Fetomaternal outcome in abnormal liquor volume pregnancies


  • Narra Madhuri Department of Obstetrics and Gynaecology, Jhargram Govt Medical College and Hospital, Jhargram, West Bengal, India
  • Chayan Kumar Pal Department of Orthopaedics, Govt. Medical College Anantapur, Anantapur, Andhra Pradesh, India https://orcid.org/0009-0006-9664-3802
  • Parthapratim Sharma Department of Orthopaedics, Govt. Medical College Anantapur, Anantapur, Andhra Pradesh, India




Polyhydramnios, Amniotic fluid index, Oligohydramnios, NICU admission, Caesarean section


Background: Variation in the amniotic fluid reflects fetal compromise, and congenital anomalies and also may predict perinatal morbidity and mortality.

Methods: Singleton pregnancy subjects with well-established dates at ≥28 weeks of gestational age were taken into study. These subjects were ultrasonographically diagnosed to have abnormal liquor volumes. This study was a hospital-based single-center prospective observational study conducted in Midnapore medical college and hospital, west Bengal. The chi-square test was applied for statistical significance and a p<0.05 was considered to be significant.

Results: In all subjects of abnormal liquor volume, the incidence of oligohydramnios and polyhydramnios are in the proportion of 3:1 in our study. Postdated pregnancy (28.4%), hypertensive disease (16.8%), intrauterine growth restriction (IUGR) (12.6%), and anemia (2.2%) were associated with oligohydramnios. Congenital anomalies (23.3%), GDM (16.6%), and Rh-incompatibility (3.3%) were associated with polyhydramnios. The incidence of caesarean section, meconium-stained liquor and 5-minute APGAR score <7 and NICU admission was higher in the oligohydramnios group as compared to polyhydramnios. In abnormal liquor volume, the statistical association was significant with onset of labour (p=0.00), mode of delivery (p=0.00), the colour of liquor(p-0.00), and fetal outcome (p=0.00).

Conclusions: Postdated pregnancy, IUGR, and hypertensive disorders were associated with oligohydramnios and congenital anomalies, and GDM and Rh-isoimmunization were associated with polyhydramnios. In abnormal liquor volume onset of labour, mode of delivery, the colour of the liquor, and fetal outcome were significant.


James DK, Steer PJ, Weiner CP, Gonik B. High-risk pregnancy and management options, 4th edition. Philadelphia: Saunders/Elsevier publications. 2010;197-207.

Cunningham F, Kenneth L, Steven B, John H, Dwight R, Catherine S. Williams Obstetrics, 23rd edition. New York: McGraw-Hill publications. 2009;490-99.

Guin G, Punekar S, Lele A, Khare S. A prospective clinical study of feto-maternal outcome in pregnancies with abnormal liquor volume. J Obstetr Gynecol India. 2011;61(6);652-5.

Gaddis GM, Gaddis ML. Introduction to biostatistics: Part 4, statistical inference techniques in hypothesis testing. Ann Emergency Med. 1990;19(7):820-5.

Patra P. Sample size in clinical research, the number we need. Int J Med Sci Publ Heal. 2012;1(1):5-10.

Rao PS, Richard J. An Introduction to Biostatistics: A manual for students in health sciences. Prentice/Hall of India. 1996.

Dharamaraj BK, Shamanewadi A. Maternal and perinatal outcome in oligohydramnios in oligohydramnios: a study from a tertiary care hospital, Bangalore, Karnataka, India. IJRCOG. 2016:5(7):2291-4.

Anisodowleh Nankali, Maryam Hermatti, Alireza Talebi. Fetomaternal Outcomes in Cases of Term Oligohydramnios. Women’s Health Gynecol. 2017;3(3):1-3.

Vidyasagar V, Chutani N. Fetomaternal outcome in cases of oligohydramnios after 28 weeks of pregnancy. IJRCOG. 2015;4(1):152.

Kaur T, Sood R. Fetomaternal outcome in pregnancies with abnormal AFI. J Dental Med Sci. 2016;15:17-75.

Bangal VB, Giri PA, Shinde KK, Gavhane SP. Vaginal birth after caesarean section. North Am J Med Sci 2013;5:140-4.

Asgharnia M, Faraji R. Perinatal outcomes of pregnancies with borderline versus normal amniotic fluid index. Iran J Reprod Med. 2013;11:705-10.

Tashfeen K, Hamdi IM. Polyhydramnios as a predictor of adverse pregnancy outcomes. Sultan Qaboos Univ Med J. 2013;13(1):57-62.

Jagatia K, Singh N, Patel S. Maternal and Fetal Outcome in Oligohydramnios: A Study of 100 Cases. Int J Med Sci Public Health. 2013;2(3):724-7.

Zhang J, Troendle J. Isolated oligohydramnios is not associated with adverse perinatal outcome. Int J Gynaecol Obstet. 2004;3:220-5.

Hsieh TT, Hung TH, Chen KC, Hsieh CC, Lo LM, Chiu TH. Perinatal outcome of oligohydramnios without associated premature rupture of membranes and fetal anomalies. Gynecol Obstet Invest. 1998;45(4):232-6.

Morris JM, Thompson K, Smithey J, Gaffney G, Cooke I, Chamberlain P, et al. The usefulness of ultrasound assessment of amniotic fluid in predicting adverse outcome in prolonged pregnancy: a prospective blinded observational study. Br J Obstet Gynaecol. 2003;110(11):989-94.

Rutherford SE, Phelan JP, Smith CV, Jacobs N. The four quadrant assessment of amniotic fluid volume: an adjunct to antepartum fetal heart rate testing. Obstet Gynecol. 1987;70(3):353-6.

Bhagat M, Chawla I. Correlation of Amniotic Fluid Index with Perinatal Outcome. Available at: http://www.jogi.co.in.2014.64:1. Accessed on 21 February, 2024.

Chauhan SP, Sanderson M, Hendrix NW, Magann EF, Devoe LD. Perinatal outcome and amniotic fluid index in the antepartum and intrapartum periods: a meta-analysis. Am J Obstet Gynaecol. 1999;181(6):1473-8.

Driggers RW, Holcraft CJ, Blakemore KJ, Ernest MG. An amniotic fluid index <5 cm within 7 days of delivery in the third trimester is not associated with decreasing umbilical arterial pH and base excess. J Perinatol. 2004;24(2):72-6.

Grubb DK, Paul RH. Amniotic fluid index and prolonged antepartum fetal heart rate decelerations. Obstet Gynecol. 1992;79(4):558-60.

Karim R, Jabeen S, Pervaiz F, Wahab S, Yasmeen S, Raees M. Decreased amniotic fluid index and adverse pregnancy outcome at term. JPMI. 2010;24(04);307-11.

Syria R, Singhal S, Rajan M, Sharman M, Nagel P. Perinatal outcome in patients with AFI<5 cm. J Obstet Gynecol India. 2001;51:98-100.

Casey BM. Pregnancy outcome after antepartum diagnosis of oligohydramnios at or beyond 34 weeks gestation. Am J Obstet Gynaecol. 2000;182:909-12.

Mishra S, Ghatak S, Agrawal D, Singh P, Garg PK. Estimation of Fetal Weight: An Ultrasonography Study in Indian Population. Mymensingh Med J. 2020;29(1):215-21.






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