Challenges in cyto-diagnosis: a report of 2 interesting cases of pseudomyxoma peritonei

Gauri U. Kale; Shital P. Mahure; Dharitri M. Bhat; Satish B. Helwatkar

doi:10.18203/2320-1770.ijrcog20250544

Authors

Gauri U. Kale Department of Pathology, Government Medical College and Hospital, Nagpur, Maharashtra, India
Shital P. Mahure Department of Pathology, Government Medical College and Hospital, Nagpur, Maharashtra, India
Dharitri M. Bhat Department of Pathology, Government Medical College and Hospital, Nagpur, Maharashtra, India
Satish B. Helwatkar Department of Pathology, Government Medical College and Hospital, Nagpur, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20250544

Keywords:

Pseudomyxoma peritonei, Immunohistochemistry, Gastro-intestinal tract, Cytokeratin

Abstract

Diffuse intra-abdominal gelatinous or mucinous ascites is commonly known as pseudomyxoma peritonei (PMP). It is a clinical entity rather than a histological diagnosis and usually results from peritoneal dissemination of mucus producing neoplasms most frequently from the appendix and rarely other GIT tumours. Since ascites may be the first symptom, cytologists may face diagnostic challenges in mucinous ascites. We present two cases of mucinous ascites in elderly females, in which thick, sticky, gelatinous fluid was received for cytological examination. After correlation of cytological examination findings with clinical and radiological features, diagnosis of disseminated peritoneal adenomucinosis was made which was later confirmed by fluid cell block with IHC studies.

Metrics

Metrics Loading ...

References

Khape N. A case study on jelly belly: Pseudomyxoma peritonei. Indian J Continuing Nursing Educat. 2023;24(1):11-5. DOI: https://doi.org/10.4103/ijcn.ijcn_107_22

Govaerts K, Lurvink RJ, De Hingh IH, Van der Speeten K, Villeneuve L, Kusamura S, et al. Appendiceal tumours and pseudomyxoma peritonei: literature review with PSOGI/EURACAN clinical practice guidelines for diagnosis and treatment. Europ J Surgical Oncol. 2021;47(1):11-35. DOI: https://doi.org/10.1016/j.ejso.2020.02.012

Shin HJ, Sneige N. Epithelial cells and other cytologic features of pseudomyxoma peritonei in patients with ovarian and/or appendiceal mucinous neoplasms: A study of 12 patients including 5 men. Cancer Cytopathology. 2000;90(1):17-23. DOI: https://doi.org/10.1002/(SICI)1097-0142(20000225)90:1<17::AID-CNCR3>3.0.CO;2-D

Kurman RJ, editor. Blaustein's pathology of the female genital tract. Springer Science and Business Media. 2013.

Nagtegaal ID, Odze RD, Klimstra D, Paradis V, Rugge M, Schirmacher P, et al. The 2019 WHO classification of tumours of the digestive system. Histopathology. 2020;76(2):182. DOI: https://doi.org/10.1111/his.13975

Rekhtman N, Bishop JA. Quick reference handbook for surgical pathologists. Berlin: Springer. 2011. DOI: https://doi.org/10.1007/978-3-642-20086-1

Shinde S, Sawant SA. Low grade appendiceal mucinous neoplasm. Indian J Pathol Oncol. 2022;9(1):81-3. DOI: https://doi.org/10.18231/j.ijpo.2022.019