Drotaverine hydrochloride and valethamate bromide action in management of labor
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20243599Keywords:
Antispasmodic, Cervical dilation, Drotaverine, Labor, Primigravida, Valethamate bromideAbstract
Background: Labor duration impacts maternal and perinatal morbidity. Antispasmodics like drotaverine hydrochloride and valethamate bromide are used to shorten labor by facilitating cervical dilation. This study compares the efficacy of these drugs in labor management.
Methods: A prospective study was conducted with 200 primigravida women in the active phase of labor. Participants were randomly divided into two groups: Group I received drotaverine hydrochloride (80 mg), and Group II received valethamate bromide (8 mg). Maternal and fetal outcomes, labor progression, and adverse effects were monitored.
Results: The mean cervical dilation rate for drotaverine was significantly higher (1.5570 cm/hr) compared to valethamate (1.0840 cm/hr). The first stage of labor was shorter in the drotaverine group (mean 187.200 min) than in the valethamate group (mean 279.850 min). No significant differences were observed in the second and third stages. Vaginal delivery rates were higher with drotaverine (81%) than with valethamate (69%). Tachycardia occurred in 3% of the valethamate group, while no adverse effects were noted with drotaverine.
Conclusions: Drotaverine hydrochloride accelerates cervical dilation and shortens labor more effectively than valethamate bromide, with no significant side effects on mother or fetus. It is a safer and more effective option for labor management.
Metrics
References
Prakash P. Rohtagi R. A Comparison of efficacy and side effects of drotaverine hydrochloride and valethamate bromide in augmentation of labour. Int J Health and Clinical Research. 2021;4(22):146-7.
Lowe NK. The nature of labor pain. American journal of obstetrics and gynecology. 2002;1;186(5):S16-24.
Bryant WM, Greenwell JE, Weeks PM. Alterations in collagen organization during dilatation of the cervix uteri. Surgery, Gynecology & Obstetrics. 1968;1;126(1):27-39.
Rao KB. Prolonged and obstructed labour. In:Arulkumaran S, Penna LK, Rao KB editors. The management of labour. 2nd edition, India: OrientLongman Private Ltd; 2005:340-9
Palii SB, Akkupalli VL, Maddi S. The Comparative Study of Drotaverine Hydrochloride and Valethamate Bromide in First Stage of Labor. J South Asian Fedaration Obstet Gynaecol. 2013;5(2):52-6.
Rohwer AC, Khondowe O, Young T. Antispasmodics for labour. Cochrane Database of Systematic Reviews. 2013(6):009243.
O'Driscoll KI, Foley M, MacDonald D. Active management of labor as an alternative to cesarean section for dystocia. Int J Repro Cont Obst Gyn. 1984;1;63(4):485-90.
Jayashree S, Ajjammanavar V, Sujatha MS. Comparison of drotaverine and valethamate bromide in first stage of labor. Int J Biol Med Res. 2013;4(2):3215-8.
Tile R, Jamkhandi S. To study the efficacy and safety of Drotaverine hydrochloride in augmentation of labour. Obs Rev J Obstet Gynecol. 2019;5(1):77-82.
Ahmad S, Rauf B, Shafiq A. Use of Spasfan in labour. J Himont Med. 2002;1:14-8.
Srivastava K, Sinha P, Sharma R, Gupta U. A comparative study of the effect of drotaverine hydrochloride with hyoscine butylbromide in first stage of labor. Int J Basic Clin Pharmacol. 2015;4(3):488-91.
Gitanjali B. Valethamate bromide. Is there any proof of efficacy and safety for its use in labor. J Pharmacol Pharmaco. 2010;1(1):2-3.
Sharma JB, Pundir P, Kumar A, Murthy NS. Drotaverine hydrochloride vs. valethamate bromide in acceleration of labor. Int J Repro Cont Obst Gyn. 2001;1;74(3):255-60.
Tripti N, Jyoti J. To compare and evaluate the efficacy and safety of drotaverine and valethamate bromide. J Obstet Gynecol. 2009;1;59(4):324-1.
Deshpande HG, Chilakalapalli HR, Shinde MJ, Choudhary S, Patel S, Saha S. Comparative efficacy of drotaverine hydrochloride valethamate bromide effects on cervical dilatation in active phase of labour in primigravida. EJMCM 2023;10:3239-3247.
Soni M, Gupta D, Godara S. Drotaverine hydrochloride versus valethamate bromide for cervical dilatation in labour: a comparative study. Int J Repro Cont Obst Gyn. 2020;1;9(5):1986-92.
Naga P, Shivanna BS, Subbappa K, Gopal N. Comparative study of efficacy of combination of valethamate bromide and hyoscine with drotaverine hydrochloride on cervical dilatation in active labor. IOSR-JDMS. 2014;13(10):27-9.
Kalhon P, Patil AB, Patel R. Efficacy of intramuscular Drotaverine use for cervical dilatation in first stage of labour. Int J Sci Tech. 2015;14(3):670-4.
Edessy M, EL-Darwish A, Nasr A, Ali A, El-Katatny H, Tammam M. Different modalities in first stage enhancement of labor. Gen Health Med Sci. 2015;2(1):1-4.
Patil AB, Kalhon P, Patel R. Comparative study of drotaverine hydrochloride and valethamate bromide in progress of labor. Inter J Recent Trends Sci Technol. 2015;14(3):678-82.
Shabanam, Verma R, Puja. Comparative study of drotaverine hydrochloride and valethamate bromide in management of labour. Int JAMP. 2023;5(3):1423-30.
Jogi SR. To compare the efficacy of Drotaverine Hydrochloride and Valethamate Bromide in shortening of the first stage of labour. International Int J Repro Cont Obst Gyn. 2015;1;4(4):1038-44.
Sinhasane H, Nishty GM. A comparative study on the efficacy of drotaverine and valethamate on cervical dilatation during labour. Int J Repro Cont Obst Gyn. 2017;1;6(2):423-7.
Mandal AK, Molla N. Comparison of efficacy of Drotaverine hydrochloride and Valethamate bromide in the augmentation of labour: a hospital based randomized trial. Int J Repro Cont Obst Gyn. 2018;1;7(4):1579-86.
Dahal P, Banerjee B, Uprety DK, Das BP, Thakur A, Agrawal A. Comparative study of efficacy of drotaverine hydrochloride and valethamate bromide with control in first stage of labour. Health Renaissance. 2013;10;11(1):38-42.
Pai MV, Sreekumar S, Gupta K, Chatterjee N. Effect of Drotaverine on active phase of labour. Obs and Gynae Today. 2003;8:611-4.
