Large uterine leiomyoma with smooth muscle tumour of uncertain malignant potential: a case report
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20250541Keywords:
STUMP, Smooth muscle tumour of uncertain malignant potential, Uterine neoplasm, Fibroid, MyomectomyAbstract
Smooth muscle tumours of uncertain malignant potential (STUMP) are a category of uterine neoplasms that do not meet the criteria for benign or malignant tumours, potentially representing an intermediate stage between leiomyomas and leiomyosarcomas. A 26-year-old nulliparous woman presented with heavy menstrual bleeding and an abdominal mass, with preoperative imaging suggesting a benign uterine myoma. Following a laparoscopic myomectomy, histological analysis revealed STUMP, characterized by a low mitotic index and marked nuclear pleomorphism without necrosis. The patient was advised to conceive soon and plan for definitive surgery after completing her family. She later delivered via elective caesarean section at 35 weeks and is currently recovering well. STUMP often mimics benign leiomyomas and is usually diagnosed post-surgery, complicating preoperative assessment. Recurrence rates vary, particularly in younger patients, emphasizing the need for individualized management strategies that balance fertility preservation with monitoring for recurrence. Regular follow-ups are essential for optimal care.
Metrics
References
Dall'Asta A, Gizzo S, Musarò A, Quaranta M, Noventa M, Migliavacca C, et al. Uterine smooth muscle tumors of uncertain malignant potential (STUMP): pathology, follow-up and recurrence. Int J Clin Exp Pathol. 2014;7(11):8136-42.
Picerno TM, Wasson MN, Gonzalez Rios AR, Zuber MJ, Taylor NP, Hoffman MK, et al. Morcellation and the Incidence of Occult Uterine Malignancy: A Dual-Institution Review. Int J Gynecol Cancer. 2016;26(1):149-55. DOI: https://doi.org/10.1097/IGC.0000000000000558
Stewart EA, Quade BJ, Laughlin-Tommaso SK. Variants of uterine leimyomas (fibroids). 2017. UpToDate. Available at: http://www.uptodate.com. Accessed on 12 October 2024.
Ip PP, Tse KY, Tam KF. Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy. Adv Anat Pathol. 2010;17(2):91-112. DOI: https://doi.org/10.1097/PAP.0b013e3181cfb901
Vilos GA, Marks J, Ettler HC, Vilos AG, Prefontaine M, Abu-Rafea B. Uterine smooth muscle tumors of uncertain malignant potential: diagnostic challenges and therapeutic dilemmas. Report of 2 cases and review of the literature. J Minim Invasive Gynecol. 2012;19(3):288-95. DOI: https://doi.org/10.1016/j.jmig.2011.12.025
Guntupalli SR, Ramirez PT, Anderson ML, Milam MR, Bodurka DC, Malpica A. Uterine smooth muscle tumor of uncertain malignant potential: a retrospective analysis. Gynecol Oncol. 2009;113(3):324-6. DOI: https://doi.org/10.1016/j.ygyno.2009.02.020
Schwartz LB, Zawin M, Carcangiu ML, Lange R, McCarthy S. Does pelvic magnetic resonance imaging differentiate among the histologic subtypes of uterine leiomyomata? Fertil Steril. 1998;70(3):580-7. DOI: https://doi.org/10.1016/S0015-0282(98)00193-9
Benson C, Miah AB. Uterine sarcoma - current perspectives. Int J Womens Health. 2017;9:597-606. DOI: https://doi.org/10.2147/IJWH.S117754
Skorstad M, Kent A, Lieng M. Preoperative evaluation in women with uterine leiomyosarcoma. A nationwide cohort study. Acta Obstet Gynecol Scand. 2016;95(11):1228-34. DOI: https://doi.org/10.1111/aogs.13008
Bell SW, Kempson RL, Hendrickson MR. Problematic uterine smooth muscle neoplasms. A clinicopathologic study of 213 cases. Am J Surg Pathol. 1994;18(6):535-58. DOI: https://doi.org/10.1097/00000478-199406000-00001
Ip PP, Cheung AN, Clement PB. Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases. Am J Surg Pathol. 2009;33(7):992-1005. DOI: https://doi.org/10.1097/PAS.0b013e3181a02d1c
Atkins KA, Arronte N, Darus CJ, Rice LW. The Use of p16 in enhancing the histologic classification of uterine smooth muscle tumors. Am J Surg Pathol. 2008;32(1):98-102. DOI: https://doi.org/10.1097/PAS.0b013e3181574d1e
Macciò A, Chiappe G, Kotsonis P, Lavra F, Serra M, Demontis R, et al. Abdominal leiomyosarcomatosis after surgery with external morcellation for occult smooth muscle tumors of uncertain malignant potential: A case report. Int J Surg Case Rep. 2017;38:107-10. DOI: https://doi.org/10.1016/j.ijscr.2017.07.020
Campbell JE, Knudtson JF, Valente PT, Robinson RD, Kost ER. Successful pregnancy following myomectomy for uterine smooth muscle tumor of uncertain malignant potential: A case report and review of the literature. Gynecol Oncol Rep. 2015;15:1-3. DOI: https://doi.org/10.1016/j.gore.2015.07.005
Amant F, Moerman P, Vergote I. Report of an unusual problematic uterine smooth muscle neoplasm, emphasizing the prognostic importance of coagulative tumor cell necrosis. Int J Gynecol Cancer. 2005;15(6):1210-2. DOI: https://doi.org/10.1111/j.1525-1438.2005.00183.x