Clinical status of COVID-19 vaccinated pregnant women: an observational study in a tertiary care hospital in Bangladesh


  • Hasina Akhter Department of Obstetrics and Gynaecology, Combined Military Hospital, Mymensingh, Bangladesh
  • Shamima Yasmin Department of Obstetrics and Gynaecology, Combined Military Hospital, Dhaka, Bangladesh
  • Kamrun Nahar Department of Obstetrics and Gynaecology, Combined Military Hospital, Ghatail, Tangail, Bangladesh



Clinical status, COVID-19, Vaccinated, Pregnant women, SARS-CoV-2


Background: Pregnancy is a special but often stressful time. The COVID-19 pandemic exacerbated this stress. Clinical trials have demonstrated the safety of COVID-19 vaccines for pregnant and lactating women, leading to WHO approval. Consequently, the Bangladesh Government has initiated a vaccination campaign for all expectant mothers to protect them from COVID-19. This study aimed to assess the clinical status of COVID-19-vaccinated pregnant women.

Methods: A cross-sectional study was carried out at Department of Obstetrics & Gynaecology in Combined Military Hospital, Dhaka Cantonment, Bangladesh, spanning August to November 2021. The study included 50 pregnant women who had received COVID-19 vaccinations, selected through purposive sampling. Data analysis and dissemination were performed using MS Office tools.

Results: The study found that the average age was 19.2±10.8 years, with 66% falling into the 25-35 age group. About 50% had a normal BMI, while 22% were overweight (BMI: 25.0-29.9 Kg/m2). Hypertension and diabetes were present in 16% and 12% of cases, respectively. Among the 50 pregnant women, 40% were nulliparous, and 60% were multiparous; in most of the cases (54%), multigravidity (1-5) was found. Vaccination distribution was 28% in the 1st trimester, 54% in the 2nd, and 18% in the 3rd trimester.

Conclusions: COVID-19 vaccination rates are notably higher among pregnant women aged 25-35. The frequency of normal BMI among COVID-19-vaccinated pregnant women is satisfactory. Most pregnant women opt for COVID-19 vaccination during their second trimester.


Coronavirus disease (COVID-19) Weekly Epidemiological Update and Weekly Operational Update. Available at: https://www. weekly-epidemiological-update-on-covid-19. Accessed on 20 May 2022.

Jamieson DJ, Rasmussen SA. An update on COVID-19 and pregnancy. Am J Obstet Gynecol. 2022;226: 177-86.

Chen H, Guo J, Wang C. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395:809-15.

Falsaperla R, Leone G, Familiari M, Ruggieri M. COVID-19 vaccination in pregnant and lactating women: a systematic review. Expert Rev Vaccines. 2021;20:1619-28.

Bookstein Peretz S, Regev N, Novick L. Short-term outcome of pregnant women vaccinated with BNT162b2 mRNA COVID-19 vaccine. Ultrasound Obstet Gynecol. 2021;58:450-6.

Konar H. Diagnosis of pregnancy. In: Konar H, ed. DC Dutta’s Textbook of Obstetrics. 9th ed. India: Jaypee Brothers; 2018:60.

WHO SAGE Roadmap for prioritizing uses of COVID-19 vaccines in the context of limited supply. Available at: item/who-sage-roadmap-for-prioritizing-uses-of-covid-19-vaccines-in-the-context-of-limited-supply. Accessed on 20 May 2022.

Khalil A, Kalafat E, Benlioglu C. SARS-CoV-2 infection in pregnancy: A systemic review and meta-analysis of clinical features and pregnancy outcomes. Clin Med. 2020.

Heath T, le Doare K, Khalil A. Inclusion of pregnant women in COVID-19 vaccine development. Lancet. 2020;20(9):1007-8.

Shook LL, Fallah PN, Silberman JN. COVID-19 vaccination in pregnancy and lactation: current research and gaps in understanding. Front Cell Infect Microbiol. 2021;11:735.

Jorgensen SCJ, Burry L, Tabbara N. Role of maternal COVID-19 vaccination in providing immunological protection to the newborn. Pharmacotherapy. 2022;42: 58-70.

Razzaghi H, Meghani M, Pingali C. COVID-19 Vaccination Coverage Among Pregnant Women During Pregnancy - Eight Integrated Health Care Organizations, United States. Morb Mortal Wkly Rep. 2021;70:895-9.

Agley J, Xiao Y, Thompson EE, Golzarri-Arroyo L. Factors associated with reported likelihood to get vaccinated for COVID-19 in a nationally representative US survey. Public Health. 2021;196:91-4.

Piekos A, Samantha N. Effect of COVID-19 vaccination and booster on maternalfetal outcomes: a retrospective cohort study. Lancet Digit Health. 2023; 5(9):e594-606.

Ruderman RS, Mormol J, Trawick E, Perry MF, Allen EC, Millan D, Miller ES. Association of COVID-19 vaccination during early pregnancy with risk of congenital fetal anomalies. JAMA Pediatr. 2022; 176:717-9.

Bar-On YM, Goldberg Y, Mandel M. Protection of BNT162b2 vaccine booster against COVID-19 in Israel. N Engl J Med. 2021;385:1393-400.

Ferdinands JM, Rao S, Dixon BE. Waning 2-dose and 3-dose effectiveness of mRNA vaccines against COVID-19-associated emergency department and urgent care encounters and hospitalizations among adults during periods of delta and omicron variant predominanc. Morb Mortal Wkly Rep. 2022;71:255-63.






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