A comprehensive review on prevalence and its adverse outcome of Chlamydia trachomatis on female genital tract

Authors

  • Taniqsha Bambani RAK Medical and Health Sciences University, Ras al khamiah, United Arab Emirates
  • Ananya Srivastava RAK Medical and Health Sciences University, Ras al khamiah, United Arab Emirates
  • Sahina Saif RAK Medical and Health Sciences University, Ras al khamiah, United Arab Emirates
  • Noopur Kedia Department of Obstetrics and Gynecology, Aster D. M. Healthcare, Dubai

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20240498

Keywords:

Chlamydia, Pelvic inflammatory disease, Cervicitis, Sexually transmitted infections

Abstract

One of the most prevalent bacterial infections acquired through sexual contact is Chlamydia trachomatis. The age group of 16-19 years old (young sexually active individuals) is where females are most susceptible to contracting this virus. Most of the time they are asymptomatic, but if they are not treated, they might have serious side effects including pelvic inflammatory disease (PID). Chylamdia can be diagnosed using a variety of diagnostic methods; however, recent groundbreaking research using NAAT has made the diagnosis and treatment of the condition two times simpler. Key words such as ‘chlamydia,’ ‘pelvic inflammatory disease’ ‘cervicitis,’ ‘sexually transmitted infection,’ ‘vaginal discharge’ were used in a systematic search of the electronic databases PubMed, Embase, LitCovid, MedRxiv, BioRxiv, Google Scholar, EBSCO MEDLINE, CINAHL, and Scopus to find studies published between January 2009 and December 2023. Overall, this review helps to clarify the effects of Chylamdia on the female reproductive system, which in turn helps to clarify some of the problems and basic care associated with it. In general, the review's goal is to shield the public from serious health problems and make them more equipped to deal with them in case they acquire them.

 

Metrics

Metrics Loading ...

References

Hillis SD, Owens LM, Marchbanks PA, Amsterdam LF, Mac Kenzie WR. Recurrent chlamydial infections increase the risks of hospitalization for ectopic pregnancy and pelvic inflammatory disease. Am J Obstet Gynecol. 1997;176(1 Pt 1):103-7.

Paavonen J, Westrom L, Eschenbach D. Pelvic inflammatory disease. In: Holmes KK, Sparling PF, Stamm WE, eds. Sexually Transmitted Diseases. 4th ed. New York: McGraw-Hill; 2008: 1017-1050.

Jennings LK, Krywko DM. Pelvic Inflammatory Disease. StatPearls. 2024.

Hillier SL, Kiviat NB, Hawes SE, Hasselquist MB, Hanssen PW, Eschenbach DA, et al. Role of bacterial vaginosis-associated microorganisms in endometritis. Am J Obstet Gynecol. 1996;175(2):435-41.

Wang SP, Grayston JT. Immunologic relationship between genital TRIC, lymphogranuloma venereum, and related organisms in a new microtiter indirect immunofluorescence test. Am J Ophthalmol. 1970;70(3):367-74.

Fatholahzadeh B, Bahador A, Haghighi Hasanabad M, Bazarjani F, Haghighi F. Comparative screening of Chlamydia trachomatis infection in women population in tehran, iran. Iran Red Crescent Med J. 2012;14(5):289-93.

Wilkowska-Trojniel M, Zdrodowska-Stefanow B, Ostaszewska-Puchalska I, Redźko S, Przepieść J, Zdrodowski M. The influence of Chlamydia trachomatis infection on spontaneous abortions. Adv Med Sci. 2009;54(1):86-90.

Folger AT. Maternal Chlamydia trachomatis infections and preterm birth:the impact of early detection and eradication during pregnancy. Matern Child Health J. 2014;18(8):1795-802.

Haghighi Hasanabad M, Mohammadzadeh M, Bahador A, Fazel N, Rakhshani H, Majnooni A. Prevalence of Chlamydia trachomatis and Mycoplasma genitalium in pregnant women of Sabzevar-Iran. Iran J Microbiol. 2011;3(3):123-8.

Newman L, Rowley J, Vander Hoorn S, Wijesooriya NS, Unemo M, Low N, et al. Global Estimates of the Prevalence and Incidence of Four Curable Sexually Transmitted Infections in 2012 Based on Systematic Review and Global Reporting. PLoS One. 2015;10(12):e0143304.

Rein DB, Kassler WJ, Irwin KL, Rabiee L. Direct medical cost of pelvic inflammatory disease and its sequelae: decreasing, but still substantial. Obstet Gynecol. 2000;95(3):397-402.

Weström L. Decrease in incidence of women treated in hospital for acute salpingitis in Sweden. Genitourin Med. 1988;64(1):59-63.

Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance, 2014. Available at: http://www.cdc.gov/std/stats14/surv-2014. Accessed on 02 January 2024.

Crichton J, Hickman M, Campbell R, Batista-Ferrer H, Macleod J. Socioeconomic factors and other sources of variation in the prevalence of genital chlamydia infections: A systematic review and meta-analysis. BMC Public Health. 2015;15:729.

Darville T. Chlamydia spp. In: Nataro JP, Blaser MJ, Cunningham-Rundles S, eds. Persistent bacterial infections. Washington, DC: ASM Press; 2000: 229-261.

Beatty WL, Morrison RP, Byrne GI. Persistent chlamydiae: from cell culture to a paradigm for chlamydial pathogenesis. Microbiol Rev. 1994;58(4):686-99.

Wiesenfeld HC, Hillier SL, Meyn LA, Amortegui AJ, Sweet RL. Subclinical pelvic inflammatory disease and infertility. Obstet Gynecol. 2012;120(1):37-43.

Bailey RL, Natividad-Sancho A, Fowler A, Peeling RW, Mabey DC, Whittle HC, et al. Host genetic contribution to the cellular immune response to Chlamydia trachomatis: Heritability estimate from a Gambian twin study. Drugs Today (Barc). 2009;45:45-50.

Wendel PJ, Cox SM, Roberts SW, Dax J, Gilstrap LC. Chorioamnionitis: association of nonreassuring fetal heart-rate patterns and interval from diagnosis to delivery on neonatal outcome. Infect Dis Obstet Gynecol. 1994;2(4):162-6.

Ward ME, Ridgway G. Chlamydia. In: Collier L, Balows A, Sussman A, eds. Topley and Wilsons microbiology and microbial infection. 9th ed. New York: Oxford University Press Inc; 1999: 1331-1336.

Morré SA, Brule AJ, Rozendaal L, Boeke AJ, Voorhorst FJ, Blok S, et al. The natural course of asymptomatic Chlamydia trachomatis infections: 45% clearance and no development of clinical PID after one-year follow-up. Int J STD AIDS. 2002;13(2):12-8.

Malhotra M, Sood S, Mukherjee A, Muralidhar S, Bala M. Genital Chlamydia trachomatis: an update. Indian J Med Res. 2013;138(3):303-16.

Creighton S, Tenant-Flowers M, Taylor CB, Miller R, Low N. Co-infection with gonorrhoea and chlamydia: how much is there and what does it mean? Int J STD AIDS. 2003;14(2):109-13.

Klausner JD, McFarland W, Bolan G, Hernandez MT, Molitor F, Lemp GF, et al. Knock-knock: a population-based survey of risk behavior, health care access, and Chlamydia trachomatis infection among low-income women in the San Francisco Bay area. J Infect Dis. 2001;183(7):1087-92.

Rours GI, Verkooyen RP, Willemse HF, Zwaan EA, Belkum A, Groot R, et al. Use of pooled urine samples and automated DNA isolation to achieve improved sensitivity and cost-effectiveness of large-scale testing for Chlamydia trachomatis in pregnant women. J Clin Microbiol. 2005;43(9):4684-90.

Götz HM, van Oeffelen LA, Hoebe CJPA, van Benthem BH. Regional differences in chlamydia and gonorrhoeae positivity rate among heterosexual STI clinic visitors in the Netherlands: contribution of client and regional characteristics as assessed by cross-sectional surveillance data. BMJ Open. 2019;9(1):e022793.

Valkengoed IG, Morré SA, Meijer CJ, van den Brule AJ, Boeke AJ. Do questions on sexual behaviour and the method of sample collection affect participation in a screening programme for asymptomatic Chlamydia trachomatis infections in primary care? Int J STD AIDS. 2002;13(1):36-8.

Workowski KA, Bolan GA; Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015;64(RR-03):1-137.

Wiesenfeld HC, Hillier SL, Meyn LA, Amortegui AJ, Sweet RL. Subclinical pelvic inflammatory disease and infertility. Obstet Gynecol. 2012;120(1):37-43.

Spaulding AC, Miller J, Trigg BG, Braverman P, Lincoln T, Reams PN, et al. Screening for sexually transmitted diseases in short-term correctional institutions: summary of evidence reviewed for the 2010 Centers for Disease Control and Prevention Sexually Transmitted Diseases Treatment Guidelines. Sex Transm Dis. 2013;40(9):679-84.

Bachmann LH, Richey CM, Waites K, Schwebke JR, Hook EW. Patterns of Chlamydia trachomatis testing and follow-up at a University Hospital Medical Center. Sex Transm Dis. 1999;26(9):496-9.

Geisler WM, Wang C, Morrison SG, Black CM, Bandea CI, Hook EW. The natural history of untreated Chlamydia trachomatis infection in the interval between screening and returning for treatment. Sex Transm Dis. 2008;35(2):119-23.

Bakken IJ, Skjeldestad FE, Nordbø SA. Chlamydia trachomatis infections increase the risk for ectopic pregnancy: a population-based, nested case-control study. Sex Transm Dis. 2007;34(3):166-9.

Egger M, Low N, Smith GD, Lindblom B, Herrmann B. Screening for chlamydial infections and the risk of ectopic pregnancy in a county in Sweden: ecological analysis. BMJ. 1998;316(7147):1776-80.

Liu B, Roberts CL, Clarke M, Jorm L, Hunt J, Ward J. Chlamydia and gonorrhoea infections and the risk of adverse obstetric outcomes: a retrospective cohort study. Sex Transm Infect. 2013;89(8):672-8.

Hollegaard S, Vogel I, Thorsen P, Jensen IP, Mordhorst CH, Jeune B. Chlamydia trachomatis C-complex serovars are a risk factor for preterm birth. In Vivo. 2007;21(1):107-12.

Andrews WW, Goldenberg RL, Mercer B, Iams J, Meis P, Moawad A, et al. The Preterm Prediction Study: association of second-trimester genitourinary chlamydia infection with subsequent spontaneous preterm birth. Am J Obstet Gynecol. 2000;183(3):662-8.

Adachi K, Nielsen-Saines K, Klausner JD. Chlamydia trachomatis Infection in Pregnancy: The Global Challenge of Preventing Adverse Pregnancy and Infant Outcomes in Sub-Saharan Africa and Asia. Biomed Res Int. 2016;2016:9315757.

Rours IG, Hammerschlag MR, Ott A, De Faber TJ, Verbrugh HA, de Groot R, et al. Chlamydia trachomatis as a cause of neonatal conjunctivitis in Dutch infants. Pediatrics. 2008;121(2):e321-6.

Silva J, Cerqueira F, Medeiros R. Chlamydia trachomatis infection: implications for HPV status and cervical cancer. Arch Gynecol Obstet. 2014;289(4):715-23.

Paba P, Bonifacio D, Di Bonito L, Ombres D, Favalli C, Syrjänen K, et al. Co-expression of HSV2 and Chlamydia trachomatis in HPV-positive cervical cancer and cervical intraepithelial neoplasia lesions is associated with aberrations in key intracellular pathways. Intervirology. 2008;51(4):230-4.

Paavonen J, Karunakaran KP, Noguchi Y, Anttila T, Bloigu A, Dillner J, et al. Serum antibody response to the heat shock protein 60 of Chlamydia trachomatis in women with developing cervical cancer. Am J Obstet Gynecol. 2003;189(5):1287-92.

Vries HJ, Zingoni A, White JA, Ross JD, Kreuter A. 2013 European Guideline on the management of proctitis, proctocolitis and enteritis caused by sexually transmissible pathogens. Int J STD AIDS. 2014;25(7):465-74.

Sigle GW, Kim R. Sexually transmitted proctitis. Clin Colon Rectal Surg. 2015;28(2):70-8.

Mahony JB, Chernesky MA. Effect of swab type and storage temperature on the isolation of Chlamydia trachomatis from clinical specimens. J Clin Microbiol. 1985;22(5):865-7.

Lanjouw E, Ouburg S, de Vries HJ, Stary A, Radcliffe K, Unemo M. 2015 European guideline on the management of Chlamydia trachomatis infections. Int J STD AIDS. 2016;27(5):333-48.

Meyer T. Diagnostic Procedures to Detect Chlamydia trachomatis Infections. Microorganisms. 2016;4(3):25.

Centers for Disease Control and Prevention. Recommendations for the laboratory-based detection of Chlamydia trachomatis and Neisseria gonorrhoeae--2014. MMWR Recomm Rep. 2014;63(RR-02):1-19.

Johnson RE, Newhall WJ, Papp JR, Knapp JS, Black CM, Gift TL, et al. Screening tests to detect Chlamydia trachomatis and Neisseria gonorrhoeae infections--2002. MMWR Recomm Rep. 2002;51(RR-15):1-38.

Nwokolo NC, Dragovic B, Patel S, Tong CY, Barker G, Radcliffe K. 2015 UK national guideline for the management of infection with Chlamydia trachomatis. Int J STD AIDS. 2016;27(4):251-67.

Patton DL, Wølner-Hanssen P, Cosgrove SJ, Holmes KK. The effects of Chlamydia trachomatis on the female reproductive tract of the Macaca nemestrina after a single tubal challenge following repeated cervical inoculations. Obstet Gynecol. 1990;76(4):643-50.

Patton DL, Kuo CC. Histopathology of Chlamydia trachomatis salpingitis after primary and repeated reinfections in the monkey subcutaneous pocket model. J Reprod Fertil. 1989;85(2):647-56.

Blythe MJ, Katz BP, Batteiger BE, Ganser JA, Jones RB. Recurrent genitourinary chlamydial infections in sexually active female adolescents. J Pediatr. 1992;121(3):487-93.

Fortenberry JD, Evans DL. Routine screening for genital Chlamydia trachomatis in adolescent females. Sex Transm Dis. 1989;16(4):168-72.

CDC. 1998 Guidelines for Treatment of Sexually Transmitted Diseases, 2023. Available at: https://www.cdc.gov/mmwr/preview/mmwrhtml/00050909.htm. Accessed on 02 January 2024.

Cates W, Rothenberg RB, Blount JH. Syphilis control. The historic context and epidemiologic basis for interrupting sexual transmission of Treponema pallidum. Sex Transm Dis. 1996;23(1):68-75.

Kissinger P, Brown R, Reed K, Salifou J, Drake A, Farley TA, Martin DH. Effectiveness of patient delivered partner medication for preventing recurrent Chlamydia trachomatis. Sex Transm Infect. 1998;74(5):331-3.

Manavi K. A review on infection with Chlamydia trachomatis. Best Pract Res Clin Obstet Gynaecol. 2006;20(6):941-51.

AHM. Australian medicines handbook, 2011. Available at: https://shop.amh.net.au/. Accessed on 02 January 2024.

Centres for Disease Control and Prevention. Sexually Transmitted Diseases Treatment Guidelines, 2002. Available at: http://www.cdc.gov/std/treatment/5-2002TG.htm# PelvicInflammatoryDisea. Accessed on 02 January 2024.

Rahangdale L, Guerry S, Bauer HM, Packel L, Rhew M, Baxter R, et al. An observational cohort study of Chlamydia trachomatis treatment in pregnancy. Sex Transm Dis. 2006;33(2):106-10.

Jacobson GF, Autry AM, Kirby RS, Liverman EM, Motley RU. A randomized controlled trial comparing amoxicillin and azithromycin for the treatment of Chlamydia trachomatis in pregnancy. Am J Obstet Gynecol. 2001;184(7):1352-4.

Carter BL, Woodhead JC, Cole KJ, Milavetz G. Gastrointestinal side effects with erythromycin preparations. Drug Intell Clin Pharm. 1987;21(9):734-8.

Williams DA. Stevens-Johnson syndrome after erythromycin therapy while deployed at sea. Mil Med. 2000;165(8):636-7.

Berger FA, Weteringen W, Sijs H, Hunfeld NGM, Bunge JJH, Groot NMS, et al. Dynamics of the QTc interval over a 24-h dose interval after start of intravenous ciprofloxacin or low-dose erythromycin administration in ICU patients. Pharmacol Res Perspect. 2021;9(6):e00865.

1998 guidelines for treatment of sexually transmitted diseases. Centers for Disease Control and Prevention. MMWR Recomm Rep. 1998;47(RR-1):1-111.

Hooton TM, Batteiger BE, Judson FN, Spruance SL, Stamm WE. Ofloxacin versus doxycycline for treatment of cervical infection with Chlamydia trachomatis. Antimicrob Agents Chemother. 1992;36(5):1144-6.

Downloads

Published

2024-02-27

How to Cite

Bambani, T., Srivastava, A., Saif, S., & Kedia, N. (2024). A comprehensive review on prevalence and its adverse outcome of Chlamydia trachomatis on female genital tract. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 13(3), 768–775. https://doi.org/10.18203/2320-1770.ijrcog20240498

Issue

Section

Review Articles