterine growth restriction. Ultrasound Obstet Gynecol. 2008;32(5):682-6.

Singh U, Solanki V, Mehrotra S, Sharma R. An evaluation of applicability of salivary uric acid measurement in preeclampsia and normal pregnancy and its correlation with serum uric acid. J Obstet Gynaecol India. 2019;69(1):62-8.

Brown MA, Magee LA, Kenny LC, Karumanchi SA, McCarthy FP, Saito S, et al. Hypertensive Disorders of Pregnancy: ISSHP Classification, Diagnosis, and Management. Recommendations for International Practice. Hypert. 2018;72:24-43.

Timalsina S, Gyawali P, Bhattarai A. Comparison of lipid profile parameters and oxidized low-density lipoprotein between normal and preeclamptic pregnancies in a tertiary care hospital in Nepal. Int J Womens Health. 2016;8:627-31.

Ahmed AAM, El Omda FAA, Mousa MSM. Maternal lipid profile as a risk factor for preeclampsia. The Egypt J Hosp Med. 2018;71(6):3434–8.

Saha D, Roy P, Pal R, Ganguli TK, Maity S, Rakshit BM, et al. Serum lipid profile-how it alters in normotensive and hypertensive pregnant women. J Evol Med Dental Sci. 2013;2(31):5895–903.

Vani I, Gayathri A, Nagamani T. Lipid profile parameters in normal and preeclampsia complicating pregnancies - A prospective observational study. Am J Sci Med Res. 2015;1(1):61-6.

Deshpande H, Madkar C, Vishnoi P. Study of serum lipid profile in pregnancy induced hypertension. Indian J Appl Res. 2016;6:546-8.

Anuradha R, Durga T. Estimation of lipid profile among preeclampsia woman by comparing with normal pregnancy. Int J Contemp Med Res. 2016;3(7):1958-61.

Yadav S, Agrawal M, Hariharan C, Dewani D, Vadera K, Krishna N. A comparative study of serum lipid profile of women with preeclampsia and normotensive pregnancy. J Datta Meghe Inst Med Sci Univ. 2018;13(2):83-6.

Attah RA, Monsur AT, Galadanchi H, Omole OA. A comparative study of serum lipid levels in pre-eclamptic and normotensive pregnant women in a tertiary hospital, Northwest Nigeria. Biomed J Sci Tech Res. 2018;3(1):3003-11.

Nidhi, Kaur S, Fayyaz S. Study of serum lipid profile in pregnancy and its correlation with preeclampsia. Obst Gyn Int J. 2019;10(3):169-74.

Mohammed GK, Ayad WA, El-Gazzar UB, Eid SM. Maternal plasma lipid concentration in third trimester of women with preeclampsia and normotensive pregnancy. IJMA. 2020;2(2):405-11.

Adewara OE, Ogundolire AN, Adeniyi AA, Ghazali SM, Awoyinka SB, Adebara I, et al. Maternal serum lipids in pre-eclamptic and normotensive pregnant women: a case-control study. Open J Obstet Gynecol. 2021;11:1619-28.

Sierra-Laguado J, Garcıa RG, Celedón J, Arenas-Mantilla M, Pradilla LP, Camacho PA, et al. Determination of insulin resistance using the Homeostatic Model Assessment (HOMA) and its relation with the risk of developing pregnancy-induced hypertension. AJH. 2007;20:437-42.

Gavali S, Patil A, Gavali U. Study of fetomaternal outcome in patients with pregnancy induced hypertension at Sangli district. Med Pulse Int J Gynaecol. 2021;20(2):65-9.

Sultana A, Koil LN, Sayeeda S. Clinical study on risk factors and fetomaternal outcome of severe preeclampsia in Bangabandhu Sheikh Mujib Medical University. Chattagram Maa-O-Shishu Hospital Med Coll J. 2018;17(1):23-8.

Ajah LO, Ozonu NC, Ezeonu PO, Lawani LO, Obuna JA, Onwe EO. The feto-maternal outcome of preeclampsia with severe features and eclampsia in Abakaliki, South-East Nigeria. J Clin Diagn Res. 2016;10(9):QC18-QC21.