Fetomaternal outcome in pregnant patients with Hepatitis-E infection
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20243179Keywords:
Hepatitis E, Maternal mortality, PregnancyAbstract
Background: Hepatitis E infection has been a major concern in pregnant women due to its fulminant nature in pregnancy compared to non-pregnant females and males. Hence the study was conducted for evaluating the maternal and perinatal outcome of pregnancy complicated by HEV infection.
Methods: A prospective observational cohort study was conducted in department of obstetrics and gynaecology Deen Dayal Upadhyay Hospital, New Delhi, from January 2020 to June 2020. Pregnant women of gestational age≥28weeks with jaundice and positive for IgM Anti-HEV were part of study (sample size 36).
Results: Hepatitis E virus infection adversely affects the maternal and fetal outcome with a maternal mortality of 11.1% noted in the study. Maternal complications observed were preterm labor (58.3%), PPROM (50.0%), PPH (47.2%), ICU admission (33.3%), fulminant hepatitis (11.1%), encephalopathy (11.1%). The common fetal complications noted were prematurity (47.2%), IUD (19.4%), NICU admission (47.2%).
Conclusions: The study shows that pregnant women with jaundice and acute viral hepatitis due to hepatitis E virus infection had a high mortality rate especially during third trimester and postpartum period. Also, they have poor obstetric and foetal outcome.
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References
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