A prospective study on the outcome of pregnancies with a history of prior single or multiple early pregnancy losses

Authors

  • Mosam R. Patel Dr. M. K. Shah Medical College and Research Centre, Ahmedabad, Gujarat, India
  • Niketankumar Rathod Dr. M. K. Shah Medical College and Research Centre, Ahmedabad, Gujarat, India
  • Jalpa K. Bhatt Dr. M. K. Shah Medical College and Research Centre, Ahmedabad, Gujarat, India
  • Manishkumar K. Patel Dr. M. K. Shah Medical College and Research Centre, Ahmedabad, Gujarat, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20241072

Keywords:

Pregnancy outcome, Maternal, Fetal, Complications, Recurrent pregnancy loss, First trimester abortion, Miscarriage

Abstract

Background: In spite of the fact that a history of first-trimester recurrent spontaneous abortion (FRSA) is regarded as a risk factor in antenatal care, the characteristic of consequent pregnancy outcome isn’t clearly illustrated.

Methods: A prospective observational analysis was performed on the clinical data of 100 singleton pregnant women.

Results: For maternal outcomes, patients within study group delivered prior with mean gestational age and the incidences of Caesarean section and postpartum haemorrhage were higher. For placental outcomes, the incidence of placenta-mediated pregnancy complications (PMPC) within study group increased in terms of late-onset preeclampsia, oligohydramnios, early-onset fetal growth restriction, and second-trimester abortion. For perinatal outcomes, the proportion of birth abandons of newborns within study group was even higher. At last, logistic regression analyses appeared that the history of FRSA was an autonomous risk factor for caesarean section and pregnancy complications.

Conclusions: Women with the history of FRSA are often exposed to an elevated incidence of maternal-placental-perinatal adverse pregnancy outcomes.

References

Upadhyay C, Koregol M, Bulusu R, Dubey S, Shah N. Obstetric outcome of pregnancies following abortions. J Evol Med Dent Sci. 2013;2(31):5755-8.

Cao C, Bai S, Zhang J, Sun X, Meng A, Chen H. Understanding recurrent pregnancy loss: recent advances on its etiology, clinical diagnosis, and management. Med Rev (2021). 2022;2(6):570-89.

Yang J, Wang Y, Wang XY, Zhao YY, Wang J, Zhao YY. Adverse Pregnancy Outcomes of Patients with History of First-Trimester Recurrent Spontaneous Abortion. Biomed Res Int. 2017;4359424.

Kashanian M, Akbarian AR, Baradaran H, Shabandoust SH. Pregnancy outcome following a previous spontaneous abortion (miscarriage). Gynecol Obstet Invest. 2006;61(3):167-70.

Sheiner E, Levy A, Katz M, Mazor M. Pregnancy outcome following recurrent spontaneous abortions. Eur J Obstet Gynecol Reprod Biol. 2005;118:61-5.

Reginald PW, Beard RW, Chapple J, Forbes PB, Liddle HS, Mowbray JF. Outcome of pregnancies progressing beyond 28 weeks gestation in women with history of recurrent miscarriage. Br J Obstet Gynecol. 1987;94:643-8.

Brigham SA, Conlon C, Farquharson RG. A longitudinal study of pregnancy outcome following idiopathic recurrent miscarriage. Human Reprod. 1999; 4(11):2868-71.

Wu J, Lin S, Huang P, Qiu L, Jiang Y, Zhang Y, et al. Maternal anxiety affects embryo implantation via impairing adrenergic receptor signaling in decidual cells. Commun Biol. 2022;5(1):840.

Sultana S, Nallari P, Ananthapur V. Recurrent pregnancy loss (RPL): an overview. J Women’s Health Dev. 2020;03:302-15.

Agrawal S, Khoiwal S, Jayant K, Agarwal R. Predicting adverse maternal and perinatal outcome after threatened miscarriage. Open J Obstet Gynecol. 2014;4:1-7.

Regan L, Braude PR, Trembath PL. Influence of past reproductive performance on risk of spontaneous abortion. BMJ. 1989;299:541-5.

Clifford K, Rai R, Regan L. Future pregnancy outcome in unexplained recurrent first trimester miscarriage. Human Reproduction. 1997;12(2):387-9.

Saccone G, Schoen C, Franasiak JM, Scott RT Jr, Berghella V. Supplementation with progestogens in the first trimester of pregnancy to prevent miscarriage in women with unexplained recurrent miscarriage: a systematic review and meta-analysis of randomized, controlled trials. Fertil Steril. 2017;107(2):430-8.

Bhattacharya S, Lowit A, Bhattacharya S, Raja EA, Lee AJ, Mahmood T, et al. Reproductive outcomes following induced abortion: a national register-based cohort study in Scotland. BMJ Open. 2012;2(4):e000911.

Cunningham FG. Abortion. Williams Obstetrics. 2014;24(18):350-65.

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Published

2024-04-26

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Original Research Articles