DOI: http://dx.doi.org/10.18203/2320-1770.ijrcog20170608

Anaplastic ganglioglioma becoming symptomatic in the third trimester of pregnancy

Stylianos Pikis, Tigran Petrosyan, Kalliopi Diamantopoulou, Christos Kelesis

Abstract


Intracranial tumors are rare in pregnancy and may present a diagnostic and therapeutic challenge. We report on a 34-year-old female who presented with new-onset partial seizures hours following delivery due to a left frontal space occupying lesion. Urgent surgical resection of the lesion was performed and histopathologic evaluation revealed anaplastic ganglioglioma. Post-operatively the patient received radiotherapy and temozolamide chemotherapy. She reported a three-month history of progressive headache and nausea which were falsely attributed to pregnancy both by the patient and her treating physician leading to a delay in diagnosis and management. In the pregnant patient presenting with neurological symptoms a high index of suspicion and a thorough physical examination is required to identify those patients at risk of intracranial pathology.


Keywords


Anaplastic ganglioglioma, Brain tumor, Diagnosis, Pregnancy

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References


Ravindra VM, Braca III JA, Jensen RL, Duckworth EA. Management of intracranial pathology during pregnancy: Case example and review of management strategies. Surg Neurol Int. 2015;6:43.

Lucas Jr JT, Huang AJ, Mott RT, Lesser GJ, Tatter SB, Chan MD. Anaplastic ganglioglioma: a report of three cases and review of the literature. J Neuro-oncol 2015;123(1):171-7.

Knafo S, Goutagny S, Pallud J. Increased growth rate of a WHO grade I ganglioglioma during pregnancy. British J Neurosurg. 2013;27(1):119-121.

Pikis S, Cohen JE, Rosenthal G, Barzilay Y, Kaplan L, Shoshan Y, et al. Spinal meningioma becoming symptomatic in the third trimester of pregnancy. J Clin Neurosci. 2013;20(12):1797-9.