A study on pregnancy outcome following previous spontaneous abortion: a hospital-based prospective observational comparative study
Keywords:IUGR, Preterm labour, Previous spontaneous abortion
Background: Majority of spontaneous pregnancy loss occur in early gestation. Early pregnancy loss causes great physical and psychological distress to couples and creates apprehension in achieving future reproductive success. Previous abortions have a definite impact on the successful outcome of future pregnancies. Hence for such pregnancies careful antenatal care is mandatory. Careful surveillances required in pregnancies preceded by spontaneous abortions, for early detection of possible complications.
Methods: This was a prospective observational comparative study conducted on 184 antenatal women (92 patients with previous spontaneous abortion, no full-term delivery, selected as cases while 92 patients with previous full term normal vaginal delivery with no previous abortion selected as control) attending antenatal OPD at Holy Family Hospital, New Delhi, from October 2020 to May 2022. All women received regular antenatal care and were followed up till delivery for maternal and foetal outcome.
Results: For predicting pregnancy outcome following previous spontaneous abortion showed statistically significant in term of obesity, 56.52% patients were obese in cases while in controls only 48.91%. Duration of marriage, in cases is 2.22 years, where as in controls were 4.24 years with significant result. Interpregnancy interval (months) in cases was 10.58±4.19 whereas in controls it was 32.53±14.41 with significant result. Antenatal complications in term of GDM, hypothyroidism, IUGR more in cases than controls.
Conclusions: We found that prior spontaneous abortion miscarriage is definitely a risk factor for the next pregnancy, making present pregnancy a high-risk pregnancy.
Muzaffar U, Rashid S, Salaam S, Yousuf S. Outcome of pregnancy following previous spontaneous abortion. Indian J Obstet Gynaecol Res. 2020;7(2):207-9.
Bishnoi S, Bishnoi RK, Bhati BS. To find out the incidence of adverse outcomes in pregnancy preceded by spontaneous abortion compared to those preceded by full term live births: a hospital based study. Int J Med Res Prof. 2019;5(3):253-55.
Nehal N, Sawant V. Pregnancy outcome following previous history of spontaneous abortion. Obs Rev J Obstet Gynecol. 2019;5(1):53-8.
Chandna A, Sood A, Mittal R, Soni S. 2015. A study on pregnancy outcome following previous one spontaneous abortion. Int J Reprod Contracept Obstet Gynaecol. 2015:1879-81.
Bakshi K, Rani TU, Kumar PP, Prabhakar GC. Risk of adverse pregnancy outcomes after prior spontaneous abortion. Curr Med Res Pract. 2015;5(6):258-61.
Rama CH., Annapurna K. An obstetric outcome after previous spontaneous abortion. Indian J Appl Res. 2015;5(5).
Bhattacharya S, Lowit A, Bhattacharya S, Raja EA, Lee AJ, Mahmood T, et al. Reproductive outcomes following induced abortion: a national register-based cohort study in Scotland. BMJ Open. 2012;2(4):e000911.
Kashianan M, Akbarian AR, Baradaran H, Shabandoust SH. Pregnancy outcome following previous spontaneous abortion. Gynae Col Obstet Invest. 2006;61:167-70.
Jivraj S, Anstie B, Cheong YC, Fairlie FM, Laird SM, Li TC. Obstetric and neonatal outcome in women with a history of recurrent miscarriage: a cohort study. Hum Reprod. 2001;16(1):102-6.
Olsen BO, Knudsen LB, Christensen K. Low birthweight and preterm birth after short interpregnancy intervals. Am J Obstet Gynecol. 1998;172:259-63.
Agrawal S, Agrawal V, Suhane R. Pregnancy outcome following spontaneous abortions. Int J Reprod Contracept Obstet Gynecol. 2015;4:1891-3.
Thom DH, Nelson LM, Vaughen TL. Spontaneous abortion and subsequent adverse birth outcomes. Am J Obstet Gynecol. 1992;166:111-6.
Alberman E, Roman E, Pharoah PO, Chamberlain G. Birth weight before and after a spontaneous abortion. BJOG. 1980;87(4):275-80.
Brigham SA, Conlon C, Farquharshan RG. A longitudinal study of pregnancy outcome following idiopathic recurrent miscarriage. Hum Reprod. 1999:14(11):2868-71.
Pantelakis Stefanos N. Influence of induced and spontaneous abortions on the outcome of subsequent pregnancies. Am J Obstet Gynecol. 1973;116(6):799-805
Schoenbaum SC, Monson RR, Stubblefield PG, Darney PD, Ryan KJ. Outcome of delivery following an induced or spontaneous abortion. Am J Obstet Gynecol. 1980;136:19-24.
Knudsen UB, Hansen V, Juul S, Secher NJ. Prognosis of anew pregnancy following previous spontaneous abortion. Eur J Obstet Gynecol Reprod Biol. 1991;39:31-6.
Puyenbroek JI, Stolte LA. The relationship between spontaneous and induced abortion and the occurrence of second trimester abortion in subsequent pregnancies. Eur J Obstet Gynecology Reprod Biol. 1983;14(5):299-309.