A correlation study on testosterone level with luteinizing hormone to follicle stimulating hormone ratio among women with PCOS in reproductive age

Swetha Anil Kumar; Roshna V. K.; Pranav Kumar Prabhakar; Bineesh C. P.

doi:10.18203/2320-1770.ijrcog20243177

Authors

Swetha Anil Kumar Department of Biochemistry, Co-operative Institute of Health Sciences, Thalassery Kannur, Kerala, India
Roshna V. K. Department of Biochemistry, Co-operative Institute of Health Sciences, Thalassery Kannur, Kerala, India
Pranav Kumar Prabhakar Research and Development Cell, Parul University, Vadodara, Gujarat, India
Bineesh C. P. Department of Biochemistry, Co-operative Institute of Health Sciences, Thalassery Kannur, Kerala, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20243177

Keywords:

LH/FSH ratio, PCOS, Total testosterone

Abstract

ABSTRACT

Background: Polycystic ovarian syndrome (PCOS) is a female specific endocrinological condition. Traits of PCOS include menstrual irregularity, excess hair growth, elevated luteinizing hormone: follicle stimulating hormone (LH-FSH) ratio. The purpose of this study was to investigate any potential correlation between LH-FSH ratio and total testosterone levels in women with PCOS who were of reproductive age.

Methods: This cross-sectional study included 50 women with PCOS based on analysis of testosterone, luteinizing hormone, follicle stimulating hormone who have shown PCOS symptoms. The primary emphasis of this investigation was to testing blood samples for hormone levels (LH, FSH, total testosterone). Abott ARCHITECT Ci4100 was used to analyse the blood samples using chemiluminescent microparticle immunoassay (CMIA) chemiflex method.

Results: In this study 100 subjects between age 19-45 were taken; 50 were selected as tests and 50 were selected as controls. It has significantly showed a positive correlation with rising testosterone and LH/FSH ratio.

Conclusions: Among women with PCOS, the LH-FSH ratio was found to be substantially linked with total testosterone. This aid in a better understanding of the pathophysiology and management of hyperandrogenemia in PCOS women. PCOS cause irregularities of the menstrual cycle, the appearance of clinical manifestations, especially changes of LH/FSH ratio. This ratio can be used to support or confirm PCOS diagnosis along with other tests.

Metrics

Metrics Loading ...

References

Deshpande H. Polycystic ovarian syndrome (PCOS) a clinician’s manual. CBS Publishers; 2019:3-4.

Homburg R. Ovulation induction and controlled ovarian stimulation: a practical guide, 2nd edn. Springer Nature; 2014:5-6.

1. Deshpande H. Polycystic ovarian syndrome (PCOS) a clinician’s manual. CBS Publishers; 2019:33-35.

Dunaif A. Chang J, Franks S, Lergo RS. Polycystic Ovarian Syndrome Current controversies, from the ovary to the pancreas 1st edn. Springer; 2008:10-11.

Mitrašinović-Brulić M, Buljan M, Suljević D. Association of LH/FSH ratio with menstrual cycle regularity and clinical features of patients with polycystic ovary syndrome. Middle East Fertil Soc J. 2021;26:1-9.

Bansal K, Dimri PS, Reddy AP. Decoding polycystic ovarian syndrome (PCOS). Jaypee Brothers Medical Publishers (P) Ltd.; 2017:7-8.

Harris C, Cheung T. PCOS And your fertility: your guide to self care, emotional wellbeing and medical support. Hay House, Inc; 2011:15-16

Legro RS, Schlaff WD, Diamond MP, Coutifaris C, Casson PR, Brzyski RG, et al. Total testosterone assays in women with polycystic ovary syndrome: precision and correlation with hirsutism. J Clin Endocrinol Metab. 2010;95(12):5305-13.

Atoum MF, Alajlouni MM, Alzoughool F. A case-control study of the luteinizing hormone level in luteinizing hormone receptor gene (rs2293275) polymorphism in polycystic ovarian syndrome females. Public Health Genom. 2022;25(3-4):89-97.

Alnakash AH, Al-Tae e NK. Polycystic ovarian syndrome: the correlation between the LH/FSH ratio and disease manifestations. Middle East Fertil Soc J. 2007;12(1):35.

Mu L, Zhao Y, Li R, Lai Y, Qiao J. Metabolic characteristics of normal weight central obesity phenotype polycystic ovary syndrome women: a large-scale national epidemiological survey. Reproductive Biomed Online. 2018;37(4):498-504.

Deswal R, Narwal V, Dang A, Pundir CS. The prevalence of polycystic ovary syndrome: a brief systematic review. J Hum Reprod Sci. 2020;13(4):261-71.

Ye W, Xie T, Song Y, Zhou L. The role of androgen and its related signals in PCOS. J Cell Mol Med. 2021;25(4):1825-37.

Moran C, Garcia-Hernandez E, Barahona E, Gonzalez S, Bermudez JA. Relationship between insulin resistance and gonadotropin dissociation in obese and nonobese women with polycystic ovary syndrome. Fertil Steril. 2003;80(6):1466-72.

Hopkin K, Noursi S. Polycystic ovary/ ovarian syndrome (PCOS) Underrecognized, Underdiagnosed and Understudied. National Institute of Health; 2019: 3-5.

Xia Q, Xie L, Wu Q, Cong J, Ma H, Li J, et al. Elevated baseline LH/FSH ratio is associated with poor ovulatory response but better clinical pregnancy and live birth in Chinese women with PCOS after ovulation induction. Heliyon. 2023;9(1):1.

Beshyah SA, Bashir M, Ekhzaimy A. Diagnosis and management of polycystic ovary syndrome: a survey of physicians from the middle east and Africa. J Diabetes Endocr Pract. 2022;05(03):104-11.

Mitrašinović-Brulić M, Buljan M, Suljević D. Association of LH/FSH ratio with menstrual cycle regularity and clinical features of patients with polycystic ovary syndrome. Middle East Fertil Soc J. 2021;26:1-9.

Morshed MS, Banu H, Akhtar N, Sultana T, Begum A, Zamilla M, et al. Luteinizing hormone to follicle-stimulating hormone ratio significantly correlates with androgen level and manifestations are more frequent with hyperandrogenemia in women with polycystic ovary syndrome. J Endocrinol Metab. 2021;11(1):14-21.

Malini NA, George KR. Evaluation of different ranges of LH: FSH ratios in polycystic ovarian syndrome (PCOS)–Clinical based case control study. Gen Compar Endocrinol. 2018;260:51-7.

Saadia Z. Follicle stimulating hormone (LH:FSH) ratio in polycystic ovary syndrome (PCOS)- obese versus non-obese women. J Med Sci Bosnia Herzegovina. 2020;74(4):289-93.

Penttilä TA, Anttila L, Törmä A, Koskinen P, Erkkola R, Irjala K. Serum free testosterone in polycystic ovary syndrome measured with a new reference method. Fertil Steril. 1996;65(1):55-60.

Alnakash AH, Al-Tae e NK. Polycystic ovarian syndrome: the correlation between the LH/FSH ratio and disease manifestations. Middle East Fertil Soc J. 2007;12(1):35.

Fauser BCJM, Tarlatzis BC, Rebar RW, Legro RS, Balen AH, Lobo R, et al. Consensus on women’s health aspects of polycystic ovary syndrome (PCOS) Hum Reprod. 2012;27(1):14-24.

Lal L, Bharti A, Perween A. To study the status of LH: FSH ratio in obese and non-obese patients of polycystic ovarian syndrome. IOSR J Dent Med Sci. 2017;16(01):20-3.