Serum uric acid levels during pregnancy: a predictive marker for hypertensive disorders in antenatal women

Darshan Sankhe; Varsha D. Kose; Anuja Bhalerao

doi:10.18203/2320-1770.ijrcog20242291

Authors

Darshan Sankhe Department of Obstetrics and Gynaecology, NKP Institute of Medical Sciences, Nagpur, Maharashtra, India
Varsha D. Kose Department of Obstetrics and Gynaecology, NKP Institute of Medical Sciences, Nagpur, Maharashtra, India
Anuja Bhalerao Department of Obstetrics and Gynaecology, NKP Institute of Medical Sciences, Nagpur, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20242291

Keywords:

Hypertensive disorders of pregnancy, Preeclampsia, Feto-maternal outcome, Serum uric acid level

Abstract

Hypertensive disorders of pregnancy i.e., gestational hypertension, preeclampsia and eclampsia, are most common medical disorders of pregnancy and have serious implications on feto-maternal health outcomes. Owing to substantial risk to both mother and baby, one of emerging area of interest is the role of serum uric acid levels as a potential predictor of hypertensive disorders during pregnancy, notably preeclampsia. This comprehensive review focuses on role of serum uric acid levels, as a prescient marker for hypertensive complications in pregnant women. The review included the original research articles studying role of serum uric acid early detection of hypertensive disorders of pregnancy in pregnant women with gestational age >20 weeks. Original articles having primary data of study of predictive markers of hypertensive disorders of pregnancy were reviewed thoroughly for their demographic indicators, serum uric acid level and feto-maternal outcome of pregnancy. All the studies showed a significant high serum uric acid level among pre-eclamptic women compared to normotensive or pregnant women with gestational hypertension. The ROC also showed greater sensitivity and specificity compared to other markers such as serum calcium and serum creatinine. To conclude, this comprehensive review underscores the pivotal role of serum uric acid levels in predicting adverse maternal and fetal outcomes during pregnancy. This valuable insight has the potential to significantly enhance the care and outcomes for pregnant women and their unborn children facing hypertensive disorders.

Metrics

Metrics Loading ...

References

World Health Organization. Make every mother and child count. World Heal Rep. 2005. Geneva: WHO; 2005.

Bainbridge SA, Roberts JM. Uric acid as a pathogenic factor in preeclampsia. Placenta. 2008;29:67-72.

Johnson RJ, Kanbay M, Kang DH, Sánchez-Lozada LG, Feig D. Uric acid: a clinically useful marker to distinguish preeclampsia from gestational hypertension. Hypertension. 2011;58:548-9.

Kang DH, Finch J, Nakagawa T, Karumanchi SA, Kanellis J, Granger J, et al. Uric acid, endothelial dysfunction and pre-eclampsia: searching for a pathogenetic link. J Hypertens. 2004;22(2):229-35.

Niraula A, Lamsal M, Majhi S, Khan SA, Basnet P. Significance of Serum Uric Acid in Pregnancy Induced Hypertension. J Natl Med Assoc. 2017;109(3):198-202.

Kumar N, Singh AK. Maternal serum uric acid as a predictor of severity of hypertensive disorders of pregnancy: a prospective cohort study. Curr Hypertens Rev. 2019;15(2):154-60.

Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, et al. Is there a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension (Dallas, Tex. 1979). 2003;41(6):1183-90.

Livingston JR, Brown M, Roberts JM, Côté AM, Magee LA, Dadelszen P. Uric Acid as a predictor of adverse maternal and perinatal outcomes in women hospitalized with preeclampsia. J Obstet Gynaecol Can. 2014;36:870-7.

Ju DH, Lee H, Ha SJ. The presence of hypertension during pregnancy determines the future risk of metabolic syndrome: An observational study. Medicine (Baltimore). 2022;101(42):31272.

Monte S. Biochemical markers for prediction of preeclampsia: review of the literature. J Prenat Med. 2011;5(3):69-77.

Kondareddy T, Prathap T. Uric acid as an important biomarker in hypertensive disorders in pregnancy. Int J Reprod Contracept Ob stet Gynecol. 2016;5:4382-4.

Zangana JM, Hamadamen AI. Serum uric acid as a predictor of perinatal outcome in women with pre-eclampsia. Int J Med Res Health Sci 2018;7(3):168-74.

Vyakaranam S, Bhongir AV, Patlolla D, Chintapally R. Study of serum uric acid and creatinine in hypertensive disorders of pregnancy. Int J Med Sci public Heal. 2015;4(10):1424-8.

Asgharnia M, Mirblouk F, Kazemi S, Pourmarzi D, Mahdipour KM, Dalil HSF. Maternal serum uric acid level and maternal and neonatal complications in preeclamptic women: A cross-sectional study. Int J Reprod Biomed. 2017;15(9):583-8.

Tesfa E, Munshea A, Nibret E, Mekonnen D, Sinishaw MA, Gizaw ST. Maternal serum uric acid, creatinine and blood urea levels in the prediction of pre-eclampsia among pregnant women attending ANC and delivery services at Bahir Dar city public hospitals, northwest Ethiopia: A case-control study. Heliyon. 2022;8(10):1098.

Niyonzima FN, Dusabimana A, Mutijima JB. Pregnancy induced hypertension and uric acid levels among pregnant women attending ruhengeri referral hospital, in Rwanda. East African Heal Res J. 2021;5(1):44-9.