Xanthogranulomatous endometritis: a benign mimicker of malignancy

Authors

  • Roshni Chandramouli Department of Obstetrics and Gynaecology, Vijaya Hospital, Vadapalani, Chennai, Tamil Nadu, India
  • Niranjana Rajan Department of Obstetrics and Gynaecology, Vijaya Hospital, Vadapalani, Chennai, Tamil Nadu, India
  • Venkatachalam Veerappan Department of Obstetrics and Gynaecology, Vijaya Hospital, Vadapalani, Chennai, Tamil Nadu, India
  • Dhanalakshmi Venkatesan Department of Obstetrics and Gynaecology, Vijaya Hospital, Vadapalani, Chennai, Tamil Nadu, India
  • Partheeban Balasundaram Pathologist, SIMS Hospital, Vadapalani, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20241790

Keywords:

Xanthogranulomatous endometritis, Malignancy, Granulation tissue

Abstract

Xanthogranulomatous endometritis is a pathological entity which has an unusual characteristic of partial or complete replacement of the mucosa by granulation tissue with plenty of foamy histiocytes, sidero blasts and multinucleated giant cells. This condition clinically and radiologically mimics an endometrial carcinoma, which might create panic in patients as well as healthcare professionals. Hence it is important for Gynaecologists and pathologists to be aware of this condition so as to differentiate it from malignancy. Coexisting malignancy too is a possibility to be ruled out. We report case of a 69-year-old for whom we had high suspicion for malignancy based on clinical and radiological features, hence surgical oncologist opinion was obtained and total laparoscopic hysterectomy+bilateralsalpingo-oophorectomy and frozen section was performed-reported as inflammatory reaction. Hence, further oncological procedure (lymphadenectomy and omentectomy) was abandoned. The final Histopathology was reported as xanthogranulomatous endometritis. We are publishing this case report due to rarity(<30 cases reported worldwide) and its close resemblance to malignancy clinically and radiologically.

 

References

Jaiman S, Gundabattula SR, Dasari S, Pochiraju M. Atypical xanthogranulomatous inflammation of the female genital tract. EJOG. 2018;222:186-7.

Na JM, Kim MH, Ko GH, Shin JK. Xanthogranulomatous endometritis: a report of two Korean cases with cytologic findings. J Pathol Transl Med. 2020;54(6):513-6

Malik V, Chatterjee D, Goel B, Takkar N. Xanthogranulomatous Endometritis: A Benign Uncommon Masquerader of Malignancy. J Midlife Health. 2019;10(4):206-8.

Rani E, Suri V, Sandhu J, Goel N, Kaur P. Xanthogranulomatous endometritis- a rare pathological entity presenting as infertility. Tropical Journal of Pathology and Microbiology. 2019;5(12):1050-3.

Kumar N, Lakra PS, Sinha RK, Roy AD, Saha D, Sinha JK. Xanthogranulomatous endometritis with calculus formation in setting of prolapsed uterus. Autops Case Rep. 2023;13:e2023439.

Russack V, Lammers RJ. Xanthogranulomatous endometritiss. Report of six cases and a proposed mechanism of development. Arch Pathol Lab Med. 1990;114(9):929-32.

Anandathirtha K, Shabnam Z, Manjeera L. Xanthogranulomatous endometritis with unilateral salpingo-oophoritis in a postmenopausal woman masquerading as a malignancy. BMJ Case Reports CP. 2023;16:e247341.

Buckley CH, Fox H. Histiocytic endometritis. Histopathology. 1980;4(1):105-10.

Merviel P, James P, Carlier M, Thomas-Kergastel I, Guilloique M, Conan-Charlet V, et al. Xanthogranulomatous endometritis: A case report and literature review. Clin Case Rep. 2021;9(6):e04299.

Downloads

Published

2024-06-27

Issue

Section

Case Reports