A challenging case of prolactinoma in pregnancy

Authors

  • Sweta Sinha Department of Obstetrics and Gynecology, Pramukhswami Medical College, Karamsad, Anand, Gujarat, India
  • Riddhi Bhorania Department of Obstetrics and Gynecology, Pramukhswami Medical College, Karamsad, Anand, Gujarat, India
  • Dipal Shah Department of Obstetrics and Gynecology, Pramukhswami Medical College, Karamsad, Anand, Gujarat, India
  • Shilpa Sapre Department of Obstetrics and Gynecology, Pramukhswami Medical College, Karamsad, Anand, Gujarat, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20242086

Keywords:

Bitemporal hemianopia, Cabergoline, Lactotroph hyperplasia, Optic chiasma, Prolactinoma, Pregnancy, Transsphenoidal

Abstract

Prolactinomas are the most common functional tumour of pituitary gland arising from lactotrophs.  Microadenomas constitute 90% and the rest are macroadenomas. Females are more prone to develop macroadenomas. High estrogen levels during pregnancy leads to increase in the size of prolactinomas thereby leading to compression of optic chiasma. This eventually manifests as visual symptoms and headache. Pharmacotherapy with dopamine agonists is the treatment of choice. We present here a case of prolactinoma in a pregnant woman whose symptoms worsened due to increase in size of the tumor. Multidisciplinary management resulted in successful outcome.

 

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References

Yatavelli RKR, Bhusal K. Prolactinoma. In: StatPearls. Treasure Island (FL): StatPearls Publishing. 2024:459327.

Andre E Manov. Pituatary microadenomas. Medscape.2023.

Almalki MH, Alzahrani S, Alshahrani F, Alsherbeni S, Almoharib O, Aljohani N and Almagamsi A managing prolactinomas during pregnancy. Front Endocrinol. 2015;6:85.

Sirilert S,Traisrislip K,Pantasri T, Tongsong T .Pregnancy-induced progressive change of prolactin-secreting macroadenoma with the development of bitemporal hemianopia and severe headache. Clin Case Rep. 2019;7(7):1365-9.

Meled S, Casanueva FF, Hoffmann AR, Kleuberg DL, Montori VM, Schlechte JA. Diagnosis and treatment of hyperprolactinemia: an endocrine society clinical practice guideline. J Clin Endocrinol metab. 2011;96(2):273-88.

Molitch ME. Endocrinology in pregnancy: Management of pregnancy with prolactinoma. Eur J Endocrinol. 2015;72(5):205-13.

Chrisoulidou A, Boudina M, Karavitaki N, Bili E, Wass J. Pitutary disorders in pregnancy Hormones. 2015;14(1):70-80.

Auriemma RS, Perone Y, Disarno A, Grasso F, Guerra E, Gasperi M. Results of single centric observational 10-year survey study in recurrence of hyperprolactinemia after pregnancy and lactation. J clin Endocrinol Metab. 2013;98(1):372-9.

Laway AB, BABA MS, Bansiwal SK, Choh NA. Prolactinoma outcome after pregnancy and lactation. Indian Journal of Endocrinology and Metabolism. 2021;25(6):559-62.

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Published

2024-07-29

How to Cite

Sinha, S., Bhorania, R., Shah, D., & Sapre, S. (2024). A challenging case of prolactinoma in pregnancy. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 13(8), 2146–2148. https://doi.org/10.18203/2320-1770.ijrcog20242086

Issue

Section

Case Reports