Clinical status of COVID-19 vaccinated pregnant women: an observational study in a tertiary care hospital in Bangladesh

Hasina Akhter; Shamima Yasmin; Kamrun Nahar

doi:10.18203/2320-1770.ijrcog20233296

Authors

Hasina Akhter Department of Obstetrics and Gynaecology, Combined Military Hospital, Mymensingh, Bangladesh
Shamima Yasmin Department of Obstetrics and Gynaecology, Combined Military Hospital, Dhaka, Bangladesh
Kamrun Nahar Department of Obstetrics and Gynaecology, Combined Military Hospital, Ghatail, Tangail, Bangladesh

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20233296

Keywords:

Clinical status, COVID-19, Vaccinated, Pregnant women, SARS-CoV-2

Abstract

Background: Pregnancy is a special but often stressful time. The COVID-19 pandemic exacerbated this stress. Clinical trials have demonstrated the safety of COVID-19 vaccines for pregnant and lactating women, leading to WHO approval. Consequently, the Bangladesh Government has initiated a vaccination campaign for all expectant mothers to protect them from COVID-19. This study aimed to assess the clinical status of COVID-19-vaccinated pregnant women.

Methods: A cross-sectional study was carried out at Department of Obstetrics & Gynaecology in Combined Military Hospital, Dhaka Cantonment, Bangladesh, spanning August to November 2021. The study included 50 pregnant women who had received COVID-19 vaccinations, selected through purposive sampling. Data analysis and dissemination were performed using MS Office tools.

Results: The study found that the average age was 19.2±10.8 years, with 66% falling into the 25-35 age group. About 50% had a normal BMI, while 22% were overweight (BMI: 25.0-29.9 Kg/m²). Hypertension and diabetes were present in 16% and 12% of cases, respectively. Among the 50 pregnant women, 40% were nulliparous, and 60% were multiparous; in most of the cases (54%), multigravidity (1-5) was found. Vaccination distribution was 28% in the 1^st trimester, 54% in the 2^nd, and 18% in the 3^rd trimester.

Conclusions: COVID-19 vaccination rates are notably higher among pregnant women aged 25-35. The frequency of normal BMI among COVID-19-vaccinated pregnant women is satisfactory. Most pregnant women opt for COVID-19 vaccination during their second trimester.

Metrics

Metrics Loading ...

References

Coronavirus disease (COVID-19) Weekly Epidemiological Update and Weekly Operational Update. Available at: https://www. who.int/m/item/ weekly-epidemiological-update-on-covid-19. Accessed on 20 May 2022.

Jamieson DJ, Rasmussen SA. An update on COVID-19 and pregnancy. Am J Obstet Gynecol. 2022;226: 177-86.

Chen H, Guo J, Wang C. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395:809-15.

Falsaperla R, Leone G, Familiari M, Ruggieri M. COVID-19 vaccination in pregnant and lactating women: a systematic review. Expert Rev Vaccines. 2021;20:1619-28.

Bookstein Peretz S, Regev N, Novick L. Short-term outcome of pregnant women vaccinated with BNT162b2 mRNA COVID-19 vaccine. Ultrasound Obstet Gynecol. 2021;58:450-6.

Konar H. Diagnosis of pregnancy. In: Konar H, ed. DC Dutta’s Textbook of Obstetrics. 9th ed. India: Jaypee Brothers; 2018:60.

WHO SAGE Roadmap for prioritizing uses of COVID-19 vaccines in the context of limited supply. Available at: https://www.who.int/publications/i/ item/who-sage-roadmap-for-prioritizing-uses-of-covid-19-vaccines-in-the-context-of-limited-supply. Accessed on 20 May 2022.

Khalil A, Kalafat E, Benlioglu C. SARS-CoV-2 infection in pregnancy: A systemic review and meta-analysis of clinical features and pregnancy outcomes. Clin Med. 2020.

Heath T, le Doare K, Khalil A. Inclusion of pregnant women in COVID-19 vaccine development. Lancet. 2020;20(9):1007-8.

Shook LL, Fallah PN, Silberman JN. COVID-19 vaccination in pregnancy and lactation: current research and gaps in understanding. Front Cell Infect Microbiol. 2021;11:735.

Jorgensen SCJ, Burry L, Tabbara N. Role of maternal COVID-19 vaccination in providing immunological protection to the newborn. Pharmacotherapy. 2022;42: 58-70.

Razzaghi H, Meghani M, Pingali C. COVID-19 Vaccination Coverage Among Pregnant Women During Pregnancy - Eight Integrated Health Care Organizations, United States. Morb Mortal Wkly Rep. 2021;70:895-9.

Agley J, Xiao Y, Thompson EE, Golzarri-Arroyo L. Factors associated with reported likelihood to get vaccinated for COVID-19 in a nationally representative US survey. Public Health. 2021;196:91-4.

Piekos A, Samantha N. Effect of COVID-19 vaccination and booster on maternalfetal outcomes: a retrospective cohort study. Lancet Digit Health. 2023; 5(9):e594-606.

Ruderman RS, Mormol J, Trawick E, Perry MF, Allen EC, Millan D, Miller ES. Association of COVID-19 vaccination during early pregnancy with risk of congenital fetal anomalies. JAMA Pediatr. 2022; 176:717-9.

Bar-On YM, Goldberg Y, Mandel M. Protection of BNT162b2 vaccine booster against COVID-19 in Israel. N Engl J Med. 2021;385:1393-400.

Ferdinands JM, Rao S, Dixon BE. Waning 2-dose and 3-dose effectiveness of mRNA vaccines against COVID-19-associated emergency department and urgent care encounters and hospitalizations among adults during periods of delta and omicron variant predominanc. Morb Mortal Wkly Rep. 2022;71:255-63.