Misoprostol versus Dinoprostone for induction of labour in premature rupture of membranes

Rachana R. S.; V. B. Bangal

doi:10.18203/2320-1770.ijrcog20250501

Authors

Rachana R. S. Department of Obstetrics & Gynaecology, Dr. BVP Rural Medical College, Loni, Ahmednagar, Maharashtra, India
V. B. Bangal Department of Obstetrics & Gynaecology, Dr. BVP Rural Medical College, Loni, Ahmednagar, Maharashtra, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20250501

Keywords:

Labour, Misoprostol, Dinoprostone

Abstract

Background: To compare the efficacy of misoprostol (PG E1 analog) and Dinoprostone (PGE2) for induction of labour in patients with premature rupture of membranes (PROM).

Methods: This prospective study was conducted at the Department of Obstetrics and Gynaecology, Dr. BVP Rural medical college, Loni, Ahmednagar, Maharashtra. A total of 120 women (60 in each group) presenting with PROM (premature rupture of membranes) within 48 hours with gestational age between 34 weeks to 40 weeks were included. Group A women received tab misoprostol 25 mcg orally and Group B women received Dinoprostone gel vaginally kept in posterior vaginal fornix for induction of labour. Dose was repeated every 4th hourly in Group A with maximum of 4 doses and it was repeated 6th hourly In Group B with maximum of 3 doses.

Results: Among 60 patients in Group A, 47 (78.33%) delivered vaginally and 13 (21.66%) were delivered by caesarean section. In Group B, 39(65%) patients delivered vaginally and 21(35%) were delivered by LSCS.

Conclusions: Oral misoprostol 25 mcg 4 hourly is efficient and cost-effective alternative to PGE2 gel for cervical ripening and induction of labour in PROM patients.

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