The role of foetal assessment by ultrasound at 11-13+6 weeks of gestation
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20232950Keywords:
Congenital anomalies, Foetal assessment, Ultrasound foetal assessment, 11-13 6 weeks foetal assessmentAbstract
Background: The prevalence of congenital anomalies has been increasing over the years, and it is estimated that every year 1 in 33 infants are affected by some sort of congenital anomaly. At 12 weeks of intrauterine gestation, most of the major foetal structures complete their development and also proper delineation of the foetal anatomy is possible by the time of routine NT scan at 11-13+6 weeks.
Methods: This was a prospective study of 110 cases who underwent a first trimester 11-13+6 weeks scan for congenital foetal abnormalities. The eligibility criteria for selection of cases were first trimester pregnancy between the 11-13+6 weeks gestation and CRL between 45 mm and 84 mm.
Results: The study found that the detection rate of foetus abnormalities was 15.4% in mothers over 35 years old. Total 2.7% of the present study population were detected to be high risk for trisomy 21. All the 110 cases in present study were followed up till delivery/ termination. MTP was performed in 8.1% cases with lethal anomalies and in 1 cases of structural anomaly with missed abortion, D and E was done. 91% delivered live and healthy babies. There was no intrauterine foetal death or still born in present study.
Conclusions: Ultrasound at 11-13+6 weeks must be mandatory, not only for the detection of major foetal anomalies but also for diagnosis of multiple pregnancy and abnormal pregnancy like missed abortion, molar pregnancy and ectopic pregnancy.
Metrics
References
Sarkar S, Patra C, Dasgupta MK, Nayek K, Karmakar PR. Prevalence of congenital anomalies in neonates and associated risk factors in a tertiary care hospital in eastern India. J Clin Neonatol. 2013;2(3):131-4.
Vayna AM, Veduta A, Duta S, Panaitescu AM, Stoica S, Buinoiu N, et al. Diagnosis of fetal structural anomalies at 11 to 14 weeks. J Ultrasound Med. 2018;37(8):2063-73.
ACOG. Ultrasonography in pregnancy- practice bulletin. Obstet Gynecol. 2009;113:451-61.
Cargill Y, Morin L, Bly S, Butt K, Denis N, Gagnon R, et al. Content of a complete routine second trimester obstetrical ultrasound examination and report. J Obstet Gynaecol Can. 2009;31:272-80.
Windrim R. Fetal alert network: a need for a population based antenatal network. Am J Obstet Gynecol. 2006;195(6):S219.
Nazer HJ, Cifuentes OL, Aguila RA, Ureta LP, Bello PMP, Correa CF, et al. Maternal age and congenital malformations: a registry of 35 years. 1970-2005. Rev Med Chil. 2007;135(11):1463-9.
Elamaran E, Daniel S, George RAN. A prospective study to evaluate the efficacy of 11-13+6 weeks anatomy scan in detecting fetal structural anomalies compared to traditional 18-22 weeks scan. Int J Reprod Contracept Obstet Gynecol. 2017;6:2431-7.
Den Hollander NS, Wessels MW, Niermeijer MF, Los FJ, Wladimiroff JW. Early fetal anomaly scanning in a population at increased risk of abnormalities. Ultrasound Obstet Gynecol. 2002;19(6):570-4.
Dinç G, Eyüboğlu İ. Distribution of nuchal translucency thickness at 11 to 14 weeks of gestation in a normal Turkish population. Turk J Med Sci. 2021;51(1):90-4.
Luo W, He B, Han D, Yuan L, Chen X, Pang L, et al. A retrospective analysis of different contingent screening models for fetal Down syndrome in Southwestern China. Sci Rep. 2020;10(1):9457.
Zhang H, Gao Y, Jiang F, Fu M, Yuan Y, Guo Y, et al. Non-invasive prenatal testing for trisomies 21, 18 and 13: clinical experience from 146,958 pregnancies. Ultrasound Obstet Gynecol. 2015;45(5):530-8. Erratum in: Ultrasound Obstet Gynecol. 2015;46(1):130.
Chitty LS, Kagan KO, Molina FS, Waters JJ, Nicolaides KH. Fetal nuchal translucency scan and early prenatal diagnosis of chromosomal abnormalities by rapid aneuploidy screening: observational study. BMJ. 2006;332(7539):452-5.