A study on the clinical and social aspects of polycystic ovarian syndrome in women of reproductive age group conducted at a specialized medical facility

Authors

  • Priyanka Sekhasaria Department of Obstetrics and Gynaecology, Pacific Medical College and Hospital Udaipur, Rajasthan, India
  • Akanksha Agrawal Department of Obstetrics and Gynaecology, Pacific Medical College and Hospital Udaipur, Rajasthan, India
  • Rama Singh Chundawat Department of Obstetrics and Gynaecology, Pacific Medical College and Hospital Udaipur, Rajasthan, India
  • Rajrani Sharma Department of Obstetrics and Gynaecology, Pacific Medical College and Hospital Udaipur, Rajasthan, India
  • Balveer Jakhar Department of Obstetrics and Gynaecology, Pacific Medical College and Hospital Udaipur, Rajasthan, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20243018

Keywords:

Acne, Excessive hair growth, Trouble, Irregular periods, PCOS, Infertility

Abstract

Background: Polycystic ovarian syndrome (PCOS) is seen as a complex illness that can present in women of various ages, including teenagers and post-menopausal women, not just those of childbearing age. The prevalence of PCOS in India ranges from 3.8% to 22.4% in most studies. The updated diagnostic criteria in Rotterdam consensus conferences now require the presence of two of the following: irregular periods, signs of excess male hormones, polycystic ovaries on ultrasound, and ruling out other possible causes like congenital adrenal hyperplasia, androgen-secreting tumors, and Cushing syndrome.

Methods: The research was carried out on women in the reproductive age category who have PCOS and were visiting the gynecology department at Pacific medical college and hospital in Udaipur. This is prospective comparative study/descriptive cross-sectional study. A total of 150 women were part of the sample. Research was conducted to investigate the correlation between PCOS and the socio-demographic characteristics of the patient.
Results: The mean age of participants in the research was 21.68 years, with a deviation of 4.2 years. Approximately 72% are burdened by excess weight, 22% suffer from acne, 21% encounter fertility issues, 6% have amenorrhea, 80% struggle with oligomenorrhea, and 26% are classified as obese. Acne is present in 23% of the participants in the research. Around 38% of people showed signs of hirsutism.

Conclusions: Research revealed a notably high occurrence of PCOS among females aged 21 to 30, with an average age of 23. These females were from a moderate socio-economic background and resided in urban areas, with most of them being students and homemakers leading sedentary lives. The most common clinical symptoms of PCOS in women were noted to be oligomenorrhea, weight gain, infertility, hirsutism, and acne.

References

Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. J Nat Rev Endocrinol. 2011;7(4):219-31.

Lizneva D, Gavrilova-Jordan L, Walker W, Azziz R. Androgen excess: Investigations and management. Best Pract Res Clin Obstet Gynaecol. 2016;37:98-118.

Ferriman D, Gallwey JD. Clinical assessment of body hair growth in women. J Clin Endocrinol Metabol. 1961;21(11):1440-7.

Schmidt TH, Keshav K, Marcelle IC, Heather H, Lauri P, Erica TW, et al. Cutaneous Findings and Systemic Associations in Women With Polycystic Ovary Syndrome. J Am Med Assoc Dermatol. 2016;152(4):391-8.

Diamanti-Kandarakis E, Dunaif A. Revisiting insulin resistance and polycystic ovary syndrome: an update on mechanisms and implications. Endocr Rev. 2012;33(6):981-1030.

Lim SS, Davies MJ, Norman RJ, Moran LJ. A systematic review and meta-analysis on overweight, obesity, and central obesity in women suffering from polycystic ovary syndrome. J Human Reprod Update. 2012;18(6):618-37.

Sam S. The relationship between excess body fat and metabolic issues in women with polycystic ovary syndrome. Horm Mole Biol Clin Investigation. 2015;21(2):107-16.

Ehrmann DA, Barnes RB, Rosenfield RL, Cavaghan MK, Imperial J. Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care. 1999;22(1):141-6.

Franks S, McCarthy MI, and Hardy K. The development of polycystic ovarian syndrome is influenced by both genetic and environmental factors. Int J Androl. 2006;29(1):278-85.

Gill H, Tiwari P, Dabadghao P. Survey conducted in North India shows high rates of polycystic ovarian syndrome in young women. Of or relating to India. J Endocrinol Metabolism. 2012;16(2):S389-92.

Mohammad MB, Seghinsara M. Polycystic ovary syndrome (PCOS), its diagnostic criteria, and Anti-Müllerian hormone (AMH). Asian Pac J Canc Prevent. 2017;18(1):17-21.

Sheehan MT. Diagnosis and treatment of polycystic ovarian syndrome. Clin Med Res J. 2004;2(1):13-27.

Azziz R. The comprehensive task force report on the criteria for polycystic ovary syndrome by the Androgen Excess and PCOS Society. Fertil Steril. 2009;91(2):456-88.

Legro RS. Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metabol. 2013;98(12):4565-92.

Balen AH. Polycystic ovary syndrome: the range of the condition in a total of 1741 patients. Human Reprod. 1995;10(8):2107-11.

Sirmans SM. Epidemiology, diagnosis, and treatment of polycystic ovary syndrome. Clin Epidemiol. 2013;6:1-13.

Azziz R, Keslie SW, Rosario R, Timothy JK, Eric SK, Bulent OY. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metabol. 2004;89(6):2745-9.

Diamanti-Kandarakis, Athanasios GP, Stylianos AK, George PC. Pathophysiology and types of dyslipidemia in PCOS. Trends Endocrinol Metabol. 2007;18(7):280-5.

Helvaci N, Karabulut E, Demir AU, Yildiz BO. Polycystic ovary syndrome and the risk of obstructive sleep apnea: a meta-analysis and review of the literature. Endocr Connect. 2017;6(7):437-445.

Randeva HS, Bee KT, Martin OW, Konstantinos L, John EN, Naveed S, et al. Cardiometabolic aspects of the polycystic ovary syndrome. Endocr Rev. 2012;33(5):812-41.

The Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks associated with polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41-7.

Teede HJ, Marie LM, Michael FC, Anuja D, Joop L, Lisa M, et al. Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertil Sterili. 2018;110(3):364-79.

Azziz R, Enrico C, ZiJiang C, Andrea D, Joop SEL, Richard SL, et al. Polycystic ovaries syndrome. Nat Rev Dis Primers. 2016;2(1):16057.

Clark AM, Ledger W, Galletly C, Tomlinson L, Blaney F, Wang X, et al. Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women. Hum Reprod. 1995;10(10):2705-12.

Yildiz BO. Approach to the patient: contraception in women with polycystic ovary syndrome. J Clin Endocrinol Metabol. 2015;100(3):794-802.

Zhao J, Xiaoyan L, Wenhua Z. The Effect of Metformin Therapy for Preventing Gestational Diabetes Mellitus in Women with Polycystic Ovary Syndrome: A Meta-Analysis. Exp Clin Endocrinol Diabetes. 2020;128(3):199-205.

Martin KA, Anderson RR, Chang RJ, Ehrmann DA, Lobo RA, Murad MH, et al. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metabolism. 2018;103(4):1233-57.

Child's DS, Hamilton-Fairley D, Bush A, Short F, Anyaoku V, Reed MJ, et al. Improvement in endocrine and ovarian function during dietary treatment of obese women with polycystic ovary syndrome. Clin Endocrinol (Oxford). 1992;36(1):105-11.

The National Institute for Health and Care Excellence focuses on evaluating and providing treatment for fertility issues. Guidance Document CG156. 2017.

Roque M, Ana CIT, Marcello V, Marcos S, Selmo G. Letrozole versus clomiphene citrate in polycystic ovary syndrome: systematic review and meta-analysis. Endocrinol Gynecol. 2015;31(12):917-21.

Sonak M, Rathod PD, and Patankar US were the authors. A prospective observational study of polycystic ovarian syndrome among adolescent and young girls at tertiary care hospital. Int J Reprod Contracept Obstetr Gynecol. 2022;11(9):2487-93.

Shinde KS, Patil SS. Incidence and risk factors of polycystic ovary syndrome among women in reproductive age group attending a tertiary health care hospital in Western Maharashtra. Int J Reprod Contracept Obstet Gynecol. 2019;8(7):2804-9.

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Published

2024-10-18

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Original Research Articles