DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20162110

Comparison between intravenous iron sucrose versus oral iron therapy in pregnant women with nutritional anemia: a prospective study

Archna Tandon, Vineeta Gupta, Priyanka Chaudhari, Nidhi Kumari

Abstract


Background: In India, the prevalence of anemia during pregnancy may be as high as 80%. The objective of this study was determining the efficacy of intravenous iron sucrose and oral iron in nutritional anemic antenatal patients, presenting at Shri Guru Ram Rai Institute of Medical and Health Sciences Dehradun, Uttarakhand, India.

Methods: The study was carried out in the department of obstetrics and gynecology, Shri Guru Ram Rai Institute of Medical and Health Sciences, Dehradun, Uttarakhand, India single center study was performed on 400 antenatal patients with nutritional anemia gestational age 14 to 36 weeks. Patients were divided in two groups A and B. Group A was treated with intravenous iron sucrose and group B was treated with oral iron sulfate.

Results: There was significant improvement in the various hematological parameters in IV sucrose group as compared to patients in oral iron group. There were no significant allergic reactions in IV sucrose group.

Conclusions: This study has shown a significant improvement in the iron sucrose group. Iron sucrose is safe and well tolerated.


Keywords


Iron sucrose, Anemic antitpartum women, Nutritional and iron deficiency anemia

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References


Sharma JB. Nutritional anaemia during pregnancy in non-industrialized countries: Progress in obstetrics and gynaecology. 2010;23(4):253-60.

Bayoumeu F, Subiran-Buisset C, Baka NE, Legagneur H, Monnier-Barbarino P, Laxenaire MC. Iron therapy in iron deficiency anemia in pregnancy: intravenous route versus oral route. American journal of obstetrics and gynecology. 2002:31;186(3):518-22.

Dede A, Uygur D, Yilmaz B, Mungan T, Uğur M. Intravenous iron sucrose complex versus oral ferrous sulfate for postpartum iron deficiency anemia. International Journal of Gynecology and Obstetrics. 2005;90(3):238-9.

Wali A, Mushtaq A. Comparative study efficacy, safety and compliance of intravenous iron sucrose and intramuscular iron sorbitol in iron deficiency anemia of pregnancy. JPMA. 2002;52(9):392-5.

Perewusnyk G, Huch R, Huch A, Breymann C. Parenteral iron therapy in obstetrics: 8 years’ experience with iron-sucrose complex. British journal of nutrition. 2002;88(1):3-10.

AI RA, Unlubilgin E, Kandermir O, Yalvac S, Cakir L, Haberai A. Intravenous versus oral iron for treatment of anemia in pregnancy: a randomized trial. Obstet Gynecol. 2005;106(6):1335-40.

Westad S, Backe B, Salvesen KÅ, Nakling J, Økland I, Borthen I, et al. A 12-week randomized study comparing intravenous iron sucrose versus oral ferrous sulphate for treatment of postpartum anemia. Acta obstetricia Et gynecologica Scandinavica. 2008;87(9):916-23.