Genitourinary syndrome of menopause exploring the history, updates and treatment
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20241607Keywords:
GUS, Vulvovaginal atrophy, Urogenital atrophy, Menopausal symptoms, Vaginal health index, Vaginal maturity indexAbstract
The biological factors and physiological functions fundamental to the female anatomy delineate the complexity of reproductive phenomenon in this population. When women experience menopausal transition, genital, sexual, and urinary signs and symptoms materialize often. These longstanding signs and symptoms, presently referred to as the genitourinary syndrome (GUS) of menopause, a relatively new term, impact their quality of life and sexual health with the emergence of vulvovaginal and urogenital atrophy, typical of irritation, soreness, dryness, dyspareunia, and itching. Despite its prevalence, GUS of menopause often goes unreported due to embarrassment, leading to underdiagnoses, diminished intervention, and under-treatment. Moreover, the rising life expectancy is also emerging as a contributing factor to the increasing prevalence of GUS of menopause, directly affecting women's health. While there are notable awareness, education, and healthcare frameworks in place aimed at addressing the unique needs of menopausal women, there is a need to explore further GUS’ prevalence, pathophysiology, risk factors, clinical features, diagnosis, and treatment to understand, diagnose, and effectively manage this condition.
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References
Gandhi J, Chen A, Dagur G, Smith N, Cali V. Genitourinary Syndrome of Menopause: An Overview of Clinical Manifestations, Pathophysiology, Etiology, Evaluation, and Management. Am J Obstet Gynecol. 2016;215(6):704-11.
Phillips NA, Bachmann GA. The Genitourinary Syndrome of Menopause. Menopause. 2021;28(5):579-88.
Wasnik VB, Acharya N, Mohammad S. Genitourinary Syndrome of Menopause: A Narrative Review Focusing on Its Effects on the Sexual Health and Quality of Life of Women. Cureus. 2023;15(11):1-10.
Singh A, Srivastava R, Aditya V. Prevalence and Determinants of Genitourinary Syndrome among Postmenopausal Women of Eastern UP: A Cross Sectional Study. Int J Health Sci Res. 2021;11(5):1-7.
Zhu Y, Wei J, Yang X, Zhu W, Zhang W. Investigation on Prevalence and Risk Factors Associated with Genitourinary Syndrome of Menopause in Middle-Aged and Older Women in Beijing Community: A Cross Sectional Study. BMC Women’s Health. 2022;22(558):1-8.
Angelou K, Grigoriadis T, Diakosavvas M, Zacharakis D, Athanasiou S. The Genitourinary Syndrome of Menopause: An Overview of the Recent Data. Cureus. 2020;12(4):1-9.
Christmas M, Huguenin A, Iyer S. Clinical Practice Guidelines for Managing Genitourinary Symptoms Associated with Menopause. Clin Obstet Gynecol. 2023;67(1):101-14.
Libretti S, Aeddula NR. Embryology, Genitourinary. PubMed. StatPearls Publishing. 2021.
Sarmento ACA, Costa APF, Vieira-Baptista P, Giraldo PC, Eleutério J, Gonçalves AK. Genitourinary Syndrome of Menopause: Epidemiology, Physiopathology, Clinical Manifestation and Diagnostic. Front Reprod Health. 2021;3:1-6.
Kim HK, Kang SY, Chung YJ, Kim JH, Kim MR. The Recent Review of the Genitourinary Syndrome of Menopause. J Menopausal Med. 2015;21(2):65-71.
World Health Organization. Menopause. Available at: https://www.who.int/news-room/fact-sheets/detail/ menopause#Public%20Health%20Challenges%20Related%20to%20Menopause. Accessed on 12 April 2024.
Nik Hazlina NH, Norhayati MN, Shaiful Bahari I, Nik Muhammad Arif NA. Prevalence of Psychosomatic and Genitourinary Syndrome among Menopausal Women: A Systematic Review and Meta-Analysis. Front Med. 2022;9:1-11.
Marino JM. Genitourinary Syndrome of Menopause. J Midwifery Women’s Health. 2021;66(6):65-71.
Moral E, Delgado JL, Carmona F. Genitourinary Syndrome of Menopause. Prevalence and Quality of Life in Spanish Postmenopausal Women. The GENISSE Study. Climacteric. 2018;21(2):167-73.
Ojha N, Bista KD, Bajracharya S, Katuwal N. Genitourinary Syndrome of Menopause among Postmenopausal Women in a Tertiary Care Centre: A Descriptive Cross-sectional Study. J Nepal Med Assoc. 2022;60(246):126-31.
Hassanein MM, Huri HZ, Baig K, Abduelkarem AR, Al-Momani M. Development and Validation of the Genitourinary Syndrome of Menopause Symptoms and Vaginal Treatments Acceptability Questionnaire (GSM‐SVTAQ): An Electronic Patient‐Reported Outcomes Measure. Int J Gynaecol Obstet. 2023;164(2):613-23.
Tariq B, Phillips S, Biswakarma R, Talaulikar V, Harper J. Women’s Knowledge and Attitudes to the Menopause: A Comparison of Women over 40 Who Were in the Perimenopause, Post Menopause and Those Not in the Peri or Post Menopause. BMC Women’s Health. 2023;23(1):1-16.
Gabrieli D, Suissa-Cohen Y, Jaber S, Lev-Sagie A. “Modified Schirmer Test” as an Objective Measurement for Vaginal Dryness: A Prospective Cohort Study. Diagnostics. 2022;12(3):1-8.
Iyer TK, Thacker HL. Menopause. In Falcone T, Hurd WW, Editors. Clinical reproductive medicine in surgery. Springer. 2022;201-33.
North American Menopause Society. The 2020 Genitourinary Syndrome of Menopause Position Statement of the North American Menopause Society. Menopause. 2020;27(9):976-92.
Da Silva AS, Baines G, Araklitis G, Robinson D, Cardozo L. Modern Management of Genitourinary Syndrome of Menopause. Faculty Rev. 2021;10(25):1-11.
Kagan R, Kellogg-Spadt S, Parish SJ. Practical Treatment Considerations in the Management of Genitourinary Syndrome of Menopause. Drugs Aging. 2019;36(10):897-908.
Palacios S, Combalia J, Emsellem C, Gaslain Y, Khorsandi D. Therapies for the Management of Genitourinary Syndrome of Menopause. Post Reprod Health. 2019;26(1):32-42.
López DML. Management of Genitourinary Syndrome of Menopause in Breast Cancer Survivors: An Update. World J Clin Oncol. 2022;13(2):71-100.
McAdams E, Cross Z, Bosch C, Rodriguez JE, Nashelsky J. Treatments for Postmenopausal Hypoactive Sexual Desire Disorder. Am Fam Physician. 2020;101(3):182-3.
Kim SH, Park ES, Kim TH. Rejuvenation Using Platelet-rich Plasma and Lipofilling for Vaginal Atrophy and Lichen Sclerosus. J Menopausal Med. 2017;23(1):63.
Naumova I, Castelo-Branco C. Current Treatment Options for Postmenopausal Vaginal Atrophy. Int J Women’s Health. 2018;10:387-95.
Waghe T, Acharya N, Karnik M, Mohammad S, Patel NA, Gemnani R. Role of Platelet-Rich Plasma in Genitourinary Syndrome of Menopause. Curēus. 2024;16(1):1-6.