Comparative study of clinical and endocrinal profile between lean and obese patients of polycystic ovary syndrome


  • Foram R. Kayastha Department of Obstetrics and Gynecology, GMERS Medical College, Junagadh, Gujarat, India
  • Rahul Aparnathi Department of Obstetrics and Gynecology, GMERS Medical College, Junagadh, Gujarat, India
  • Rajankumar Padasala Department of Obstetrics and Gynecology, GMERS Medical College, Junagadh, Gujarat, India
  • Kishankumar Kanani Department of Obstetrics and Gynecology, GMERS Medical College, Junagadh, Gujarat, India



Hyperandrogenism, Infertility, Menstrual irregularities, Obesity, PCOS


Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder having escalation in its prevalence. It is the most frequent cause of oligoanovulatory infertility. This study was conducted to compare the clinical and endocrinal profile of PCOS in lean PCOS (BMI<23 kg/m2) and obese PCOS (BMI>23 kg/m2) women.

Methods: A prospective study was conducted for 6 months in department of obstetrics and gynecology, GMERS Medical college, Junagadh. 100 healthy women who were euthyroid with age range 20-38 years who presented to gynecology OPD and diagnosed to have PCOS according to ESHRE/ASRM criteria were included in the study. BMI (body mass index) was calculated by the formula weight in kg/height in meter square. BMI were calculated were divided into 2 groups. Lean PCOS found in patients with BMI<23 kg/m2 and overweight/obese PCOS found in patients with BMI>23 kg/m2. History of menstrual irregularity, hirsutism, acne, alopecia, infertility, history of weight gain, history of voice change, family history of PCOS, diabetes was taken and hormonal profile was done.

Results: The findings showed a no significant correlation of clinical profile i.e., menstrual irregularities, acne vulgaris, acanthosis nigricans and hirsutism in both groups. The waist-hip ratio was higher obese PCOS women. High levels of serum testosterone were seen in obese women with PCOS, whereas there is no correlation between other hormone like FSH, LH, TSH and LH/FSH in both study groups.

Conclusions: PCOS is a risk factor for endocrinal and metabolic derangements irrespective of the BMI status. More than half of women with PCOS were obese. Increased BMI in PCOS women is associated with increased WHR and raised serum testosterone with no difference in other endocrine parameters.


Ghatnatti V, Patil S, Kour H. Assessment of clinical, biochemical, and hormonal profile of lean versus overweight polycystic ovarian syndrome patients: a cross-sectional study. APIK J Intern Med. 2022;10(1):13-6.

El Hayek S, Bitar L, Hamdar LH, Mirza FG, Daoud G. Poly cystic ovarian syndrome: an updated overview. Front Physiol. 2016;7:124.

Legro RS, Feingold KR, Anawalt B, Boyce A, Chrousos G, de Herder WW, et al. evaluation and treatment of polycystic ovary syndrome. In: Endotext. South Dartmouth (MA):, Inc.; 2000.

Kamrul-Hasan AB, Aalpona FT. Comparison of clinical, metabolic, and hormonal parameters in lean vs. obese women with polycystic ovary syndrome: a single-center study from Bangladesh. Sri Lanka J Diabetes Endocrinol Metab. 2021;11:15-25.

Akshaya S, Bhattacharya R. Comparative study of clinical profile of lean and obese polycystic ovary syndrome women. Int J Reprod Contracept Obstet Gynecol. 2016;5:2530-3.

Pasquali R. Obesity and androgens: facts and perspectives. Fertil Steril. 2006;85:1319-40.

Cattrall FR, Healy DL. Long term metabolic, cardiovascular and neoplastic risks with polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol. 2004;18:803-12

Rotterdam ESHRE/ASRM‐Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long‐term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41-7.

Kumar N, Agarwal H. Early clinical, biochemical and radiological features in obese and non-obese young women with polycystic ovarian syndrome: a comparative study. Horm Metab Res. 2022;54(9):620-4.

Barber TM, Franks S. Obesity and polycystic ovary syndrome. Clin Endocrinol 2021;95(4):531-41.

Makhija N, Tayade S, Toshniwal S, Tilva H. Clinico-metabolic profile in lean versus obese polycystic ovarian syndrome women. Cureus. 2023;15(4):e37809.

Ali EA, Ahmed AL, Satha M, Khateeb AL. The association between serum nesfatin-1 level and BMI in Iraqi patients with polycystic ovary syndrome (PCOS). Health Res Policy Syst. 2021;15:1490-5.

Silfen ME, Denburg MR, Manibo AM, Lobo RA, Jaffe R, Ferin M, et al. Early endocrine, metabolic, and sonographic characteristics of polycystic ovary syndrome (PCOS): comparison between nonobese and obese adolescents. J Clin Endocrinol Metab. 2003;88(10):4682-8.

Gupta P, Agrawal S, Agarwal A, Pandey A, Kumar N, Ali W. Comparison of Endocrine and Metabolic Profile of Obese and Lean PCOS Women with Infertility. Int J Infertil Fet Med. 2022;13(3):125-8.

Saxena P, Prakash A, Nigam A, Mishra A. Polycystic ovary syndrome: Is obesity a sine qua non? A clinical, hormonal, and metabolic assessment in relation to body mass index. Indian J Endocr Metab. 2012;16(6):996.

Liou TH, Yang JH, Hsieh CH, Lee CY, Hsu CS, Hsu MI. Clinical and biochemical presentations of polycystic ovary syndrome among obese and nonobese women. Fertil Steril. 2009;92(6):1960-5.

Mahmoud MI, Habeeb F, Kasim K. Reproductive and biochemical changes in obese and non obese polycystic ovary syndrome women. Alexandria J Med. 2015;51(1):5-9.

Gupta N, Radhakrishnan G, Madhu SV, Radhika AG. Comparison of metabolic and endocrinal parameters in obese and nonobese women of polycystic ovarian syndrome with normal controls. Fertil Sci Res. 2015;2:19-23.

Sachdeva G, Gainder S, Suri V, Sachdeva N, Chopra S. Obese and non-obese polycystic ovarian syndrome: comparison of clinical, metabolic, hormonal parameters, and their differential response to clomiphene. Indian J Endocrinol Metab. 2019;23(2):257-62.

Majumdar A, Singh TA. Comparison of clinical features and health manifestations in lean versus obese Indian women with polycystic ovarian syndrome. J Hum Reprod Sci. 2009;2(1):12-7.






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