Association of metabolic syndrome with gestational hypertension

Authors

  • Nowsheen Khan Department of Obstetrics and Gynecology, SKIMS MCH Bemina, Jammu and Kashmir, India
  • Syed Basit Department of Obstetrics and Gynecology, SKIMS MCH Bemina, Jammu and Kashmir, India
  • Danish Ahmed Department of Obstetrics and Gynecology, GMC Anantnag, Jammu and Kashmir, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20240780

Keywords:

Eclampsia, Gestational hypertension, Metabolic syndrome, Pre-eclampsia

Abstract

Background: Metabolic syndrome is a group of clinical, metabolic and biochemical abnormalities with negative impact on global health. The aim of the study was to determine the association between metabolic syndrome and pregnancy induced hypertension, and incidence and effects of metabolic syndrome in pregnant patients.

Methods: Prospective observational study, performed in the Department of Obstetrics and Gynecology, Holy Family Hospital, New Delhi. Antenatal women before 20 weeks of gestation were enrolled in the study. Metabolic syndrome was diagnosed by utilizing the pregnancy adaptation of MeS criteria of NCEPATP III laboratory and clinical criteria. Cases were followed throughout pregnancy to observe their progression into hypertensive disorders of pregnancy i.e. gestational hypertension, pre-eclampsia and eclampsia.

Results: Out of 100 cases with metabolic syndrome 37% developed PIH, 21 developed pre-eclampsia and 14 developed gestational hypertension, 2 patients developed eclampsia as compared to controls in which only 10% developed PIH among which only 3% developed pre-eclampsia.

Conclusions: Our study demonstrates a higher rate of complicated pregnancy with higher incidence of PIH in association with metabolic syndrome compared to control group. Each component of metabolic syndrome increases the probability of PIH. The addition of components of metabolic syndrome exacerbates this probability, especially the combination of increased BMI, increased blood sugar levels and increased triglycerides.

References

Hernández-Camacho JD, Hernández-Camacho M. Clinical update on metabolic syndrome. Revista Español Nutrición Huma Dietét. 2017;21(4):384-92.

Expert Panel on Detection E. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). Jama. 2001;285(19):2486-97.

The International Diabetes Federation. Consensus worldwide definition of the metabolic syndrome. Available at: https://www.idf.org/e-library/consensus-statements/60-idfconsensus-worldwide-definitionof-the-metabolic-syndrome.html. Accessed 03 February, 2020.

Nijdam ME, Timmerman MR, Franx A, Bruinse HW, Numans ME, Grobbee DE, et al. Cardiovascular risk factor assessment after pre-eclampsia in primary care. BMC Fam Pract. 2009;10(1):1-6.

Ferranti EP, Jones EJ, Hernandez TL. Pregnancy reveals evolving risk for cardiometabolic disease in women. J Obstet Gynecol Neonat Nurs. 2016;45(3):413-25.

Barry DR, Utzschneider KM, Tong J, Gaba K, Leotta DF, Brunzell JD, et al. Intraabdominal fat, insulin sensitivity, and cardiovascular risk factors in postpartum women with a history of preeclampsia. Ame J Obstet Gynecol. 2015;213(1):104-e1.

Forest JC, Girouard J, Massé J, Moutquin JM, Kharfi A, Ness RB, et al. Early occurrence of metabolic syndrome after hypertension in pregnancy. Obstet Gynecol. 2005;105(6):1373-80.

Carr DB, Newton KM, Utzschneider KM, Tong J, Gerchman F, Kahn SE, et al. Preeclampsia and risk of developing subsequent diabetes. Hyperten Pregnan. 2009;28(4):435-47.

Paramsothy P, Knopp RH. Metabolic syndrome in women of childbearing age and pregnancy: Recognition and management of dyslipidemia. Metab. Syndr. Relat. Disord. 2008;3(3):250-8.

Bentley-Lewis R, Koruda K, Seely EW. The metabolic syndrome in women. Nat Clin Pract Endocrinol Metab. 2007;3(10):696-704.

Limo MD, Melo AS, Sena AS, Barros VD, Amorim MM. Metabolic syndrome in pregnancy and postpartum: prevalence and 20associated factors. Revi Associ Médi Brasil. 2019;65(12):1489-95.

Wani K, Sabico S, Alnaami AM, Al-Musharaf S, Fouda MA, Al-Ajlan A, et al. Early-pregnancy metabolic syndrome and subsequent incidence in gestational diabetes mellitus in Arab women. Front Endocrinol. 2020;11:503139.

Vladutiu CJ, Siega-Riz AM, Sotres-Alvarez D, Stuebe AM, Ni A, Tabb KM, et al. Parity and components of the metabolic syndrome among US Hispanic/Latina women: results from the hispanic community health study/study of Latinos. Circulation: Cardiovascular Quality and Outcomes. 2016;9(2_suppl_1):S62-9.

Horvath B, Bodecs T, Boncz I, Bodis J. Metabolic syndrome in normal and complicated pregnancies. J Metabol Syndr Relat Disor. 2013;11(3):185-8.

Musharaf S , Malik S, Gupta N. Risk factors for cesarean delivery in patients of gestational diabetes mellitus at a tertiary care centre - a descriptive observational study. Europ J Mole Clin Medi. 2020;7(11):8146-52.

Leddy MA, Power ML, Schulkin J. The impact of maternal obesity on maternal and fetal health. Rev Obstet Gynecol. 2008;1(4):170-8.

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Published

2024-03-28

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Original Research Articles