Unraveling the enigma of preterm birth: maternal factors, interventions, and neonatal implications

Authors

  • Chhalak Mukundchandra Thakkar Department of Obstetrics and Gynecology, Dr MK Shah Medical College and Research Centre, Ahmedabad, Gujarat, India
  • Lalit D. Kapadia Department of Obstetrics and Gynecology, Dr MK Shah Medical College and Research Centre, Ahmedabad, Gujarat, India
  • Arti J. Patel Department of Obstetrics and Gynecology, Dr MK Shah Medical College and Research Centre, Ahmedabad, Gujarat, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20240477

Keywords:

Clinical interventions, Neonatal outcomes, Perinatal morbidity, Preterm birth, Preterm birth prevention

Abstract

Background: Preterm birth is a substantial global health issue with significant consequences to the newborn, family and society. Preterm deliveries affects nearly 15 million births worldwide.

Methods: A retrospective cross-sectional study, conducted in a tertiary healthcare center on 100 preterm births. The data used, was of a period of 6 months in 2023.

Results: The incidence of preterm was found to be 100 out of 791 live births (12.4%). Among which majority, (64%), fell into the moderate to late preterm range and with 40% falling within the 21-25 age group .While 41% had less than four antenatal care visits. Among the identified risk factors in the preterm births, high blood pressure and anemia were prevalent medical disorders, affecting 20 and 36 of cases, respectively. In obstetrical factors, 24 were attributed to multiple gestations. Lower socioeconomic status was a significant contributing factor, affecting 55 of the studied population. NICU admission ranged from short stays of 1-3 days (34%) to more extended durations, with 18% requiring care for 10-21 days and tocolytics were employed in 27 cases, with a notable 66.60% instances demonstrating effectiveness in preventing preterm birth.

Conclusions: In this study, we found high incidence of preterm birth (12.4%). Various socio-demographic, obstetric and neonatal risk factors were associated with preterm birth. Risk factor anticipation and timely interventions will help in the reduction of preterm births and associated mortalities.

References

Cunningham F, Leveno KJ, Dashe JS, Hoffman BL, Spong CY, Casey BM (Eds.), Williams Obstetrics, 26e. McGraw Hill; 2022.

Phillips C, Velji Z, Hanly C, Metcalfe A. Risk of recurrent spontaneous preterm birth: a systematic review and meta-analysis. BMJ open. 2017;7(6).

India Today. Premature Babies: Understanding the Preterm Birth Rate in India and Its Categories, 23 May 2023. Available at: https://www.indiatoday.in/diu/story/premature-babies-preterm-birth-rate-in-india-preterm-categories-2383091-2023-05-23. Accessed on 30 August 2023.

World Health Organization. Preterm Birth, 2023. https://www.who.int/news-room/fact-sheets/detail/preterm-birth. Accessed on 30 August 2023.

Gurung A, Wrammert J, Sunny AK, Gurung R, Rana N, Basaula YN, et al. Incidence, risk factors and consequences of preterm birth–findings from a multi-centric observational study for 14 months in Nepal. Arch Publ Health. 2020;78:1-9.

Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R, et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012;379(9832):2162-72.

Hui L, Marzan MB, Potenza S, Rolnik DL, Pritchard N, Said JM, et al. Increase in preterm stillbirths in association with reduction in iatrogenic preterm births during COVID-19 lockdown in Australia: a multicenter cohort study. Am J Obstet Gynecol 2022;227(3):491.e1-17

Chawanpaiboon S, Vogel JP, Moller AB, Lumbiganon P, Petzold M, Hogan D, et al. Global, regional, and national estimates of levels of preterm birth in 2014: a systematic review and modelling analysis. Lancet Glob Health. 2019;7(1):e37-46.

Terzidou V, Bennett PR. Preterm labour. Curr Opin Obstet Gynecol. 2002;14(2):105-13.

Georgiou HM, Di Quinzio MK, Permezel M, Brennecke SP. Predicting preterm labour: current status and future prospects. Dis Markers. 2015;2015:435014.

NICE. Preterm labour and birth: methods, evidence and recommendations. Guidelines. 2015;25.

Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet. 2008;371(9606):75-84.

Illanes SE, Pérez-Sepúlveda A, Rice GE, Mitchell MD. Preterm labour: association between labour physiology, tocolysis and prevention. Expert Opin Investig Drugs. 2014;23(6):759-71.

López Bernal A, TambyRaja RL. Preterm labour. Baillieres Best Pract Res Clin Obstet Gynaecol. 2000;14(1):133-53.

Stock S, Norman J. Preterm and term labour in multiple pregnancies. Semin Fetal Neonatal Med. 2010;15(6):336-41.

Downloads

Published

2024-02-27

Issue

Section

Original Research Articles