First B-HCG predict pregnancy outcome after in-vitro fertilization

Authors

  • Sofia Andrade de Oliveira Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil http://orcid.org/0000-0002-6885-8295
  • Fernanda Silveira Seguro de Carvalho Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil
  • Julio Elito Júnior Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20170591

Keywords:

HCG - beta, In vitro fertilization, Pregnancy outcome

Abstract

Background: About 22% of IVF-conceived pregnancies result in spontaneous abortion. Therefore, it is important to predict the complicated and poor pregnancy outcome. Serum human chorionic gonadotrophin levels after 2 weeks of embryo transfer is a reliable marker to predict the pregnancy outcome in patients of IVF. Objective was to correlate the evolution curve of B-HCG after embryo transfer in assisted human reproduction techniques and the pregnancy outcome.

Methods: A prospective and observational study. In patients who underwent embryo transfer, a collection of quantitative B-HCG in 12th day after transfer was made. In patients who had beta-HCG positive value (beta-HCG>5.0 mUI/ml), there were two new collections of beta-HCG 48 hours and 72 hours after the first collection. All results have been filed and all pregnancies were accompanied to the final outcome.

Results: It was found that B-HCG values above 139.5 mIU / ml were associated with a good prognosis gestational.

Conclusions: Larger studies are needed to improve these findings and give better information regarding the prognostic value of early pregnancy hCG levels.

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References

Singh N, Goyal M, Malhotra N, Tiwari A, Badiger S. Predictive value of early serum beta‑human chorionic gonadotrophin for the successful outcome in women undergoing in vitro fertilization. J Hum Reprod Sci. 2013;6(4):245-7.

Lawler CC, Budrys NM, Rodgers AK, Holden A, Brzyski R, Schenken RS. Serum beta human chorionic gonadotropin levels can inform outcome counseling after in vitro fertilization. Fert Sterility. 2011;96(2):505-7.

Porat S, Savchev S, Bdolah Y, Hurwitz A, Haimov-Kochman R. Early serum human chorionic gonadotropin in pregnancies after in vitro fertilization: contribution of treatment variables and prediction of long-term pregnancy outcome. Fert Sterility. 2007;88(1):82-9.

Shamonki MI, Frattarelli JL, Bergh PA, Scott RT. Logarithmic curves depicting initial level and rise of serum beta human chorionic gonadotropin and live delivery outcomes with in vitro fertilization: An analysis of 6021 pregnancies. Fert Sterility. 2009;91(5):1760-4.

Anupama SQ, Kathiresan A, Cruz-Almeida Y, Barrionuevo MJ, Maxson WS, Hoffman DI, et al. Prognostic value of beta-human chorionic gonadotropin is dependent on day of embryo transfer during in vitro fertilization. Fert Sterility. 2011;96 (6):1362-6.

Fong SA, Rodriquez-Ayala H, Louis M, Howland R, McCulloh D, McGovern PG, et al. Early B-HCG levels predict pregnancy outcome. J Soc Gynecol Investig. 2005;12(2):226.

Barnhart K, Sammel MD, Chung K, Zhou L, Hummel AC, Guo W. Decline of serum human chorionic gonadotropin and spontaneous complete abortion: defining the normal curve. Obstet Gynecol. 2004;104:975-81.

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Published

2017-02-19

How to Cite

de Oliveira, S. A., Seguro de Carvalho, F. S., & Júnior, J. E. (2017). First B-HCG predict pregnancy outcome after in-vitro fertilization. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 6(3), 1093–1096. https://doi.org/10.18203/2320-1770.ijrcog20170591

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Original Research Articles