A prospective study on possible clinical correlation between peripartum cardiomyopathy and hypertensive disorder in pregnancy
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20251243Keywords:
Peripartum, Cardiomyopathy, Hypertensive disorder in pregnancy, Left ventricle ejection fractionAbstract
Background: Peripartum cardiomyopathy (PPCM) and hypertensive disorder in pregnancy (HDP) are often seen together. Though their correlation is a matter of research.
Methods: A prospective study of 76 patients of HDP in Apollo hospital Bilaspur (C. G.) over a period of one year February 2024 to February 2025 correlation with echocardiography.
Results: The maximum number of people with compromised left ventricular ejection fraction (LVEF) function is 28 years. Similarly in our study most of the patients are multigravida which is 22.37%. Maximum patients are of 3rd gravida.
Conclusions: Although the majority of HDP women were having normal LVEF function with no signs of PPCM but HDP was associated with markedly increased risks of PPCM that increased with HDP severity. HDP in association with increasing parity and age is also one of the contributing risk factors for PPCM. HDP, severe preeclampsia in particular, probably represents an additional cardiac stress during pregnancy.
Metrics
References
Williams Obstetrics
Pearson GD, Ville JC, Rahimtoola S, Hsia J, Oakley CM, Hosenpud JD, et al. Peripartum Cardiomyopathy: National heart, lung and blood institute and office of rare diseases (National institute of health) workshop, recommendation and review. JAMA. 2000;283(9):1183-8. DOI: https://doi.org/10.1001/jama.283.9.1183
Sliwa K, Hilfiker-Kleiner D, Petrie MC, Mebazaa A, Pieske B, Buchmann E, et al. Heart Failure Association of the European Society of Cardiology Working Groupon Peripartum Cardiomyopathy Current state of knowledge onaetiology, diagnosis, management, and therapy of peripartum car-diomyopathy: a position statement from the heart failureAssociation of the European Society of cardiology working groupon peripartum cardiomyopathy. Eur J Heart Fail. 2010;12(8):767-78. DOI: https://doi.org/10.1093/eurjhf/hfq120
American College of O, Gynecologists, Task Force onHypertension in P. Hypertension in pregnancy. Report of theAmerican College of Obstetricians and Gynecologists’Ta skForce on Hypertension in Pregnancy. Obstet Gynecol. 2013;122(5):1122-31.
Shahul S, Medvedofsky D, Wenger JB, Nizamuddin J, Brown SM, Bajracharya S, et al. Circulating antiangiogenic factors and myo-cardial dysfunction in hypertensive disorders of pregnancy. Hypertension. 2016;67(6):1273-80. DOI: https://doi.org/10.1161/HYPERTENSIONAHA.116.07252
Mebazaa A, Seronde MF, Gayat E, Tibazarwa K, Anumba DOC, Akrout N, et al. Imbalanced angiogenesis in peripartum cardiomy-opathy-diagnostic value of placenta growth factor. Circ J. 2017;81(11):1654-61. DOI: https://doi.org/10.1253/circj.CJ-16-1193
Damp J, Givertz MM, Semigran M, Alharethi R, Ewald G, Felker GM, et al. Relaxin-2 and soluble Flt1 levels in peripartum cardio-myopathy: results of the multicenter IPAC study. JACC Heart Fail. 2016;4(5):380-8. DOI: https://doi.org/10.1016/j.jchf.2016.01.004
Ntusi NB, Badri M, Gumendze F, Karen S, Bongani MM. Pregnancy associated heart failure: a comparison of clinical presentation and Outcome between hypertensive heart failure of pregnancy and idiopathic peripartum cardiomyopathy. PLoS One. 2015;10(8):e0133466. DOI: https://doi.org/10.1371/journal.pone.0133466
Behrens I, Basit S, Lykke JA, Ranthe MF, Wohlfahrt J, Bundgaard H, et al. Hypertensive disorders of pregnancy and peripartum cardiomyopathy: A nationwide cohort study. PLoS One. 2019;14(2):e0211857. DOI: https://doi.org/10.1371/journal.pone.0211857