Risk factors for recurrence of invasive breast cancer after primary surgery in patients followed at the medical oncology and palliative care department of Soavinandriana Hospital Center
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20251949Keywords:
Breast, Cancer, Invasive, Recurrence, SurgeryAbstract
Background: Breast cancer mortality is often linked to recurrence or progression. This study aims to identify and describe the risk factors for recurrence in invasive breast cancers after primary surgery.
Methods: A case-control study was conducted from January 1, 2017, to December 31, 2023.
Results: The study included 55 cases and 55 controls. Identified risk factors for recurrence include age under 50 (OR 3.21; p=0.005), partial mastectomy (OR 7.7; p=0.001), vascular emboli or perineural invasion (OR 2.85; p=0.019), poor resection margin (R+) (OR 16.36; p=0.00), >25% lymph node invasion (OR 5.33; p=0.002), capsular rupture (OR 8.78; p=0.000), CA 15-3 >30 U/ml (OR 6.66; p=0.01), and lack of radiotherapy (OR 3.39; p=0.002) or chemotherapy (OR 4.07; p=0.001) as adjuvant treatments.
Conclusions: The identified risk factors align with those in existing literature and should be considered to enhance breast cancer treatment.
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References
Haute Autorité de Santé (HAS), Institut National du Cancer (INCa). La prise en charge du cancer du sein, guide patient-affection de longue durée. 2010. Disponible sur. Available at: https://www.has-sante.fr/jcms/p_3261756/fr/cancer-du-sein. Accessed on 8 June 2023.
Deo SVS, Sharma J, Kumar S. GLOBOCAN 2020 Report on Global Cancer Burden: Challenges and Opportunities for Surgical Oncologists. Ann Surg Oncol. 2022;29(11):6497 500. DOI: https://doi.org/10.1245/s10434-022-12151-6
Geffroy-Bellan M. Traitement chirurgical des récidives mammaires après traitement conservateur initial du cancer du sein. Y a-t-il une place pour un second traitement conservateur ? 2010. Disponible sur. Available at: https://hal.univ-lorraine.fr/hal-01734148. Accessed on 8 June 2023.
Nour al Islam B, Nourhane B. Étude épidémiologique sur le cancer du sein en Algérie. Département Science de la Nature et de la Vie, Université Dr Yahia Fares; 2021-2022;159.
Sancho-Garnier H, Colonna M. Épidémiologie des cancers du sein. Presse Med. 2019;48:1076-84. DOI: https://doi.org/10.1016/j.lpm.2019.09.022
Rafaramino F, Rakotobe P, Pignon T. Prise en charge du cancer du sein à Madagascar. Cancer Radiother. 2001;5(4):445. DOI: https://doi.org/10.1016/S1278-3218(01)00115-9
Ranaivomanana M, Hasiniatsy NR, Rakotomahenina H, Rafaramino F. Aspects épidémio-cliniques des cancers du sein au Service d´ Oncologie de Fianarantsoa, Madagascar de 2011 à 2018. Pan African Med J. 2021;38(1). DOI: https://doi.org/10.11604/pamj.2021.38.264.20031
Ranaivomanana M, Hasiniatsy NRE, Rabarikoto HF, Randriamahaonjy R, Mamonjisoa JA, Rafaramino F. Prise en charge des cancers du sein en oncologie médicale au Centre Hospitalier de Soavinandriana. Rev Malg Cancerol. 2017;2(1):66-84.
BOUFATAH NA, BOUKHEDIMI N, KOUCHKAR A. Etude épidémiologique sur le cancer du sein en Algérie (Doctoral dissertation). Available at: http://dspace.univ-medea.dz/handle/123456789/70 Accessed on 12 June 2023.
Lefranc Jp, Bensaid C, Touboul E, Genestie C, Lauratet B, Janaud G, et al. Comment réduire le risque de récidive locale dans le cancer du sein après traitement conservateur?. e-mémoires de l'Académie Nationale de Chirurgie. 2004;3(4):1-7.
Chauleur C, Vulliez L, Trombert B, Khaddage A, Seffert P . Facteurs de risque de récidive des cancers du sein traités par chirurgie conservatrice : à propos de 254 cas. J Gynecol Obstet Biol Reprod. 2008;37(2):170-8.
Mannell A. An overview of risk factors for recurrent breast cancer. S Afr J Surg. 2017;55(1):29-34.
Coulombe G, Tyldesley S, Speers C, Paltiel C, Aquino-Parsons C, Bernstein , et al. Is Mastectomy Superior to Breast-Conserving Treatment for Young Women? Int J Radiat Oncol Biol Phys. 2007;67(5):1282-90. DOI: https://doi.org/10.1016/j.ijrobp.2006.11.032
Gentilini O, Botteri E, Rotmensz N, Cantillo B, Peradze N, Saihum RC, et al. When can a second conservative approach be considered for ipsilateral breast tumour recurrence? Ann Oncol. 2007;18(3):468-72. DOI: https://doi.org/10.1093/annonc/mdl424
Bakkali H, Marchal C, Lesur-Schwander A, Verhaeghe JL. Le cancer du sein chez la femme de 30 ans et moins. Cancer Radiother. 2003;7(3):153-9. DOI: https://doi.org/10.1016/S1278-3218(03)00021-0
Fortin A, Larochelle M, Laverdière J, Lavertu S, Tremblay D. Local Failure Is Responsible for the Decrease in Survival for Patients With Breast Cancer Treated With Conservative Surgery and Postoperative Radiotherapy. J Clin Oncol. 1999;17(1):101. DOI: https://doi.org/10.1200/JCO.1999.17.1.101
17. Fourquet A, Campana F, Zafrani B, Mosseri V, Vielh P, Durand JC, et al. Prognostic factors of breast recurrence in the conservative management of early breast cancer: A 25-year follow-up. Int J Radiat Oncol Biol Phys. 1989;17(4):719 25. DOI: https://doi.org/10.1016/0360-3016(89)90057-6
Borger J, Kemperman H, Hart A, Peterse H, Van Dongen J, Bartelink H. Risk factors in breast-conservation therapy. JCO. 1994;12(4):653‑60. DOI: https://doi.org/10.1200/JCO.1994.12.4.653
Hennequin C, Azria D. L’avenir de la radiothérapie du cancer du sein: de la taille unique au sur-mesure. Cancer Radiother. 2011;15(67):455-9. DOI: https://doi.org/10.1016/j.canrad.2011.05.008
Chauleur C, Vulliez L, Trombert B, Raoux D, Khaddage A, Seffert P. Facteurs de risque de récidive des cancers du sein traités par chirurgie conservatrice: à propos de 254 cas. J Gynecol Obstet Biol Reprod. 2008;37(2):170-8. DOI: https://doi.org/10.1016/j.jgyn.2007.11.027
Gweon HM, Son EJ, Youk JH, Kim J, Chung J. Value of the US BI-RADS final assessment following mastectomy: BI-RADS 4 and 5 lesions. Acta Radiol. 2012;53(3):255-60. DOI: https://doi.org/10.1258/ar.2011.110597
Kim SY, Han BK, Kim EK, Choi WJ, Choi Y, Kim HK. et al. Breast Cancer Detected at Screening US: Survival Rates and Clinical-Pathologic and Imaging Factors Associated with Recurrence. Radiology. 2017;284(2):354-64. DOI: https://doi.org/10.1148/radiol.2017162348
Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, et al. Twenty-Year Follow-up of a Randomized Study Comparing Breast-Conserving Surgery with Radical Mastectomy for Early Breast Cancer. N Engl J Med. 2002;347(16):1227-32. DOI: https://doi.org/10.1056/NEJMoa020989
Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. NEJM. 2002;347(16):1233-41. DOI: https://doi.org/10.1056/NEJMoa022152
Brewster AM, Hortobagyi GN, Broglio KR, Kau S, Santa-Maria CA, Arun B, et al. Residual Risk of Breast Cancer Recurrence 5 Years After Adjuvant Therapy. JNCI J Natl Cancer Inst. 2008;100(16):1179-83. DOI: https://doi.org/10.1093/jnci/djn233
Bertheau P, Steinberg SM, Cowan K, Merino MJ. Breast cancer in young women: clinicopathologic correlation. Semin Diagn Pathol. 1999;16(3):248-56.
Classe JM. Cancer du sein. In: Pratique en gynécologie-obstétrique. 1st ed. Elsevier Health Sciences; 2016:233.
Af BL, Jb NM. Prognostic and predictive value of the initial CA15-3 blood value in breast cancer. 2019;20.
De La Lande B. Place actuelle des dosages du CA 15.3 dans le cancer du sein. Immuno-Analyse Biol Spec. 2004;19(5):274-8. DOI: https://doi.org/10.1016/j.immbio.2004.06.008
Sparano JA, Gray RJ, Ravdin PM, Makower DF, Pritchard KI, Albain KS, et al. Clinical and Genomic Risk to Guide the Use of Adjuvant Therapy for Breast Cancer. N Engl J Med. 2019;380(25):2395-405. DOI: https://doi.org/10.1056/NEJMoa1904819
Kurtz JM. Factors influencing the risk of local recurrence in the breast. Eur J Cancer. 1992;28(23):660-6. DOI: https://doi.org/10.1016/S0959-8049(05)80121-2
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