Risk factor analysis of endometriosis in women of reproductive age: a tertiary care level hospital study in Bangladesh
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20250165Keywords:
Endometriosis, Risk factors, Reproductive age, Dysmenorrhea, Late childbearingAbstract
Background: Endometriosis is a disease in which tissue near the lining of the uterus grows outside the uterus. It can originate severe pain in the pelvis and make it harder to get pregnant. In several studies, several factors have been identified as the risk factors of endometriosis. But in Bangladesh, we have very limited research-based information regarding this issue. This study aimed to assess the risk factors of endometriosis in women of reproductive age.
Methods: This case-control study was conducted in the department of obstetrics and gynecology, Anwer Khan modern medical college, Dhaka, Bangladesh from January 2019 to December 2019. As per the inclusion criteria, in total 24 women of reproductive age with endometriosis were enrolled in the case group (Group 1). On the other hand, 24 age-matched women without endometriosis were enrolled in the control group (Group 2). A purposive sampling technique was used in sample selection. All the demographic and clinical data were analyzed by using the SPSS version 23.0 program and disseminated by the MS office program.
Results: In this study, assessing the risk factors of endometriosis among various reproductive histories of the participants revealed statistically significant correlations between the groups for the age of 30-40 years, late marriage, late childbearing, dysmenorrhea, and family history of endometriosis, with p values less than 0.05. However, when comparing genital tract obstruction, frequent and prolonged menstrual cycles, and nulliparity, we observed noticeable differences between the groups, but these were not statistically significant.
Conclusions: Age of 30-40 years, late marriage, late childbearing, dysmenorrhea, and family history of endometriosis may be considered the potential risk factors for endometriosis in women of reproductive age.
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References
Parazzini F, Esposito G, Tozzi L, Noli S, Bianchi S. Epidemiology of endometriosis and its comorbidities. Eur J Obstet Gynecol Reprod Biol. 2017;209:3-7. DOI: https://doi.org/10.1016/j.ejogrb.2016.04.021
Acién P, Velasco I. Endometriosis: a disease that remains enigmatic. ISRN Obstet Gynecol. 2013;2013:242149. DOI: https://doi.org/10.1155/2013/242149
Burney RO, Giudice LC. Pathogenesis and pathophysiology of endometriosis. Fertil Steril. 2012;98(3):511-9. DOI: https://doi.org/10.1016/j.fertnstert.2012.06.029
Giudice LC. Clinical practice. Endometriosis. N Engl J Med. 2010;362(25):2389-98. DOI: https://doi.org/10.1056/NEJMcp1000274
Dmowski WP, Lesniewicz R, Rana N, Pepping P, Noursalehi M. Changing trends in the diagnosis of endometriosis: a comparative study of women with pelvic endometriosis presenting with chronic pelvic pain or infertility. Fertil Steril. 1997;67(2):238-43. DOI: https://doi.org/10.1016/S0015-0282(97)81904-8
Sourial S, Tempest N, Hapangama DK. Theories on the pathogenesis of endometriosis. Int J Reprod Med. 2014;2014:179515. DOI: https://doi.org/10.1155/2014/179515
Nnoaham KE, Webster P, Kumbang J, Kennedy SH, Zondervan KT. Is early age at menarche a risk factor for endometriosis? a systematic review and meta-analysis of case-control studies. Fertil Steril. 2012;98(3):702-12.e6. DOI: https://doi.org/10.1016/j.fertnstert.2012.05.035
Meaddough EL, Olive DL, Gallup P, Perlin M, Kliman HJ. Sexual activity, orgasm and tampon use are associated with a decreased risk for endometriosis. Gynecol Obstet Invest. 2002;53(3):163-9. DOI: https://doi.org/10.1159/000058368
Hart R. Unexplained infertility, endometriosis and fibroids. BMJ. 2003;327:721-4. DOI: https://doi.org/10.1136/bmj.327.7417.721
Darwish AM, Hassanin MS, Abou Sekkin IA. Epidemiology and risk factors associated with laparoscopically diagnosed typical and atypical endometriosis among Egyptian women. Middle East Fertil Society J. 2006;11(3):196-201.
Gruppo Italiano per lo Studio dell’ endometriosi. Risk factors for pelvic endometriosis in women with pelvic pain or infertility. Eur J Obstet Gynecol Reprod Biol. 1999;83:195-9.
Berube S, Marcoux S, Maheux R. Characteristics related to the prevalence of minimal or mild endometriosis in infertile women. Canadian Collaborative Group on Endometriosis. Epidemiology. 1998;9(5):504-10. DOI: https://doi.org/10.1097/00001648-199809000-00006
Chaichian S, Mehdizadehkashi A, Najmi Z, Mobasseri A, Jahanloo A, Mohabbatian B, et al. Clinical Predictive Factors for Diagnosis of Endometriosis in Iranian Infertile Population. J Minim Invasive Surg Sci. 2015;4(3):1-4. DOI: https://doi.org/10.17795/minsurgery-24236
Moini A, Malekzadeh F, Amirchaghmaghi E, Kashfi F, Akhoond MR, Saei M, et al. Risk factors associated with endometriosis among infertile Iranian women, Arch Med Sci. 2013;9(3):506-14. DOI: https://doi.org/10.5114/aoms.2013.35420
Missmer SA, Hankinson SE, Spiegelman D, Barbieri RL, Marshall LM, Hunter DJ. Incidence of laparoscopically confirmed endometriosis by demographic, anthropometric, and lifestyle factors. Am J Epidemiol. 2004;160:784-96. DOI: https://doi.org/10.1093/aje/kwh275
Matalliotakis IM, Cakmak H, Fragouli YG, Goumenou AG, Mahutte NG, Arici A. Epidemiological characteristics in women with and without endometriosis in the Yale series. Arch Gynecol Obstet. 2008;277:389-93. DOI: https://doi.org/10.1007/s00404-007-0479-1
Ashrafi M, Jahanian Sadatmahalleh S, Akhoond MR, Talebi M. Evaluation of risk factors associated with endometriosis in infertile women. Int J Fertil Steril. 2016;10(1):11-21.