Evaluating the efficacy of Dfrag tablets on human sperm DNA fragmentation - insights from a prospective clinical study

Mala Raj; Roobini J.; Aarathy Kasturiraj

doi:10.18203/2320-1770.ijrcog20241772

Authors

Mala Raj Infertility Specialist, Endoscopic Surgeon, Firm Hospitals, Chennai, Tamil Nadu, India
Roobini J. Clinical Embryologist, Firm Hospitals, Chennai, Tamil Nadu, India
Aarathy Kasturiraj Clinical Embryologist, Firm Hospitals, Chennai, Tamil Nadu, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20241772

Keywords:

Early clinical exposure, Knowledge, Medical education, Medical students

Abstract

Background: Infertility affects approximately 8-10% of couples worldwide. Sperm deoxyribonucleic acid (DNA) fragmentation index (DFI) has emerged as a significant factor in infertility research, highlighting its importance in understanding reproductive health.

Methods: This prospective clinical study aimed to assess the impact of Dfrag® tablets, a unique nutraceutical combination containing vitamin D3 (600 IU), selenomethionine (40 mcg), coenzyme Q10 (100 mg), and astaxanthin (8 mg), on high sperm DFI over a 3-month period. The study utilized the sperm chromatin dispersion test (SCD) to measure DFI and examined semen parameters before and after the intervention.

Results: Dfrag® tablets were found to significantly improve semen volume, total sperm count, sperm concentration, and progressive motility within the 3-month treatment period. The study reported an average reduction of 36% in DNA fragmentation levels post-treatment with Dfrag® tablets. However, no significant changes were observed in total motility or sperm morphology.

Conclusions: This study demonstrates the potential of Dfrag® tablets in reducing sperm DNA fragmentation and improving key semen parameters associated with fertility.

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