Comparative study of serum calcium in pre-eclamptic and normotensive pregnant women at Federal Teaching Hospital Katsina
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20232710Keywords:
Normotensive women, Pregnancy, Serum calcium, Pre-eclamptic womenAbstract
Background: Studies have linked calcium to the aetiopathogenesis and prevention of preeclampsia, however, the precise mechanism involved is unclear therefore this study aimed to determine the relation between serum calcium and preeclampsia among normotensive pregnant women.
Methods: The study was a cross-section descriptive design that included 88 pregnant women with singleton fetuses all at gestational ages above 20 weeks. Socio-demographic and obstetric data were obtained using a structured self-administered questionnaire. Urinary protein estimation was detected using the dipstick measurement of clean catch midstream urine specimens and blood samples were collected for serum calcium. Statistical analysis was done using SPSS version 21.
Results: The majority of the participants 20 (45.5%) age range was between 15-44 years and the majority were also primigravida 31 (70.5%). Serum calcium level was significantly low among the study group 1.97±0.49 compared to the control 2.22±0.12. There was a significantly high systolic BP (162.11±18.01) and diastolic (104.88±16.69) among the study group with significant proteinuria.
Conclusions: This finding suggested that serum calcium could be used as a marker for preeclampsia and based on the findings of this study, serial measurements of serum calcium among women who are at risk for pre-eclampsia may be used to predict the onset and severity of preeclampsia.
References
Koley A, Das S, Sarkar S, Char D, Saha TK. Association of serum calcium and uric acid level with hypertensive disorders of pregnancy (preeclampsia and eclampsia) and their correlation with disease severity. IOSR J Dent Med Sci. 2013;9(5):32-5.
Purohit A, Vyas RK, Sharma ML, Soni Y, Verma A, Dadheech G. Alteration in serum calcium level in preeclampsia compared to normal pregnancy. Int J Clin Biochem Res. 2015;2(4):242-5.
Villar J, Betran AP, Gulmezoglu M. Epidemiological basis for the planning of maternal health services. London: WHO/RHR; 2001.
Adewolu OF. Serum sodium, potassium, calcium and magnesium in women with pregnancy-induced hypertension and preeclampsia in Oredo local government, Benin metropolis: A pilot study. Afr J Med Health Sci. 2013;12:1-5.
Ugwuja EI, Famurewa AC, Ikaraoha CI. Comparison of Serum Calcium and Magnesium Between Preeclamptic and Normotensive Pregnant Nigerian Women in Abakaliki, Nigeria. Ann Med Health Sci Res. 2016;6(1):33-7.
Jarjou LM, Prentice A, Sawo Y. Randomized, placebo-controlled, calcium supplementation study in pregnant Gambian women: effects on breast-milk calcium concentrations and infant birth weight, growth, and bone mineral accretion in the first year of life. Am J Clin Nutr. 2006;83(3):657-66.
Beinder E, Calcium supplementation in pregnancy- is it a must? Ther Umsch. 2007;64:243-7.
Punthumapol C, Kittichotpanich B. Serum calcium, magnesium and uric acid in preeclampsia and normal pregnancy. J Med Assoc Thai. 2008;91:968-73.
Cunningham FG. Hypertensive disorder in pregnancy. In: Cunningham FG, Leveno KJ, Bloom SL, Hauth JC, Gilstre PL, Wenstrom KD, eds. Textbook of Williams Obstetrics. 22nd edn. New York: McGraw-Hill; 2005:761-808.
Roberts JM, Cooper DW. Pathogenesis and genetics of pre-eclampsia. Lancet. 2001;357:53-6.
Chaurasia PP, Jadav PA, Jasani JH. Changes in serum calcium and serum magnesium level in preeclampsia vs normal pregnancy. Int J Biomed Adv Res. 2012;3:511-3.
Sejovia B, Veja I, Villarreal E, Licona NA. Hypocalciuria during pregnancy as a risk factor of pre-eclampsia. Gineccol Obstet Mexico. 2004;72:570-4.
Elawad, Terteel, Scott, Georgia, Bone, Jeffrey N. Risk et al. Factors for pre-eclampsia in clinical practice guidelines: Comparison with the evidence. BJOG: An International Journal of Obstetrics and Gynaecology 2022.
Kumru S, Aydin S, Simsek M, Sahin K. Comparison of serum copper, zinc, calcium and magnesium levels in preeclamptic and healthy pregnant women. Biol Tranc Elem Res. 2003;94:105-12.
Duvekot EJ, De Groot C, Bloema-Kamp K, Oei S. Pregnant women with low milk intake have an increased risk of developing pre-eclampsia. Eur J Obstet Gynecol Reprod Biol. 2002;105:11-4.
Ritchie LD, King JC. Dietary calcium and pregnancy induced hypertension. Is there a relation? Am J Clin Nutr. 2000;71:1371.
Agu CT, Okeudo C. A Comparative Study of Serum Calcium Levels between Pre-eclamptic and Normotensive Singleton Pregnancies in Federal Medical Centre, Owerri. J Adv Med Med Res. 2018;27(11):1-8.
Magee L, Helewa M, Montquin J, Dadelszen P. Diagnosis, evaluation and management of the hypertensive disorders of pregnancy. JOGC. 2008;206:17.
Shenqi W, Xulong H, Yu L, Huijuan L, Li W, Yugian B, et al. Serum electrolyte levels in relation to macrovascular complication in Chinese patients with diabetes mellitus. Cardiovasc Diabetol. 2013;12:146.
Ugwuja EI, Famurewa AC, Ikaraoha CI. Comparison of serum calcium and magnesium between preeclamptic and normotensive pregnant Nigerian women in Abakaliki, Nigeria. Ann Med Health Sci Res. 2016;6:33-7.
Owusu Darkwa E, Antwi-Boasiako C, Djagbletey R, Owoo C, Obed S, Sottie D. Serum magnesium and calcium in preeclampsia: a comparative study at the Korle-Bu Teaching Hospital, Ghana. Integr Blood Press Control. 2017;10:9-15
Guhan VN, Jeyakumar M, Prabhakara RK, Daniel M, Sivaa R, Priyadharshini S. Serum calcium and magnesium levels in preeclamptic patients- a case control study. Int J Pharm Sci Rev Res. 2014;26:149-51.
Levine RJ, Hauth JC, Curet LB, Sibai BM, Catalano PM, Morris CD, et al. Trial of calcium to prevent preeclampsia. N Engl J Med. 1997;337:69-76.
Ulasi II, Ijoma CK, Onodugo OD. A community-based study of hypertension and cardio-metabolic syndrome in semi-urban and rural communities in Nigeria. BMC Health Serv Res. 2010;10:71.
Golmohammad S, Amirabi A, Yazdian M, Pashapour N. Evaluation of serum calcium, magnesium, copper, and zinc levels in women with preeclampsia. Iran J Med Sci. 2008;33:231-4.
Ehret GB, Caulfield MJ. Genes for blood pressure: an opportunity to understand hypertension. Eur Heart J. 2013;34:951-61.
Sethi S, Chaudhary A, Sonkhya P, Mital P, Arora A, Kasana VK, et al. A comparative study of serum calcium and magnesium levels in women with pre-eclampsia and normotensive women. Int J Reprod Contracept Obstet Gynecol. 2021;10:2420-6.
