A rare ovarian Leydig cell tumour masquerading as postmenopausal bleeding: a case report
DOI:
https://doi.org/10.18203/2320-1770.ijrcog20251604Keywords:
Sertoli-Leydig cell tumors, Postmenopausal bleeding, Endometrial hyperplasia, VirilizationAbstract
Ovarian Sertoli-Leydig cell tumors (SLCTs) are rare ones, accounting for less than 0.2% of ovarian malignancies. While typically associated with virilization, they can present atypically with postmenopausal bleeding. We report a 72-year-old postmenopausal woman with post-menopausal bleeding. The diagnosis was endometrial hyperplasia. The patient, with a history of diabetes, hypertension, and dyslipidemia, had postmenopausal bleeding lasting five days without features of virilization. Ultrasonography showed a bulky uterus with a fibroid, adenomyoma, and thickened endometrium. Endometrial sampling revealed focal hyperplasia without atypia. Despite progestin therapy, she had recurrent vaginal bleeding. Hence decision for surgical management was sought. Histopathology confirmed a 1 cm Leydig cell tumour in the right ovary, with no significant findings in the left ovary or tubes.
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References
Khalloufi C, Joudar I, Kanas A, Benhessou M, Ennachit M, Kerroumi M. Ovarian Sertoli-Leydig tumor: A tricky tumor case report. Int J Surg Case Rep. 2023;105:108043. DOI: https://doi.org/10.1016/j.ijscr.2023.108043
Chen L, Tunnell CD, De Petris G. Sertoli-Leydig cell tumor with heterologous element: a case report and a review of the literature. Int J Clin Exp Pathol. 2014;7(3):1176–81.
Tsuzuki Y, Kikuchi I, Nojima M, Yoshida K, Hashizume A, Tomita S. A Case report: ovarian sertoli-leydig cell tumor with hyperestrogenism and endometrial hyperplasia in a postmenopausal woman. J Clin Med. 2017;8:5239. DOI: https://doi.org/10.1177/1179066017695239
Moghazy D, Sharan C, Nair M, Rackauskas C, Burnette R, Diamond M, et al. Sertoli-Leydig cell tumor with unique nail findings in a post-menopausal woman: a case report and literature review. J Ovarian Res. 2014;7(1):83. DOI: https://doi.org/10.1186/PREACCEPT-6541605211285480
Xiao H, Li B, Zuo J, Feng X, Li X, Zhang R, et al. Ovarian Sertoli–Leydig cell tumor: a report of seven cases and a review of the literature. Gynecological Endocrinology. 2013 Mar;29(3):192–5. DOI: https://doi.org/10.3109/09513590.2012.738723
Bala NM, Aragüés JM, Guerra S, Brito D, Valadas C. Ovarian Leydig cell tumor: cause of virilization in a postmenopausal woman. The American J Case Rep. 2021;22:933126-1. DOI: https://doi.org/10.12659/AJCR.933126
Verdorfer I, Horst D, Höllrigl A, Rogatsch H, Mikuz G. Sertoli–Leydig cell tumours of the ovary and testis: a CGH and FISH study. Virchows Arch. 2007;450(3):267–71. DOI: https://doi.org/10.1007/s00428-006-0344-9
Cabrera-Cantú F, Urrutia-Osorio M, Valdez-Arellano F, Rivadeneyra-Espinoza L, Papaqui A, Soto-Vega E. Sertoli–Leydig cell tumor in a 12-year-old girl: a review article and case report. Arch Gynecol Obstet. 2014;290(4):791–6. DOI: https://doi.org/10.1007/s00404-014-3293-6
Prassopoulos V, Laspas F, Vlachou F, Efthimiadou R, Gogou L, Andreou J. Leydig cell tumour of the ovary localised with Positron Emission Tomography/Computed Tomography. Gynecol Endocrinol. 2011;27(10):837–9. DOI: https://doi.org/10.3109/09513590.2010.521263
Gui T, Cao D, Shen K, Yang J, Zhang Y, Yu Q, et al. A clinicopathological analysis of 40 cases of ovarian Sertoli–Leydig cell tumors. Gynecologic Oncol. 2012;127(2):384–9. DOI: https://doi.org/10.1016/j.ygyno.2012.07.114