Identification of risk factors of premature rupture of membrane at a tertiary care centre: a case-control study

Mahima Sengar; Ruchi Kalra

doi:10.18203/2320-1770.ijrcog20251579

Authors

Mahima Sengar Department of Obstetrics and Gynecology, People’s College of Medical Sciences and Research Centre, Bhopal, Madhya Pradesh, India
Ruchi Kalra Department of Obstetrics and Gynecology, People’s College of Medical Sciences and Research Centre, Bhopal, Madhya Pradesh, India

DOI:

https://doi.org/10.18203/2320-1770.ijrcog20251579

Keywords:

Obstetric complications, Preterm birth, Premature rupture of membranes

Abstract

Background: Premature rupture of membranes (PROM) is a critical issue in obstetrics, occurring in 3-4% of pregnancies and accounting for 40-50% of preterm births. This study aims to identify risk factors associated with premature rupture of membranes in women who deliver at tertiary care centre.

Methods: This research is a case-control study conducted with 240 women at the Department of Obstetrics and Gynaecology, People's College of Medical Sciences and Research Institute, Bhopal. The study comprised 80 cases and 160 controls in a 1:2 ratio.

Results: There were no significant demographic differences between cases and controls. However, significant differences were found in past obstetric and gynecological histories. PROM was strongly associated with previous PROM (Adjusted OR: 4.62, 95% CI: 2.06-10.52), previous lower segment cesarean section (LSCS) (Adjusted OR: 2.08, 95% CI: 1.14-6.74), abnormal vaginal discharge (AOR: 2.35, 95% CI: 2.53-22.46) and urinary tract infections (UTI) (AOR: 3.40, 95% CI: 6.56-13.04).

Conclusions: Key risk factors for premature rupture of membranes include previous PROM, LSCS, abnormal vaginal discharge and UTIs. Addressing these factors is crucial for preventing PROM and enhancing maternal and fetal health outcomes.

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References

Menon R, Richardson LS, Lappas M. Fetal membrane architecture, aging and inflammation in pregnancy and parturition. Placenta. 2019;79:40-5. DOI: https://doi.org/10.1016/j.placenta.2018.11.003

Danciu BM, Oţelea MR, Marincaş MA, Niţescu M, Simionescu AA. Is Spontaneous Preterm Prelabor of Membrane Rupture Irreversible. A Review of Potentially Curative Approaches. Biomedicines. 2023;11(7):1900. DOI: https://doi.org/10.3390/biomedicines11071900

Shailja D, Hong PL. Premature Rupture of Membranes. Treasure Island (FL): StatPearls Publishing. 2024.

Garg A, Jaiswal A. Evaluation and management of premature rupture of membranes: a review article. Cureus. 2023;15(3):36615. DOI: https://doi.org/10.7759/cureus.36615

Dange VI, Patil AS. Study of patient with premature rupture of membrane. Medpul Int J Gynaecol. 2019;11(3):64-8. DOI: https://doi.org/10.26611/10121136

Assefa NE, Berhe H, Girma F, Berhe K, Berhe YZ, Gebreheat G, et al. Risk factors of premature rupture of membranes in public hospitals at Mekele city, Tigray, a case control study. BMC Preg Childbirth. 2018;18:1-7. DOI: https://doi.org/10.1186/s12884-018-2016-6

Zhou Q, Zhang W, Xu H, Liang H, Ruan Y, Zhou S, et al. Risk factors for preterm premature rupture of membranes in Chinese women from urban cities. International J Gynecol Obstetrics. 2014;1;127(3):254-9. DOI: https://doi.org/10.1016/j.ijgo.2014.06.020

Enjamo M, Deribew A, Semagn S, Mareg M. Determinants of Premature Rupture of Membrane (PROM) Among Pregnant Women in Southern Ethiopia: A Case-Control Study. Int J Womens Health. 2022;31;14:455-466. DOI: https://doi.org/10.2147/IJWH.S352348

Harger JH, Hsing AW, Tuomala RE, Gibbs RS, Mead PB, Eschenbach DA, et al. Risk factors for preterm premature rupture of fetal membranes: a multicenter case-control study. American journal of obstetrics and gynecology. 1990;163(1):130-7. DOI: https://doi.org/10.1016/S0002-9378(11)90686-3

Kaye D. Risk factors for preterm premature rupture of membranes at Mulago Hospital, Kampala. East Afr Med J. 2001;78(2):65-9. DOI: https://doi.org/10.4314/eamj.v78i2.9090

Noor S, Nazar AF, Bashir R, Sultana R. Prevalance of PPROM and its outcome. J Ayub Med Coll Abbottabad. 2007;19(4):14-7.

Wondosen M. Determinants of term premature rupture of membrane: case-control study in Saint Paul’s Millennium Medical College Hospital, Addis Ababa, Ethiopia. Addis Ababa, Ethiopia. 2023.

Allen RS. The epidemiology of premature rupture of the foetal membranes. Clin Obstet Gynaec. 1991:34:685-93. DOI: https://doi.org/10.1097/00003081-199112000-00004

Choudhary M, Rathore SB, Chowdhary J, Garg S. Pre and Post conception Risk factors in PROM. Int J Res Med Sci 2015;3:2594-8. DOI: https://doi.org/10.18203/2320-6012.ijrms20150797

Gomez R, Romero R, Nien JK, Chaiworapongsa T, Medina L, Kim YM, et al. A short cervix in women with preterm labor and intact membranes: a risk factor for microbial invasion of the amniotic cavity. American J Obst Gynecol. 2005;192(3):678-89. DOI: https://doi.org/10.1016/j.ajog.2004.10.624

Holst RM, Jacobsson B, Hagberg H, Wennerholm UB. Cervical length in women in preterm labor with intact membranes: relationship to intra‐amniotic inflammation/microbial invasion, cervical inflammation and preterm delivery. Ultrasound in Obstetrics and Gynecology. The Official J International Soc Ultrasound Obstetrics Gynecol. 2006;28(6):768-74. DOI: https://doi.org/10.1002/uog.3837