Fetomaternal outcome of newly detected thyroid disorders among pregnant women in tertiary care hospital: a cross sectional study

Authors

  • Shanmuga Sundari Panneer Selvam Department of Obstetrics and Gynecology, Hassan Institute of Medical Sciences, Hassan, Karnataka, India
  • Manjunatha Shivanna Department of Obstetrics and Gynecology, Hassan Institute of Medical Sciences, Hassan, Karnataka, India
  • Ragupathi Krishnegowda Department of Obstetrics and Gynecology, Hassan Institute of Medical Sciences, Hassan, Karnataka, India
  • Suma H. Rangaswamy Department of Obstetrics and Gynecology, Hassan Institute of Medical Sciences, Hassan, Karnataka, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20250507

Keywords:

Hypothyroidism, Hyperthyroidism, Pregnancy complications, Neonatal outcome

Abstract

Background: Thyroid hormones are vital for fetal development and maternal health. Both overt and subclinical thyroid disorders can lead to complications like miscarriage, preterm labor, and neonatal issues. Identifying newly detected thyroid disorders in pregnancy is crucial for improving outcomes for both mothers and babies.

Methods: This cross-sectional study evaluated pregnant women newly diagnosed with thyroid disorders at a tertiary care hospital. Data on thyroid function, pregnancy complications, and neonatal health were collected and analyzed to assess the impact of these disorders. The findings aimed to enhance diagnostic methods and patient care.

Results: In our study, out of 150 cases, 148 were subclinical hypothyroidism, and 2 were subclinical hyperthyroidism. Subclinical hypothyroidism in pregnancy was associated with PPH (0.7%), preeclampsia (21.3%), preterm labor (9.3%), GDM (6.7%), IUD (3.3%), neonatal death (2.7%), prematurity (12.7%), LBW (21.3%), NICU admission (28%), congenital anomalies (2%), and neonatal hypothyroidism (11.3%). These findings were consistent with other studies; however, the number of hyperthyroid cases in our study was insufficient for a thorough outcome analysis.

Conclusions: Thyroid disorders during pregnancy can negatively impact both maternal and fetal outcomes, underscoring the need for routine antenatal thyroid screening.

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References

Vanes NK, Lazarus JH, CHAN SY. Thyroid function in pregnancy: maternal and fetal outcomes with hypothyroidism and subclinical thyroid dysfunction. Fetal Mater Medi Rev. 2011;22(3):169-87. DOI: https://doi.org/10.1017/S096553951100009X

Sreelatha S, Nadagoudar S, Devi AL. The study of maternal and fetal outcome in pregnant women with thyroid disorders. Int J Reprod Contracept Obstet Gynecol. 2017;6(8):3507-13. DOI: https://doi.org/10.18203/2320-1770.ijrcog20173473

Mahadik K, Choudhary P, Roy PK. Study of thyroid function in pregnancy, its feto-maternal outcome; a prospective observational study. BMC Pregn Childbirth. 2020;20(1):769. DOI: https://doi.org/10.1186/s12884-020-03448-z

Marx H, Amin P, Lazarus J. Hyperthyroidism and pregnancy. BMJ. 2008;336:663-7. DOI: https://doi.org/10.1136/bmj.39462.709005.AE

Gholami S, Namiranian N, Shukohifar M, Kalantari F, Azizi R. Maternal thyroid function test level during the first trimester of pregnancy at a center Yazd, Iran: A cross-sectional study. Int J Reprod Biomed. 2021;19(3):255-60. DOI: https://doi.org/10.18502/ijrm.v19i3.8573

Faki F, Dabbaghmanesh MH, Ghaemi SZ, Forouhari S, Ranjbar Omrani G, Bakhshayeshkaram M. Thyroid function in pregnancy and its influences on maternal and fetal outcomes. Int J Endocrinol Metab. 2014;12(4):e19378. DOI: https://doi.org/10.5812/ijem.19378

Ramprasad M, Bhattacharyya SS, Bhattacharyya A. Thyroid disorders in pregnancy. Indian J Endocrinol Metab. 2012;16(Suppl 2):S167-70. DOI: https://doi.org/10.4103/2230-8210.104031

Su PY, Huang K, Hao JH, Xu YQ, Yan SQ, Li T, et al. Maternal thyroid function in the first twenty weeks of pregnancy and subsequent fetal and infant development: a prospective population-based cohort study in China. J Clin Endocrinol Metabol. 2011;96(10):3234-41. DOI: https://doi.org/10.1210/jc.2011-0274

Vaidhya B, Anthony S, Bilous M, Shields B, Drury J, Hutchison S, Bilous R. Detection of Thyroid dysfunction in early pregnancy: Universal screening ot Targeted High risk case finding? J Clin Endocrinol Metab. 2007;92(1):203-7. DOI: https://doi.org/10.1210/jc.2006-1748

Goel P, Radotra A, Devi K, Malhotra S, Aggaewal A, Huria A. Maternal and perinatal outcome in pregnancy with hypothyroidism. Indian J Med Sci. 2005;59(3):116-7. DOI: https://doi.org/10.4103/0019-5359.15089

Stagnaro-Green A. Overt hyperthyroidism and Hypothyroidism during pregnancy. Clin Obstet Gynecol. 2011;54(3):478-87. DOI: https://doi.org/10.1097/GRF.0b013e3182272f32

Blazer S, Moreh-Waterman Y, Miller-Lotan R, Tamir A, Hochberg ZE. Maternal hypothyroidism may affect fetal growth and neonatal thyroid function. Obstetrics & Gynecology. 2003;102(2):232-41. DOI: https://doi.org/10.1097/00006250-200308000-00007

Wolfberg AJ, Lee-Parritz A, Peller AJ, Lieberman ES. Obstetric and neonatal outcomes associated with maternal hypothyroid disease. J Mat-Fetal Neonat Medi. 2005;17(1):35-9. DOI: https://doi.org/10.1080/14767050400028642

Canaris GJ, Manowitz NR, Mayor G, Ridgway EC. The Colorado thyroid disease prevalence study. Arch Intern Med. 2000;160(4):526-34. DOI: https://doi.org/10.1001/archinte.160.4.526

Cignini P, Cafà EV, Giorlandino C, Capriglione S, Spata A, Dugo N. Thyroid physiology and common diseases in pregnancy: review of literature. J Prenat Med. 2012;6(4):64-71.

Matalon S, Sheiner E, Levy A, Mazor M, Wiznitzer A. Relationship of treated maternal hypothyroidism and perinatal outcome. J Reprod Med. 2006;51(1):59-63.

Arojoki M, Jokimaa V, Juuti A, Koskinen P, Irjala K, Anttila L. Hypothyroidism among infertile women in Finland. Gynecol Endocrinol. 2000;14(2):127. DOI: https://doi.org/10.3109/09513590009167671

McLachlan SM, Rapoport B. The molecular biology of thyroid peroxidase: cloning, expression and role as autoantigen in autoimmune thyroid disease. Endocr Rev. 1992;13(2):192-206. DOI: https://doi.org/10.1210/edrv-13-2-192

Gene-NCBI. TG thyroglobulin [Homo sapians (human)]. Available at: https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=DetailsSearch&Term=7038. Accessed 16 September 2019.

Pratt DE, Kaberlein G, Dudkiewicz A, Karande V, Gleicher N. The association of antithyroid antibodies in euthyroid nonpregnant women with recurrent first trimester abortions in the next pregnancy. Fertil Steril. 1993;60(6):1001-5. DOI: https://doi.org/10.1016/S0015-0282(16)56400-0

Twig G, Shina A, Amital H, Shoenfeld Y. Pathogenesis of infertility and recurrent pregnancy loss in thyroid autoimmunity. J Autoimmun. 2012;38(2-3):J275-81. DOI: https://doi.org/10.1016/j.jaut.2011.11.014

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Published

2025-02-26

How to Cite

Selvam, S. S. P., Shivanna, M., Krishnegowda, R., & Rangaswamy, S. H. (2025). Fetomaternal outcome of newly detected thyroid disorders among pregnant women in tertiary care hospital: a cross sectional study. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 14(3), 797–802. https://doi.org/10.18203/2320-1770.ijrcog20250507

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Original Research Articles