A case of Dili-drug induced liver injury by norethisterone combined with mifepristone

Abstract

DILI related to female sex hormones like estrogen and progesterone generally occur with estrogen component. Progesterone related DILI are not commonly reported. We are reporting a case of DILI by norethisterone combined with mifepristone in a 37-year-old woman. Oral contraceptives have been shown to be associated with variety of liver injuries. Various manifestations include hepatitis, cholestatisis, hepatic adenoma, peliosis hepatitis, sinusoidal obstruction syndrome and increase in size of pre-existing hemangiomas. It is important to create awareness about norethisterone-induced liver injury among clinicians, especially gynaecologists and also use combination drugs after studying the mechanism of action, agonistic and antagonistic actions.