Association of increased platelet distribution width and red cell distribution width with recurrent pregnancy loss

Authors

  • Rajani Meena Department of Obstetrics and Gynecology, Sawai Man Singh Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India
  • Mohan Lal Meena Department of Obstetrics and Gynecology, Sawai Man Singh Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India
  • Priyanka Meena Department of Obstetrics and Gynecology, Sawai Man Singh Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India
  • Renu Meena Department of Obstetrics and Gynecology, Sawai Man Singh Medical College and Attached Group of Hospitals, Jaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20170589

Keywords:

Platelet distribution width, Recurrent pregnancy loss, Red cell distribution width

Abstract

Background: Recurrent pregnancy loss is defined as three or more consecutive pregnancy losses at or less than 20 weeks of gestation or with a fetal weight less than 500 grams. The aim was to compare platelet distribution width and red cell distribution width between pregnant women with a history of recurrent pregnancy loss and pregnant women without a history of pregnancy loss.

Methods: This was a prospective study to the evaluation of 70 pregnant women with a history of recurrent pregnancy loss and 70 pregnant women without a history of pregnancy loss in the first trimester.

Results: When compared pregnant women with a history of recurrent pregnancy loss and 70 pregnant women without a history of pregnancy loss, the pregnant women with a history of recurrent pregnancy loss had significantly higher platelet distribution width and red cell distribution width (p≤0.001 for both). There was no statistically significant difference between the two groups in terms of age, BMI, Hemoglobin, TLC, hematocrit, platelecrit, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration (p>0.05).

Conclusions: An increased platelet distribution width and red cell distribution width with recurrent pregnancy loss.

References

Cunningham FG, Leveno KJ, Bloom SL, Hauth JC. Abortion. In: Williams Obstetrics. 24th Ed. McGraw-Hill Medical; 2010:358-9.

Berek JS, Abaid LN, Anderson JR, Aubuchon M. Recurrent pregnancy loss. In: Berek and Novak’s Gynecology. 15th ed. Lippincott Williams and Wilkins; 2015:1190.

Christiansen OB, Nybo AAM, Bosch E. Evidence-based investigations and treatments of recurrent pregnancy loss. Fertil Steril. 2005;83:821-39.

Battinelli EM, Bauer KA. Thrombophilias in pregnancy. Hematol Oncol Clin North Am. 2011;25:323-33.

Colman-Brochu S. Deep vein thrombosis in pregnancy. MCN Am J Matern Child Nurs. 2004;29:186-92.

Robertson L, Wu O, Langhorne P. Thrombophilia in pregnancy: A systematic review. Br J Haematol. 2006;132:171-96.

D’Uva M, Di Micco P, Strina I, De Placido G. Recurrent pregnancy loss and thrombophilia. J Clin Med Res. 2010;2:18-22.

Gaussem P. Assessment of platelet function in man. Therapie. 2006;61:395-400.

Joly B, Barbay V, Borg JY, Le Cam-Duchez V. Comparison of markers of coagulation activation and thrombin generation test in uncomplicated pregnancies. Thromb Res. 2013;132:386-91.

Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: A simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14:28-32.

Ntaios G, Gurer O, Faouzi M, Aubert C, Michel P. Hypertension is an independent predictor of mean platelet volume in patients with acute ischemic stroke. Intern Med J. 2011;41:691-5.

Chu SG, Becker RC, Berger PB. Mean platelet volume as a predictor of cardiovascular risk: A systematic review and meta-analysis. J Thromb Haemost. 2010;8:148-56.

Colkesen Y, Acil T, Abayli B. Mean platelet volume is elevated during paroxysmal atrial fibrillation: A marker of increased platelet activation? Blood Coagul Fibrinolysis. 2008;19:411-4.

Cholada Vejabhuti Curry,Eris B staros.Red cell distribution width. 2015. Available at: emedicine.medscape.com.

Curry CV, Staros EB. Mean corpuscular volumne. 2015. Available at: emedicine.medscape.com.

Aynioglu O, Isik H, Harma MI, Isik M, Kokturk F. Can Platelecrit be a marker for recurrent pregnancy loss? Clin Appl Thromb Hemostat. 2014;22(5):447-52

Uysal RA, İncebıyık A, Hacıvelioğlu S, Gencer M, Güngör A, Çanakkale EC. Is There Any Relationship between Platelet Functions, Red Cell Distribution Width and Recurrent Pregnancy Loss? J Clin Anal Med. 2015;6(2):149-51.

Avcioğlu SN, Altinkaya SÖ, Küçük M. Sezer SD, Yüksel H. The Association between Platelet Indices and clinical parameters in recurrent pregnancy loss. Gynecol Obstet Reprod Med. 2014;20:146-9.

Downloads

Published

2017-02-19

Issue

Section

Original Research Articles