Published: 2017-01-11

Rare incidence of yolk sac tumor in pregnancy posing management challenge: a case report

Chanda Rai, Harsha Shailesh Gaikwad, Rohini Gupta


Yolk sac tumor of the ovary, although rare but highly malignant, when diagnosed in a pregnant woman is difficult to manage because of risks involved to the fetus but with the advent of surgery and chemotherapy prognosis has greatly improved.A G3P2L2, 35 years old, woman got admitted at 8 months amenorrhea with absent fetal movements since two days with labor pains. She carried an ultrasound report, done at a private clinic which showed intrauterine death of fetus along with a pelvic tumor. Her CT done at our hospital confirmed a pelvic tumor mass posterior to the uterus and in close proximity with the rectum. A laparotomy was planned for her as the pelvic mass was preventing the descent of fetal head thus hindering vaginal delivery. Biopsy from the tumor mass revealed yolk sac tumor of the ovary. Her general condition was poor with low Hb levels and deranged LFT and KFT and was shifted to ICU for intensive care but she could not survive despite the best efforts.Early diagnosis of ovarian yolk sac tumor in pregnancy leads to timely intervention in the forms of surgery and chemotherapy which greatly improves the survival rates.


Yolk, Pregnant, Tumor, Ovary

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Zanotti KS, Belinson JL, Kennedy AW. Treatment of gynecologic cancers in pregnancy. Semin Oncol. 2000;27:686-98.

Smith HO, Berwick M, Verschraegen CF, Charles W, Letitia L, Muller CY, et al. Incidence and survival rates for female malignant germ cell tumors. Obstet Gynecol. 2006;107(5):1075-85.

Bakri YN, Ezzet A, Dohami, Zahrani A. Malignant germ cell tumors of the ovary. Pregnancy considerations. Eur J Obstet Gynecol Reprod Biol. 2000;90:87-91.

Williams S, Blessing JA, Liao SY, Ball H, Hanjani H. Adjuvant therapy of ovarian germ cell tumors with cisplatin, etoposide, and bleomycin: a trial of the Gynecologic Oncology Group. J Clin Oncol. 1994;12:701-6.

Teilum G. Endodermal sinus tumors of the ovary and testis. Comparative morphogenesis of the so-called mesonephroma ovarii (Schiller) and extraembryonic (yolk sac-allantoic) structures of the rat's placenta. Cancer. 1959;12:1092-105.