Pattern of high-risk human papilloma virus infection among women with cervical intraepithelial neoplasia
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20243592Keywords:
Cervical cancer, Cervical intraepithelial neoplasia, High-risk HPV, HPV infection, Women’s healthAbstract
Background: Cervical cancer ranks as the fourth most commonly diagnosed cancer and the fourth leading cause of cancer-related deaths in women. The purpose of this study was to assess the pattern of high-risk human papillomavirus (HPV) infection in women diagnosed with cervical intraepithelial neoplasia (CIN). The aim of the study was to evaluate the pattern of high-risk human papillomavirus (HPV) infection among women with cervical intraepithelial neoplasia (CIN).
Methods: This descriptive observational study involved 100 patients diagnosed with cervical intraepithelial neoplasia (CIN) at the gynecological oncology unit, department of gynecology and obstetrics, Dhaka Medical College Hospital, Dhaka, Bangladesh, from January 1, 2020, to December 31, 2020. Inclusion criteria comprised married women aged 30 to 60 years with colposcopically diagnosed CIN. Socio-demographic data, medical history, and clinical findings were collected and analyzed using SPSS 22.0.
Results: The mean age of the patients was 39.26 years (±6.99), with most being housewives (87%) and a large proportion residing in Dhaka (29%). HPV strains were detected in 67% of histopathologically diagnosed CIN cases, with HPV 16 being the most common strain, found in 67.34% of HPV-positive cases. Additionally, mono-infection was more prevalent than co-infection among HPV-positive patients (61.22% versus 38.8%), with the difference being statistically significant (p<0.05).
Conclusions: HPV genotypes 16 and 18, being the most prevalent in this study, highlight the need for targeted HPV vaccines and screening programs tailored to the Bangladeshi population to effectively prevent cervical cancer.
Metrics
References
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. ACS J. 2021;71(3):209-49.
Hoque MR, Haque E, Karim MR. Cervical cancer in low income countries: a Bangladeshi perspective. Int J Gynecol Obstet. 2020;152(1):19-25.
Anonymous. Human Papillomavirus and Related Cancers, Fact Sheet 2018. ICO Information Center on HPV and Cancer, Bangladesh. Accessed on 7 July 2019. Available from: file:///C:/Users/Hp/Downloads/hpvworld-090.pdf. Accessed on 25 September 2024.
Zhang L, Bi Q, Deng H, Xu J, Chen J, Zhang M, et al. Human papillomavirus infection among women with cervical lesions and cervical cancer in Eastern China: Genotype-specific prevalence and attribution. BMC Infect Dis. 2017;17:107.
Okunade KS. Human Papillomavirus and Cervical Cancer. In: Saxena SK, ed. Current Perspectives in Human Papillomavirus. 1st ed. London, UK: IntechOpen; 2019.
Clifford GM, Smith JS, Plummer M, Munoz N, Franceschi S. Human papillomavirus types in invasive cervical cancer worldwide: a meta-analysis. Br J Cancer. 2003;88:63-73.
Gallegos-Bolanos J, Rivera-Dominguez JA, Presno-Bernal JM, Cervantes-Villagrana RD. High prevalence of co-infection between human papillomavirus (HPV) 51 and 52 in Mexican population. BMC Cancer. 2017;17:531.
Senapati R, Nayak B, Kar SK, Dwibedi B. HPV genotype distribution in Indian women with and without cervical carcinoma: implication for HPV vaccination program in Odisha, Eastern India. BMC Infect Dis. 2017;17:30.
Akhter S, Manna P, Kamal M, Sung CJ, Lawrence WD, Quddus MR. Rare subtype(s) and frequency of multi-viral subtype high-risk human papilloma virus infection in high-grade squamous intraepithelial lesion and squamous cell carcinoma in a cervical carcinoma prevalent developing country: a multiplex real-time polymerase chain reaction-based pilot study. Diagn Pathol. 2016;11(1):92.
Chandona V, Gaguturu RB. Prevalence and determinants of high risk human papillomavirus in Hyderabad, India. Int J Reprod Contracept Obstet Gynecol. 2018;7(3):1012-8.
Xiao M, Xu Q, Li H, Gao H, Bie Y, Zhang Z. Prevalence of human papilloma virus genotype among women with high-grade cervical lesion in Beijing, China. Medicine. 2016;95:3.
So KyeongA SK, Lee InHo LI, Lee KiHeon LK, Hong SungRan HS, Kim YoungJun KY, Seo HyunHee SH, Kim TaeJin KT. Human papillomavirus genotype-specific risk in cervical carcinogenesis. J Gynecol Oncol. 2019;309(4).
Mane A, Nirmakar A, Risbud AR, Vermud SH, Mehendale SM, Sahasrabuddhe VV. HPV genotype distribution in cervical intraepithelial neoplasia among HIV-infected women in Pune, India. PLoS One. 2012;7(6).
Joarder M, Begum SA, Ahmed MR, Hossain MI, Islam S, Harun MA. Effect of human papillomavirus infection with pre-invasive cervical lesion: Bangladesh perspective. Bangladesh J Obstet Gynecol. 2018;33(1):5-10.
Robelo-Santos SH, Zeferino L, Villa LL, Sobrinho JP, Amaral RG, Magalhaes AV. Human papillomavirus prevalence among women with cervical intraepithelial neoplasia III and invasive cervical cancer from Goiania, Brazil. Mem Inst Oswaldo Cruz. 2003;98(2):1678-8060.
Wang W, An J, Song Y, Wang M, Huang M, Wu L. Distribution and attribution of high-risk human papillomavirus genotypes in cervical precancerous lesions in China. Tumor Biology. 2017 Jul;39(7):1010428317707373.
Zhang C, Huang C, Zhang X, Pan D. Prevalence of human papillomavirus among Wenzhou women diagnosed with cervical intraepithelial neoplasia and cervical cancer. Infect Agents Cancer. 2018;13:37.
Wang Z, Li Z, Li J, Wang C, Wang W, Hao M, et al. Prevalence and distribution of HPV genotypes in 1387 women with cervical intraepithelial neoplasia 2/3 in Shanxi Province, China. J Cancer. 2018;9(16):2802.
