A prospective study of association of inflammatory markers with BMI in women with polycystic ovarian syndrome
Keywords:PCOS, BMI, Corelation, Inflammation, Inflammatory markers
Background: Many studies have demonstrated the association between polycystic ovary syndrome (PCOS) and chronic low-grade inflammation to be of unknown mechanism or an unclear cause; which could either be due to the underlying obesity, insulin resistance, or the polycystic ovary syndrome itself. The aim of our study was to find if there was any correlation between the inflammatory markers and body mass index (BMI) in women with PCOS.
Methods: Our study included 100 women aged between 18-45 years with PCOS and were recruited for the study in the obstetrics and gynecology department, Pacific Medical College and Hospital, Rajasthan from October 2020 to April 2022. The enrolled patients then underwent a series of clinical, ultrasonographic and biochemical investigations.
Results: WBC was positively correlated with BMI (r=0.453, p<0.000) Along with that, we were also able to establish a moderate degree positive correlation between BMI and serum CRP levels (r=0.396, p<0.000). A high degree significant positive correlation was found between ESR count and BMI (r=0.537, p<0.000) and platelet count and BMI (r=0.386, p<0.000).
Conclusions: We discovered that higher WBC concentration, ESR count, platelet count, and serum CRP levels are linked to PCOS. Increase in serum inflammatory cardiovascular risk markers are brought on by PCOS and obesity. In order to determine the relative contributions of various factors, such as insulin resistance, androgen status, and BMI, further studies need to be carried out with a larger sample size as the mechanism for the chronic low-grade inflammation still remains unclear.
Azziz R. PCOS in 2015: new insights into the genetics of polycystic ovary syndrome. Nat Rev Endocrinol. 2016;12:74.
El Hayek S, Bitar L, Hamdar LH, Mirza FG, Daoud G. “Poly cystic ovarian syndrome: an updated overview.” Front Physiol. 2016;7:124.
Kelly CC, Lyall H, Petrie JR, Gould GW, Connell JM, Sattar N. Low grade chronic inflammation in women with polycystic ovarian syndrome. J Clin Endocrinol Metab. 2001;86(6):2453-5.
Orio Jr F, Palomba S, Cascella T, Di Biase S, Manguso F, Tauchmanovà L, et al. The increase of leukocytes as a new putative marker of low-grade chronic inflammation and early cardiovascular risk in polycystic ovary syndrome. J Clin Endocrinol Metab. 2005;90(1):2-5.
Escobar-Morreale HF, Villuendas G, Botella-Carretero JI, Sancho J, San Millan JL. Obesity, and not insulin resistance, is the major determinant of serum inflammatory cardiovascular risk markers in pre-menopausal women. Diabetologia. 2003;46:625-33.
Deswal R. The prevalence of polycystic ovary syndrome: a brief systematic review. J Hum Reprod Sci. 2020;13(4): 261-71.
Papalou O, Livadas S, Karachalios A. White blood cells levels and PCOS: direct and indirect relationship with obesity and insulin resistance, but not with hyperandogenemia. Hormones. 2015;14(1):91-100, 2015.
Herlihy AC, Kelly RE, Hogan JL. Polycystic ovary syndrome and the peripheral blood white cell count. J Obstet Gynaecol. 2011;31(3):242-4.
Tola EN, Yalcin SE, Dugan N. The predictive effect of inflammatory markers and lipid accumulation product index on clinical symptoms associated with polycystic ovary syndrome in nonobese adolescents and younger aged women. Eur J Obstet Gynecol Reprod Biol. 2017;214:168-72.
Gonzalez F, Thusu K, Abdel-Rahman E, Dandona P. Elevated serum levels of tumor necrosis factor α in normal-weight women with polycystic ovary syndrome. Metabolism. 1999;48:437-41.
Xiong YL, Liang XY, Yang X, Li Y, Wei LN. Low-grade chronic inflammation in the peripheral blood and ovaries of women with polycystic ovarian syndrome. Eur J Obstet Gynecol Reprod Biol. 2011;159:148-50.
Tarkun I, Arslan BC, Cantürk Z. Endothelial dysfunction in young women with polycystic ovary syndrome: relationship with insulin resistance and low-grade chronic inflammation. J Clin Endocrinol Metab. 2004;89(11):5592-6.