Association of metabolic syndrome and endometrial pathologies in postmenopausal women


  • Kiran Pandey Department of Obstetrics and Gynecology, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • Sudha Kumari Department of Obstetrics and Gynecology, GSVM Medical College, Kanpur, Uttar Pradesh, India; Kalyan Singh Super Speciality Cancer Institute and Hospital, Lucknow, Uttar Pradesh, India
  • Pavika Lal Department of Obstetrics and Gynaecology, GSVM Medical College, Kanpur, Uttar Pradesh, India.
  • Garima Gupta Department of Obstetrics and Gynecology, GSVM Medical College, Kanpur, Uttar Pradesh, India
  • Ajay Bhagoliwal Kalyan Singh Super Speciality Cancer Institute and Hospital, Lucknow, Uttar Pradesh, India



Menopausal women, Metabolic syndrome, Post-endometrial pathologies


Background: The menopausal state may predispose the women to the development of metabolic syndrome as its prevalence has been reported to increase after the attainment of menopause. The aim of this study was to determine the prevalence of metabolic syndrome and its components in post-menopausal women and to assess the association between metabolic syndrome and endometrial pathologies in post-menopausal women.

Methods: An observational study conducted at gynecology OPD of GSVM Medical College, Kanpur and Total 80 post-menopausal women who had history of at least 1 year cessation of menses.

Results: Endometrial pathology was present in 63.2% of patients with metabolic syndrome and in 38.1% of patients without metabolic syndrome. The association between endometrial pathology and metabolic syndrome was found to be statistically significant (p=0.025). The highest incidence was found for fasting glucose (86.8%) followed by blood pressure (81.5%), high triglycerides (81%), low HDL (60.5%), and waist circumference (23.6%). Waist circumference, triglyceride, HDL, diabetes, waist circumference had postulated to be predictors for endometrial pathology.

Conclusions: Endometrial cancer is a type of metabolic syndrome-related tumor. Elucidating the specific roles and the possible mechanisms of metabolic syndrome in pathogenesis of endometrial cancer is expected to provide a new target for the early prevention and treatment of endometrial cancer.


WHO Technical Report Series 866. Research on the menopause in the 1990s. Available from: Accessed on 2 March 2023.

Burger HG, Dudley EC, Robertson DM, Dennerstein L. Hormonal changes in the menopause transition. Recent Prog Horm Res. 2002;57:257-75.

Petri Nahas EA, Padoani NP, Nahas-Neto J, Orsatti FL, Tardivo AP, Dias R. Metabolic syndrome and its associated risk factors in Brazilian postmenopausal women. Climacteric J Int Menopause Soc. 2009;12(5):431-8.

Kannel WB, Wilson PW. Risk factors that attenuate the female coronary disease advantage. Arch Intern Med. 1995;155:57-61.

Park YW, Zhu S, Palaniappan L, Heshka S, Carnethon MR, Heymsfield SB. The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med. 2003;163:427-36.

Ford ES, Giles WH, Mokdad AH. Increasing prevalence of metabolic syndrome among US adults. Diabetes Care. 2004;27:2444-9.

Zhang Y, Liu Z, Yu X, Zhang X, Lü S, Chen X, et al. The association between metabolic abnormality and endometrial cancer: a large case control study in China. Gynecol Oncol. 2010;117:41-6.

Lindemann K, Vatten LJ, Ellstrom-Engh M, Eskild A. Body mass, diabetes and smoking and endometrial cancer risk: a follow up study. Br J Cancer. 2008;98:1582-5.

Faulds MH, Dahlman-Wright K. Metabolic diseases and cancer risk. Curr Opin Oncol. 2012;24(1):58-61.

Saad MF, Lillioja S, Nyomba BL, Castillo C, Ferraro R, De Gregorio M, et al. Racial differences in the relation between blood pressure and insulin resistance. N Engl J Med. 1991;324:733-9.

Özdemir S, Batmaz G, Ates S, Celik C, Incesu F, Peru C. Relation of metabolic syndrome with endometrial pathologies in patients with abnormal uterine bleeding. J Gynaecol Endocrinol. 2015;31(9):725-9.

Figueiredo Neto JA, Figuerêdo ED, Barbosa JB, Barbosa FD, Costa GR, Nina VJ, et al. Metabolic syndrome and menopause: cross-sectional study in gynecology clinic. Arq Bras Cardiol. 2007;95:339-45.

Sharma S, Aggarwal N, Joshi B, Suri V, Badada S. Prevalence of metabolic syndrome in pre- and post-menopausal women: a prospective study from apex institute of North India. J Midlife Health. 2016;7(4):169-74.

Pandey S, Srinivas M, Agashe S, Joshi J, Galvankar P, Prakasam CP, et al. Menopause and metabolic syndrome: A study of 498 urban women from western India. J Midlife Health. 2010;1(2):63-9.

Gupta R, Sarna M, Thanvi J, Rastogi P, Kaul V, Gupta VP. High prevalence of multiple coronary risk factors in Punjabi Bhatia community: Jaipur Heart Watch-3. Indian Heart J. 2004;56:646-52.

Sawant A, Mankeshwar R, Shah S, Raghavan R, Dhongde G, Raje H, et al. Prevalence of metabolic syndrome in urban India. Cholesterol. 2011;2011:920983.

Afzal S, Bashir MN. Prevalence of metabolic syndrome in pre and postmenopausal diabetics. Biomedica. 2008;24:26-30.

Lindemann K, Vatten LJ, Ellstrøm-Engh M, Eskild A. Serum lipids and endometrial cancer risk: results from the HUNT-II study. Int J Cancer Res. 2009;124:2938-41.

Cust AE, Kaaks R, Friedenreich C, Bonnet F, Laville M, Tjønneland A, et al. Metabolic syndrome, plasma lipid, lipoprotein and glucose levels, and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Endocr-Relat Cancer. 2007;14(3):755-67.

Kaya S, Kaya B, Keskin HL, Kayhan Tetik B, Yavuz FA. Is there any relationship between benign endometrial pathologies and metabolic status? J Obstet Gynaecol. 2019;39(2):176-83.






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