Virilizing Leydig cell tumor of the ovary: from presentation to treatment - a case report
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20251600Keywords:
Virilization, Leydig cell tumor, Androgen-secreting ovarian tumor, Hirsutism, Sex cord-stromal tumorAbstract
Leydig cell ovarian tumor is a rare sex cord-gonadal stromal tumor which constitutes less than 0.2% of ovarian tumors. As they produce testosterone, virilization is the most common presenting feature. This case report discusses a multiparous, 55 years old, postmenopausal lady who presented with complaints of excessive scalp hair loss and increased facial hair growth since two years. On examination she had androgenic alopecia, increased facial and midline body hair and clitoromegaly. Blood investigations done showed elevated S. testosterone. CT abdomen done showed no pathological lesions in the adrenal glands. MRI done in view of suspicion of Androgen secreting ovarian tumour showed mildly enlarged left ovary measuring 2×1.8 cm with altered signal intensity. She underwent total laparoscopic hysterectomy with bilateral salpingo-oophorectomy. Post operatively, histopathological examination was reported as Benign Leydig cell tumour of left ovary.
Metrics
References
Nelson AT, Harris AK, Watson D, Kamihara J, Chen KS, Stall JN, et al. Outcomes in ovarian SertoliLeydig cell tumor: A report of the International Ovarian and Testicular Stromal Tumor Registry. Gynecol Oncol. 2024;164(2):392-8.
Demidov VN, Lipatenkova J, Vikhareva O, Holsbeke CV, Timmerman D, Valentin L. Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli-Leydig cell tumors and Leydig cell tumors. Ultrasound Obstet Gynecol. 2008;31(1):85-91. DOI: https://doi.org/10.1002/uog.5227
Deavers MT, Malpica A, Ordonez NG, Silva EG. Ovarian Leydig cell tumor: a clinicopathologic study of 23 cases. Am J Surg Pathol. 1999;23(10):1203-11.
Fanta M, Fischerová D, Indrielle-Kelly T, Koliba P, Zdeňková A, Burgetová A, et al. Diagnostic pitfalls in ovarian androgensecreting (Leydig cell) tumours: case series. J Obstet Gynaecol. 2019;39(3):359-64. DOI: https://doi.org/10.1080/01443615.2018.1517148
Gennari P, Scaffa C, Ceruti P, Sorrenti G, Scaglione M, Ferrero S, et al. "Occult" ovarian Leydig cell tumor: when laboratory tells more than imaging. Gynecol Endocrinol. 2014;30(3):213-6.
Gadducci A, Zannoni GF. Sertoli-Leydig cell tumors of the ovary: a therapeutic challenge for gynecologic oncologists. Gynecol Oncol. 2021;161(2):471-9.
Zanagnolo V, Pasinetti B, Sartori E. Ovarian Sertoli-Leydig cell tumors: a retrospective study of 63 cases. Gynecol Oncol. 2004;93(2):379-84.