Assessment of maternal lipid profile in early pregnancy and its correlation with pregnancy outcome
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20234083Keywords:
Lipoprotein, Lipid physiology, PregnancyAbstract
Background: Lipoprotein lipid physiology in pregnancy has important implications for the developing fetus as well as the mother. Elevated maternal triglycerides levels measured during early pregnancy have been associated with adverse pregnancy outcomes affecting both maternal and fetal health.
Methods: This was a prospective observational study conducted in the Department of Obstetrics and Gynecology, GSVM Medical College Kanpur between January 2020 to October 2021. A total of 146 antenatal women were enrolled in this study, out of which 26 women were lost to follow-up. Lipid profile was done for each subject and was later accessed.
Results: Total cholesterol were deranged in patients 30%, serum TG in 40.83%, LDL in 28.33%, HDL in 35.83%. Out of total of 120 patients, 18 (15%) patients had HDP, 6 (5%) had GDM, 13 (10.83%) had a preterm delivery, 14 (11.66%) had FGR 9 (15.83%) had SGA babies, 7 (5.83%) had LGA babies and 38 (31.66%) patients delivered by cesarean section. In this study, only 15% of the study population shows hypertensive disorder of pregnancy and had a statistically significant correlation with triglyceride level.10.83% of the study population had preterm delivery. It showed a statistically significant correlation with serum TG level.
Conclusions: Estimation of serum lipid profile during pregnancy can be considered as an early and economical investigation to prevent the deleterious effects of hyperlipidaemia associated with pregnancy.
Metrics
References
Nidhi D, Kaur B, Fayyaz S. Study of serum lipid profile in pregnancy and its correlation with preeclampsia. Obstet Gynecol Int J. 2019;10(3):169-74.
Vrijkotte TG, Krukziener N, Hutten BA, Vollebregt KC, van Eijsden M, Twickler MB. Maternal lipid profile during early pregnancy and pregnancy complications and outcomes: the ABCD study. J Clin Endocrin Metabol. 2012;97(11):3917-25.
Magnussen EB, Vatten LJ, Myklestad K, Salvesen KÅ, Romundstad PR. Cardiovascular risk factors prior to conception and the length of pregnancy: population-based cohort study. Ame J Obstetr Gynecol. 2011;204(6):526-e1.
Catov JM, Ness RB, Wellons MF, Jacobs DR, Roberts JM, Gunderson EP. Prepregnancy lipids related to preterm birth risk: the coronary artery risk development in young adults study. J Clin Endocrinol Metabol. 2010;95(8):3711-8.
Gluckman PD, Hanson MA, Cooper C, Thornburg KL. Effect of in utero and early-life conditions on adult health and disease. N Eng J Medi. 2008;359(1):61-73.
Gohil JT, Patel PK, Gupta P. Estimation of lipid profile in subjects of preeclampsia. J Obstet Gynecol India. 2011;61(4):399–403.
Kumari K, Singh U, Maharshi S, Singh R. Assessment of serum lipid profile in early pregnancy and its relation with pre eclampsia: a prospective study. Int J Reprod Contracep Obstet Gynecol. 2016;5(3):840-5.
Singh UB, Dwivedi S. To evaluate the status of serum lipid profile, β-hCG in pre-eclampsia compare with normal pregnancy-β-hCG as a predictor of preeclampsia. Int J Medi Heal Res. 2017;3(5):14-6.
Ghodke B, Pusukuru R, Mehta V. Association of lipid profile in pregnancy with preeclampsia, gestational diabetes mellitus, and preterm delivery. Cureus. 2017;9(7):e1420.
National Cholesterol Education Program (US). Expert Panel on Detection, Treatment of High Blood Cholesterol in Adults. Third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). The Program; 2002.
Kandimalla BH, Sirjusingh A, Nayak BS, Maiya SS. Early antenatal serum lipid levels and the risk of pre-eclampsia in Trinidad and Tobago. Arch Physiol Biochem. 2011;117(4):215-21.
Downloads
Published
How to Cite
Issue
Section
