Association of preoperative systemic inflammation score with clinicopathological feature in the early stage of carcinoma cervix

Syfun Naher; Shirin Akter Begum; Naznine Akter; Farhana Khatoon; Fatema Nihar; Subrina Meher; Fahmida Sultana; Mofazzal Hossen

doi:10.18203/2320-1770.ijrcog20243925

Authors

Syfun Naher Department of Obstetrics and Gynecology, Directorate General of Health Services (DGHS), Dhaka, Bangladesh
Shirin Akter Begum Department of Gynecological Oncology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh
Naznine Akter Department of Obstetrics and Gynecology, Institute of Health Technology, Dhaka, Bangladesh
Farhana Khatoon Department of Gynecological Oncology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh
Fatema Nihar Department of Gynecological Oncology, National Institute of Cancer and Research Hospital (NICRH), Dhaka, Bangladesh
Subrina Meher Department of Obstetrics and Gynecology, Directorate General of Health Services (DGHS), Dhaka, Bangladesh
Fahmida Sultana Department of Obstetrics and Gynecology, Sheikh Sayera Khatun Medical College (SSKMC), Gopalganj, Bangladesh
Mofazzal Hossen Department of Mathematics, Azimpur Government Girls School and College, Dhaka, Bangladesh

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20243925

Keywords:

Clinicopathological feature, Early-stage carcinoma cervix, Systemic inflammation score

Abstract

Background: Cervical cancer is a significant global health concern, particularly in its early stages (stage IA-IIA). Systemic inflammation’s influence on cancer has been explored extensively in other tumor types, its association with clinicopathological features in early-stage carcinoma of the cervix remains a relatively underexplored area. This study aimed to evaluate the association of preoperative systemic inflammation score with clinicopathological features in the early stage of carcinoma cervix.

Methods: This was a cross-sectional study that was carried out in the department of gynecological oncology at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh during the period from June 2022 and July 2023. In our study, we included 90 cervical cancer stage IA-IIA patients who underwent primary radical hysterectomy with bilateral pelvic lymphadenectomy.

Results: Among all study participants, the mean age was 45.1±9.03 years. Majorities (65.6%) were found taking oral contraceptive pills. Higher SIS scores were strongly associated with larger tumor sizes, with mean tumor sizes of 1.45 cm (SIS 0), 1.99 cm (SIS 1), and 2.54 cm (SIS 2), respectively. Additionally, the incidence of lymphovascular space invasion (LVSI) demonstrated a pronounced increase with higher SIS scores, with 7.7% (SIS 0) and 92.3% (SIS 1-2) exhibiting LVSI. These associations were statistically significant (p<0.05).

Conclusions: The study findings conclude that there is an association of pretreatment systemic inflammation score SIS with tumor size, lymphovascular space invasion, and increased depth of stromal invasion. SIS preoperatively can predict the clinicopathological risk factor of cancer cervix.

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