Contribution of various factors to male infertility: a prospective review

Authors

  • Amrit Kaur Bansal Department of Zoology, Mata Ganga Khalsa College (Affiliated to Panjab University, Chandigarh) Manji Sahib, Kottan, Ludhiana, Punjab, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20242845

Keywords:

Male infertility, Spermatozoa, Oligospermia, Sperm count, Varicocele

Abstract

Infertility is becoming a serious problem among present generation. It causes emotional instability and mental stress in affected couples. In half of the analysed cases, male factor infertility is the major contributor. Despite numerous efforts by researchers to identify various causes of male infertility, about 70 % causes remain unknown. This is due to lack of understanding of mechanisms involved in male infertility. The present review focuses on the abnormalities in male reproductive structures and contribution of endocrinological, immunological and developmental factors to male factor infertility.

Metrics

Metrics Loading ...

References

Gnoth C, Godehardt E, Frank-Herrmann P, Friol K, Tigges J, Freundl G. Definition and prevalence of subfertility and infertility. Hum Reprod. 2005;20:1144-7.

Briceag I, Costache A, Purcarea V. Fallopian tubes–literature review of anatomy and etiology in female infertility. J Med Life. 2015;8(2):129.

Kumar N, Singh AK. Trends of male factor infertility, an important cause of infertility: a review of literature. J Hum Reprod Sci. 2015;8(4):191.

Goldstein M, Eid JF. Elevation of intratesticular and scrotal skin surface temperature in men with varicocele. J Urol. 1989;142:743-45.

Raheem AA and Ralph D. Male infertility causes and investigations. Trend in Urology and Men’s Health. 2011;2:1-4.

Desai N, Sharma R, Makker K, Sabanegh E, Agarwal A. Physiologic and pathological levels of reactive oxygen species in neat semen of infertile men. Fertil Steril. 2009:92(5);1626-31.

Shah KM, Gamit KG, Raval MA, Vyas NY. Male infertility: A scoping review of prevalence, causes and treatments. Asian Pac J Repr. 2021;10(5):195-202.

Tsoumanis A, Hens N, Kenyon CR. Is screening for Chlamydia and gonorrhoea in men who have sex with men associated with reduction of the prevalence of these infections. A systematic review of observational studies. Sex Transm Dis. 2018;45(9):615-22.

Lotti F, Maggi M. Sexual dysfunction and male infertility. Nat Rev Urol. 2018:15(5):287.

Agbaje IM, Rogers DA, Mc-Vicar CM, McClure N, Atkinson AB. Insulin dependent diabetes mellitus: Implications for male reproductive functions. Hum Reprod. 2007;22:1871-7.

Jarzabek K, Zbucka M, Pepinski W. Cystic fibrosis as a cause of infertility. Reprod Biol. 2004;4(2):119-29.

Krausz C, Riera-Escamilla A. Genetics of male infertility. Nat Rev Urol. 2018;15(6):369-84.

Vog P, Edelmann A, Kirsch S. Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Y q11.Hum Mol Genet. 1996;5(7):933-43.

Hopps C, Mielink A, Goldstein M, Palermo G, Rosenwaks Z, Schegel P. Detection of sperm in men with Y chromosome microdeletions of the AZFa, AZF band AZFc regions. Human Reprod. 2003;18(8):1660-5.

Foresta C, Moro E, Ferlin A. Y chromosome microdeletions and alterations of spermatogenesis. Endocr Rev. 2001;22(2):226-39.

Dong Y, DuRc, Jiang YT, Wu J, Li LL, Liu R Z. Impact of chromosomal translocation on male infertility, semen quality, testicular, volume and reproductive hormone levels. J Int Med Res. 2012;40(6):2274-83.

Anway MD, Cupp AS, Vzumcu M, Skinner MK. Epigenetic transgenerational action of endocrine disruptors and male fertility. Science. 2005;308:1466-9.

Lombardo F. Immunology and immunopathology of the male genital tract. Anti sperm immunity in natural and assisted reproduction. Hum Reprod Update. 2001:7(5)450-6.

Babakhanzadeh E, Nazari M, Ghasemifar S, Khodadadian A. Some of the factors involved in male infertility: A prospective review. Int J Gen Med. 2020;13:29-41.

Sharma A. Male infertility: Evidence, risk factor, causes, diagnosis and management in human. Ann Clin Lab Res. 2017;5(03):1-10.

Vijayalakshmi J, Venkatchalam P, Paul SF, Usha RG, Kumarasamy P, Kanan J. Chromosomal anomalies in patients with azoospermia and oligoasthenoteratozoospermia. Int J Hum Genet .2011;11(2):117-21.

Bayasgalan G, Naranbat D, Radnaabazar J. Male infertility. Risk factors in Mongolian men. Asian J Andr. 2004;6:305-11.

Downloads

Published

2024-09-26

How to Cite

Bansal, A. K. (2024). Contribution of various factors to male infertility: a prospective review. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 13(10), 2969–2973. https://doi.org/10.18203/2320-1770.ijrcog20242845

Issue

Section

Review Articles