Clinical usefulness of hysterolaparoscopy and chromopertubation in evaluation and management of female infertility in a tertiary care hospital

Authors

  • Sampada N. S. Department of Obstetrics and Gynecology, Sapthagiri Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India
  • Madhuri Saha Department of Obstetrics and Gynecology, Sapthagiri Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India
  • Rajini Uday Department of Obstetrics and Gynecology, Sapthagiri Institute of Medical Sciences and Research Centre, Bangalore, Karnataka, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20250862

Keywords:

Infertility, Hysterolaparoscopy, Chromopertubation

Abstract

Background: Infertility is defined by the World Health Organization (WHO) as the inability to achieve pregnancy after 12 months of unprotected intercourse which affects 10–15% of couples globally. In India, prevalence ranges from 3.9% to 16.8%. Hysterolaparoscopy combined with chromopertubation (DHL + CPT) serves as a valuable diagnostic and therapeutic tool in case of female infertility. This study evaluates the effectiveness of DHL + CPT in managing primary and secondary infertility at a tertiary care hospital.

Methods: In this prospective study, 60 women with primary or secondary infertility underwent clinical evaluations, basic blood tests, and abdominopelvic ultrasonography during the study period. Participants underwent DHL + CPT during their preovulatory phase following a negative urine pregnancy test. Tubal patency was assessed using methylene blue dye, and therapeutic interventions like cystectomy, adhesiolysis, ovarian drilling, septal resection were performed as necessary. Reproductive outcomes were monitored through follow-up visits or telephone correspondence.

Results: Among the participants, 75% had primary infertility, and 25% had secondary infertility. Of the 32 primary infertility patients followed up, 24 (75%) conceived within six months. In the secondary infertility group, 10 out of 18 patients (55.5%) achieved pregnancy within six months. Therapeutic interventions were performed in 53% of cases, yielding promising reproductive outcomes.

Conclusions: DHL + CPT is an effective, cost-efficient, and accessible method for evaluating and managing reversible causes of infertility. Patients undergoing interventions demonstrated significant improvements in fertility outcomes. However further research is warranted to explore newer, less invasive, and more cost-effective interventions.

Metrics

Metrics Loading ...

References

Vander Borght M, Wyns C. Fertility and infertility: Definition and epidemiology. Clin Biochem. 2018;62:2-10. DOI: https://doi.org/10.1016/j.clinbiochem.2018.03.012

Boivin J, Bunting L, Collins JA, Nygren KG. International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. Hum Reprod. 2007;22(6):1506-12. DOI: https://doi.org/10.1093/humrep/dem046

Chanu SM, Rudra Pal GS, Panda S, Santa Singh AS. Diagnostic Hysterolaparoscopy for Evaluation of Infertility: Our Experience in a Tertiary Care Hospital. J Hum Reprod Sci. 2018;11(1):19-23.

Puri S, Jain D, Puri S, Kaushal S, Deol SK. Laparohysteroscopy in female infertility: A diagnostic cum therapeutic tool in Indian setting. Int J Appl Basic Med Res. 2015;5(1):46-8.

Grigovich M, Kacharia VS, Bharwani N, Hemingway A, Mijatovic V, Rodgers SK. Evaluating Fallopian Tube Patency: What the Radiologist Needs to Know. Radiographics. 2021;41(6):1876-961. DOI: https://doi.org/10.1148/rg.2021210033

Al-Turki HA. Prevalence of primary and secondary infertility from a tertiary center in eastern Saudi Arabia. Middle East Fertil Soc J. 2015;20(4):237-41. DOI: https://doi.org/10.1016/j.mefs.2015.02.001

Sharma P, Jhanwar A, Kumari K, Arya J, Bharti B, Majeed B, Dabas D. A Prospective Study to Evaluate the Role of Combined Diagnostic Laparoscopy and Hysteroscopy in the Management of Female Infertility. Cureus. 2024;16(1):e52170. DOI: https://doi.org/10.7759/cureus.52170

Godinjak Z, Idrizbegović E. Should diagnostic hysteroscopy be a routine procedure during diagnostic laparoscopy in infertile women? Bosn J Basic Med Sci. 2008;8(1):44-7. DOI: https://doi.org/10.17305/bjbms.2008.2996

Shrivastava M, Meena BS. Study of Role of Combined Diagnostic Hysteroscopy and Laparoscopy in Evaluating Factors for Infertility. J Med Sci Clin Res. 2019;7(1):803-7. DOI: https://doi.org/10.18535/jmscr/v7i1.140

Gad A, Abdallah K, Emam S. Role of hysteroscopy and laparoscopy in evaluation of unexplained infertility. Menoufia Med J. 2019;32(4):45. DOI: https://doi.org/10.4103/mmj.mmj_387_18

Pabuçcu R, Gomel V. Reproductive outcome after hysteroscopic metroplasty in women with septate uterus and otherwise unexplained infertility. Fertil Steril. 2014;81(6). DOI: https://doi.org/10.1016/j.fertnstert.2003.10.035

Pritts EA, Parker WH, Olive DL. Fibroids and infertility: an updated systematic review of the evidence. Fertil Steril. 2009;91(4):1215-23. DOI: https://doi.org/10.1016/j.fertnstert.2008.01.051

Deol S, Puri S, Kaur H. Laparohysteroscopy in female infertility: A diagnostic cum therapeutic tool in Indian setting. Int J Appl Basic Med Res. 2015;5(1):46-8. DOI: https://doi.org/10.4103/2229-516X.149240

Varlas VN, Tsikouras P, Bothou A. Correlation between hysterosalpingography diagnosis and final laparoscopic diagnosis of tubal pathology in infertile women: A systematic review. J Obstet Gynaecol Res. 2021;47(3):973-81.

Chanu SM, Rudra Pal GS, Panda S, Santa Singh AS. Diagnostic Hysterolaparoscopy for Evaluation of Infertility: Our Experience in a Tertiary Care Hospital. J Hum Reprod Sci. 2018;11(1):19-23. DOI: https://doi.org/10.4103/jhrs.JHRS_114_16

Akazawa M, Wu YH, Liu WM. Allergy-like reactions to methylene blue following laparoscopic chromopertubation: A systematic review of the literature. Eur J Obstet Gynecol Reprod Biol. 2019;238:58-62. DOI: https://doi.org/10.1016/j.ejogrb.2019.03.019

Ramesh B, Kurkuri SN. Role of combined hystero-laparoscopy in the evaluation of female infertility as one step procedure: a retrospective analytical study of 250 patients. Int J Reprod Contracept Obstet Gynecol. 2016;5(2):396-401. DOI: https://doi.org/10.18203/2320-1770.ijrcog20160377

Downloads

Published

2025-03-27

How to Cite

N. S., S., Saha, M., & Uday, R. (2025). Clinical usefulness of hysterolaparoscopy and chromopertubation in evaluation and management of female infertility in a tertiary care hospital. International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 14(4), 1200–1205. https://doi.org/10.18203/2320-1770.ijrcog20250862

Issue

Section

Original Research Articles