A study of platelet disorders in pregnancy


  • Uma Pandey Department of Obstetrics and Gynaecology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India




Thrombocytopenia, Postpartum haemorrhage, Preeclampsia, ITP, HELLP, DIC


Background: Thrombocytopenia is low platelet count, if present during pregnancy can jeopardize the maternal and fetal outcome. Thrombocytopenia affects 6-15% of pregnancies. Causes of thrombocytopenia include gestational, idiopathic thrombocytopenia, preeclampsia, HELLP, DIC, malignancy and marrow failure.

We planned to do this study to find out common causes of thrombocytopenia in our hospital and management being used.

Methods: Data was collected form those women who came to the antenatal clinic (booked) and labour room (unbooked) in the department of obstetrics and gynaecology, Sir Sunder Lal hospital, institute of medical sciences, Banaras Hindu University. Data of a total of 67 pregnant women were collected during the period of July 2012 to June 2015.

Results: There were 74.62% cases of gestational thrombocytopenia, 10.44% related to preeclampsia, 4.47% in Eclamptic patients, 1.49% in HELLP and DIC, 5.97% in ITP, and lastly 1.49% in malaria cases. There were number of associated complication whether directly related (PPH) or part of the disorder. PPH was observed in 22.38% which is maximum among all complications. Other complications were part of major associated illness i.e. liver failure (7.46%), renal failure (4.47%), DIC (4.47%) and HELLP (7.46%).

Conclusions: Mode of delivery was not influenced by platelet count, but for obstetric indications. Management of patients was as per the diagnosis. Single donor plasma is preferable to random donor plasma. PPH was the commonest complication and we should be wary of that.


Boehlen F. Thrombocytopenia during pregnancy. Importance, diagnosis and management. Hamostaseologie. 2006;26(1):72-4.

Stirling Y, Woolf L, North WR, Seghatchian MJ, Meade TW. Haemostasis in normal pregnancy. Thromb Haemostas. 1984;52:176-82.

Matthews JH, Benjamin S, Gill DS, Smith NA. Pregnancy associated thrombocytopenia: definition, incidence and natural history. Acta Haematol Basel. 1990;84:24-9.

Fenton V, Saunders K, Cavillet I. The platelets count in pregnancy. J Clin Path. 1977;30:68-9.

Shehata N, Burrows RF, Kelton JG. Gestational thrombocytopenia. Clin Obstet Gynecol. 1999;42:327-34.

American College of Obstet Gynecol. ACOG practice bulletin: diagnosis and management of preeclampsia in pregnancy. Obstet Gynecol. 2002;99:159-67.

Barton JR, Sibai BM. Diagnosis and management of hemolysis, elevated liver enzymes and low platelets syndrome. Clin Perinatology. 2004;31:807-33.

Sullivan CA, Martin JN. Management of the obstetric patient with thrombocytopenia. Clin Obstet Gynecol. 1995;38(3):521-34.

Provan D, Stasi R, Newland AC, Blanchette VS, Maggs PB, Bussel JB, et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood. 2010;115:168-86.






Original Research Articles